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The map label for this gene is eif2b [H]

Identifier: 21227577

GI number: 21227577

Start: 1758505

End: 1759113

Strand: Reverse

Name: eif2b [H]

Synonym: MM_1475

Alternate gene names: 21227577

Gene position: 1759113-1758505 (Counterclockwise)

Preceding gene: 21227578

Following gene: 21227576

Centisome position: 42.94

GC content: 48.44

Gene sequence:

>609_bases
ATGTATGATTACGAAGAGCTTTTGAACCGTGCAATGTCAAAGATGCCGGACACAGAGACTACTGACGCTCGATTCGTAAT
CCCTGAACCCAAACTCTTTTCCGAAGGCAAAACCACAATTCTGGATAACTTCGGAAATATTGCAGACACCCTTAACCGGG
ACCCTGACCACCTGATGAAATACCTCACCAGGGAACTGGGGACTGCAGGGAAGATAGAAGGCACACGTGCAGTCTTCCAG
GGCAGGTTTACAAGAGCTCAGCTTTCAGACAATATTCAGGCATATGTTGACGAATACGTTATGTGTTCGGAATGCGGACG
CCCGGATACCCAGCTTGTCAGGGTAGACAGGGTTCTTGTCCTGAAATGTTCTGCTTGCGGAGCACATAGACCTGTCAAAA
AGAGAAAGGTAAGCAACGTTGTTGTCAGGGAAGCCATCGAAGAGGGCGGAACCTATGAACTCCGGATAGATGCCGTTGGG
TCCAAAGGTGACGGGATAGCAAAAATAGACAAGTATACAGTCTTTGTGCCCGGAGCCACAAAAGGCGACGTGGTAAAAGT
AAAGATAAAGAAGATCAGCGGAAACCTCGCCTTCTCGGAAAGGGCTTGA

Upstream 100 bases:

>100_bases
GACAGAAGCTGCCTACACCCGTCAGAATCGTTATCGATGAAGGCGCAGAACTCGTACAGTAAGCGGAAAGAAGCCGTAAA
ATTACAAGGGAGTCTAAAGA

Downstream 100 bases:

>100_bases
GGTCCAGGCTTTTTATTTTAAAGAGGCAGTCCAGGCCGACTACTAATCAGTTATCGAGCTTGGACAGCTTAAGTCCTCAT
TTTCGAAATTGATAAACTTA

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MYDYEELLNRAMSKMPDTETTDARFVIPEPKLFSEGKTTILDNFGNIADTLNRDPDHLMKYLTRELGTAGKIEGTRAVFQ
GRFTRAQLSDNIQAYVDEYVMCSECGRPDTQLVRVDRVLVLKCSACGAHRPVKKRKVSNVVVREAIEEGGTYELRIDAVG
SKGDGIAKIDKYTVFVPGATKGDVVKVKIKKISGNLAFSERA

Sequences:

>Translated_202_residues
MYDYEELLNRAMSKMPDTETTDARFVIPEPKLFSEGKTTILDNFGNIADTLNRDPDHLMKYLTRELGTAGKIEGTRAVFQ
GRFTRAQLSDNIQAYVDEYVMCSECGRPDTQLVRVDRVLVLKCSACGAHRPVKKRKVSNVVVREAIEEGGTYELRIDAVG
SKGDGIAKIDKYTVFVPGATKGDVVKVKIKKISGNLAFSERA
>Mature_202_residues
MYDYEELLNRAMSKMPDTETTDARFVIPEPKLFSEGKTTILDNFGNIADTLNRDPDHLMKYLTRELGTAGKIEGTRAVFQ
GRFTRAQLSDNIQAYVDEYVMCSECGRPDTQLVRVDRVLVLKCSACGAHRPVKKRKVSNVVVREAIEEGGTYELRIDAVG
SKGDGIAKIDKYTVFVPGATKGDVVKVKIKKISGNLAFSERA

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=134, Percent_Identity=39.5522388059701, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508049, Length=137, Percent_Identity=34.3065693430657, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325018, Length=143, Percent_Identity=35.6643356643357, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325298, Length=111, Percent_Identity=31.5315315315315, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647377, Length=134, Percent_Identity=37.3134328358209, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR004458
- InterPro:   IPR002792
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B; PF01938 TRAM [H]

EC number: NA

Molecular weight: Translated: 22471; Mature: 22471

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDYEELLNRAMSKMPDTETTDARFVIPEPKLFSEGKTTILDNFGNIADTLNRDPDHLMK
CCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHCCCCHHHHHCCCHHHHHCCCCHHHHHH
YLTRELGTAGKIEGTRAVFQGRFTRAQLSDNIQAYVDEYVMCSECGRPDTQLVRVDRVLV
HHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECEEEE
LKCSACGAHRPVKKRKVSNVVVREAIEEGGTYELRIDAVGSKGDGIAKIDKYTVFVPGAT
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEECCCC
KGDVVKVKIKKISGNLAFSERA
CCCEEEEEEEEECCCEEECCCC
>Mature Secondary Structure
MYDYEELLNRAMSKMPDTETTDARFVIPEPKLFSEGKTTILDNFGNIADTLNRDPDHLMK
CCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHCCCCHHHHHCCCHHHHHCCCCHHHHHH
YLTRELGTAGKIEGTRAVFQGRFTRAQLSDNIQAYVDEYVMCSECGRPDTQLVRVDRVLV
HHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECEEEE
LKCSACGAHRPVKKRKVSNVVVREAIEEGGTYELRIDAVGSKGDGIAKIDKYTVFVPGAT
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEECCCC
KGDVVKVKIKKISGNLAFSERA
CCCEEEEEEEEECCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]