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The map label for this gene is hisG [H]

Identifier: 21227605

GI number: 21227605

Start: 1792599

End: 1793468

Strand: Direct

Name: hisG [H]

Synonym: MM_1503

Alternate gene names: 21227605

Gene position: 1792599-1793468 (Clockwise)

Preceding gene: 21227597

Following gene: 21227606

Centisome position: 43.76

GC content: 45.17

Gene sequence:

>870_bases
ATGATTCGCATTGCAATACCCAATAAAGGGCGCCTTTATGAACCCACAATCTCTATTTTTAAAGATGCAGGGCTCCCTAT
CAGCGGAGGAGCCGAAAGCAGAAAACTTTTTGCAAAAACTACAGACCCGGATATCCATATCCTCTTTGCCAGGGCTGCTG
ACATTCCTGAATATGTACAGGACGGAGCTGCAGACGTTGGTATTACGGGCATGGACCTGATTACCGAAAGAGGGGCAAAT
GTTGAGGCTCTTCTGGACCTTAAATTCGGGAGGGCGAATCTTGTGCTGGCTGTCCCGGAAGACTCGGACTTTGAAAAAGC
ACAGGACCTTGAAGGTAAAAAAGTGGCAACCGAGTTTCCTGAAATTACGAGGCGATACTTTGAAAAACTCGGAGTTAACG
TAAATGTTATAAAAGTAAGCGGCGCATGTGAAATGACCCCTCACGTGGGGATTGCAGATGCCATTGTTGATATCTCAAGT
TCGGGGACAACTTTGCTTATCAACCACCTGAAGGCTATTGATATGGCTTTCTCTTCCACTGTCTATCTTATCGCTAACAA
AGAGAGCCTCAGGACAAAAGAGAAAATCCTTGACATAAAAACAGCATTCGAAAGCGTGCTCAATGCAAAGAAAAAACGTT
ATCTAATGATGAATGTACCTGAATCTTCCCTTAAAGCCGTAAAAGAGGTTCTTCCGGGAATGTCAGGCCCGACAGTGATG
AAAGTTGAATCCAGCAAGTTTTCTGAAGAATCGATACTTGCCGTTCATGCTGTTGTGGACGCGGACCTGATCTTTACTAT
CGTAAACAGGCTGAAGAAAGTTGGCGCAAGAGACGTCCTTGTGGTCCCCATAGAAAGGATCATGCCCTGA

Upstream 100 bases:

>100_bases
TGAAGTCTATATTATACAAGGGTGTTCTGGATAAACGTTTTATACGGATGAGCTTACCGGGAAATTTCCCGTCAGATCAC
ATATTTAGAGGACAGCGCAG

Downstream 100 bases:

>100_bases
ATGAAAAATCTGAATAGCATACATAAAATACATAAATCACTGAAGTGAAAAAATATTCCTGTAAAATATGGAGATGTAGC
TTTTTATGGTCTTTGAAGTA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MIRIAIPNKGRLYEPTISIFKDAGLPISGGAESRKLFAKTTDPDIHILFARAADIPEYVQDGAADVGITGMDLITERGAN
VEALLDLKFGRANLVLAVPEDSDFEKAQDLEGKKVATEFPEITRRYFEKLGVNVNVIKVSGACEMTPHVGIADAIVDISS
SGTTLLINHLKAIDMAFSSTVYLIANKESLRTKEKILDIKTAFESVLNAKKKRYLMMNVPESSLKAVKEVLPGMSGPTVM
KVESSKFSEESILAVHAVVDADLIFTIVNRLKKVGARDVLVVPIERIMP

Sequences:

>Translated_289_residues
MIRIAIPNKGRLYEPTISIFKDAGLPISGGAESRKLFAKTTDPDIHILFARAADIPEYVQDGAADVGITGMDLITERGAN
VEALLDLKFGRANLVLAVPEDSDFEKAQDLEGKKVATEFPEITRRYFEKLGVNVNVIKVSGACEMTPHVGIADAIVDISS
SGTTLLINHLKAIDMAFSSTVYLIANKESLRTKEKILDIKTAFESVLNAKKKRYLMMNVPESSLKAVKEVLPGMSGPTVM
KVESSKFSEESILAVHAVVDADLIFTIVNRLKKVGARDVLVVPIERIMP
>Mature_289_residues
MIRIAIPNKGRLYEPTISIFKDAGLPISGGAESRKLFAKTTDPDIHILFARAADIPEYVQDGAADVGITGMDLITERGAN
VEALLDLKFGRANLVLAVPEDSDFEKAQDLEGKKVATEFPEITRRYFEKLGVNVNVIKVSGACEMTPHVGIADAIVDISS
SGTTLLINHLKAIDMAFSSTVYLIANKESLRTKEKILDIKTAFESVLNAKKKRYLMMNVPESSLKAVKEVLPGMSGPTVM
KVESSKFSEESILAVHAVVDADLIFTIVNRLKKVGARDVLVVPIERIMP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=31.5436241610738, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320896, Length=286, Percent_Identity=34.2657342657343, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 31527; Mature: 31527

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIAIPNKGRLYEPTISIFKDAGLPISGGAESRKLFAKTTDPDIHILFARAADIPEYVQ
CEEEEECCCCCEECHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHH
DGAADVGITGMDLITERGANVEALLDLKFGRANLVLAVPEDSDFEKAQDLEGKKVATEFP
CCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCEEEEECCCCCCCHHHHCCCCCHHHHHHH
EITRRYFEKLGVNVNVIKVSGACEMTPHVGIADAIVDISSSGTTLLINHLKAIDMAFSST
HHHHHHHHHHCCCEEEEEECCCEECCCCCCHHHHHEEECCCCCEEEHHHHHHHHHHHCCE
VYLIANKESLRTKEKILDIKTAFESVLNAKKKRYLMMNVPESSLKAVKEVLPGMSGPTVM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHCCCCCCEEE
KVESSKFSEESILAVHAVVDADLIFTIVNRLKKVGARDVLVVPIERIMP
EEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MIRIAIPNKGRLYEPTISIFKDAGLPISGGAESRKLFAKTTDPDIHILFARAADIPEYVQ
CEEEEECCCCCEECHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHH
DGAADVGITGMDLITERGANVEALLDLKFGRANLVLAVPEDSDFEKAQDLEGKKVATEFP
CCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCEEEEECCCCCCCHHHHCCCCCHHHHHHH
EITRRYFEKLGVNVNVIKVSGACEMTPHVGIADAIVDISSSGTTLLINHLKAIDMAFSST
HHHHHHHHHHCCCEEEEEECCCEECCCCCCHHHHHEEECCCCCEEEHHHHHHHHHHHCCE
VYLIANKESLRTKEKILDIKTAFESVLNAKKKRYLMMNVPESSLKAVKEVLPGMSGPTVM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHCCCCCCEEE
KVESSKFSEESILAVHAVVDADLIFTIVNRLKKVGARDVLVVPIERIMP
EEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA