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The map label for this gene is prf11 [H]

Identifier: 21227449

GI number: 21227449

Start: 1613824

End: 1615071

Strand: Direct

Name: prf11 [H]

Synonym: MM_1347

Alternate gene names: 21227449

Gene position: 1613824-1615071 (Clockwise)

Preceding gene: 21227448

Following gene: 21227450

Centisome position: 39.4

GC content: 46.31

Gene sequence:

>1248_bases
ATGACTGAACAATCCGCACATGAAAAATACGAATTTAAAAAGAAGCTTGAGGGTCTCAGGGACAAGAAAGGAAGAAGCAC
TGAGCTTATATCTCTCTATATCCCTCCTGATAAGCAAATTTTCGATGTCACAAACCAGTTAAAAGACGAGCATGGGCAGG
CTGCTAATATCAAGTCCAAGCTTACGAGGACAAATGTTCAGGGGGCAATCGAGTCTCTGCTTTCAAGGCTCAGATACTTG
GACAAAGTGCCTGAGAACGGGATAGTATACTTTACGGGTGCTGTTGATATAGGAGCTAATAAGACGAGCATGGAAAGCGA
GGTAATCGTTCCTCCTGACCCCATCACTGTCTATAAGTATCACTGTGATTCATCTTTCTATCTTGAGCCTCTTGAGGACA
TGCTTAAAGATAAGAACACTTACGGACTTCTGGTTCTTGACCGCAGGGAAGCAACCATAGGTCTTCTTGTGGGAAAAAGA
ATCCAGCCTTTCCGCAACCTGACATCAACAGTTCCGGGAAAGCAGAGGAAAGGAGGTCAGAGTGCCCACCGTTTCCAGCA
GCTCAGGCTTATCGCAATCCATGACTTTTACAAGAGGATAGGAGATGCTGCAAGTGAAGTCTTCATGGCTGTTGACCACA
AAGACCTCAAGGGTGTGCTTATTGGAGGTCCCTCTCCGACAAAAGAAGAGTTTCATGCAGGGGAGTTTTTGCACCATGAA
CTCATGAAGAAAATCCTTGGACTCTTTGATACGGCATACACCGATGAATCCGGGCTTTCCGAGCTTGTTAATGCTGCAGG
TGAAAAGCTTCAGGACCTTGAACTCATGGGCCAGAAAAATGCTGTCAGAGACTTTTTCAAGGAACTGATCGCCGATTCGG
GTAAGGTAGCCTACGGTGAATCTCAGGTAAGGGCAAACCTTGAGATTAATTCTGTGGACGTGCTCCTGCTTTCCGAAGAT
CTGCGTGCAGAAAGAGTAACTACAAAATGCAGTGTCTGCGGATATGAAAACAAGTGGACAAGGCGCTGGAAACCCGGAGA
ACCCGCACCTGCAGCAGGGAACTGTCCCAAGTGTGGCTCTTCTCTTGAGGTTACGGATGTTACTGATATTGTTGACGAAT
TCTCTGAGCTTGCCGACAAAAGTAATGCAAAAGTGGTCTTCGTATCCACAGACTTTGATGAAGGTTCTCAGCTCATGAAC
GCCTTTGGAGGCATAGCTGCAATCCTGAGATACAATACCGGAGTCTGA

Upstream 100 bases:

>100_bases
TAAATTAATCTGGCTAACGAAACAATTTAAAGTTTCAATTCGCTAACAAAGTCACAATAATCACGAATCATACTTCTTTA
TTCATCGGGGAATTCTTAAA

Downstream 100 bases:

>100_bases
TCTCATTCAGGGGCAAAGTCCCCTCCTCCTATCCGGTAATTTTTTACCCAATACTTTTTTAATTCAATTGTCCTTTAGAT
CAGTGGATCAGGAGTTGTAA

Product: peptide chain release factor 1

Products: NA

Alternate protein names: Translation termination factor aRF1 1 [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSKLTRTNVQGAIESLLSRLRYL
DKVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKYHCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKR
IQPFRNLTSTVPGKQRKGGQSAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHE
LMKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGESQVRANLEINSVDVLLLSED
LRAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGSSLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMN
AFGGIAAILRYNTGV

Sequences:

>Translated_415_residues
MTEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSKLTRTNVQGAIESLLSRLRYL
DKVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKYHCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKR
IQPFRNLTSTVPGKQRKGGQSAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHE
LMKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGESQVRANLEINSVDVLLLSED
LRAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGSSLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMN
AFGGIAAILRYNTGV
>Mature_414_residues
TEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSKLTRTNVQGAIESLLSRLRYLD
KVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKYHCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKRI
QPFRNLTSTVPGKQRKGGQSAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHEL
MKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGESQVRANLEINSVDVLLLSEDL
RAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGSSLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMNA
FGGIAAILRYNTGV

Specific function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA [H]

COG id: COG1503

COG function: function code J; Peptide chain release factor 1 (eRF1)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic release factor 1 family [H]

Homologues:

Organism=Homo sapiens, GI4759034, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI72000368, Length=404, Percent_Identity=28.2178217821782, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319619, Length=404, Percent_Identity=27.970297029703, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574632, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21356433, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24667392, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24667388, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24667380, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24667384, Length=405, Percent_Identity=30.8641975308642, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005140
- InterPro:   IPR005141
- InterPro:   IPR005142
- InterPro:   IPR020918
- InterPro:   IPR004403 [H]

Pfam domain/function: PF03463 eRF1_1; PF03464 eRF1_2; PF03465 eRF1_3 [H]

EC number: NA

Molecular weight: Translated: 46190; Mature: 46059

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSK
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHH
LTRTNVQGAIESLLSRLRYLDKVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKY
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCEEEEEE
HCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKRIQPFRNLTSTVPGKQRKGGQ
ECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEHHCCCHHHHHHHHHCCCCCCCCCCH
SAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
LMKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECC
SQVRANLEINSVDVLLLSEDLRAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGS
CCEEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMNAFGGIAAILRYNTGV
CCEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSK
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHH
LTRTNVQGAIESLLSRLRYLDKVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKY
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCEEEEEE
HCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKRIQPFRNLTSTVPGKQRKGGQ
ECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEHHCCCHHHHHHHHHCCCCCCCCCCH
SAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
LMKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECC
SQVRANLEINSVDVLLLSEDLRAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGS
CCEEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMNAFGGIAAILRYNTGV
CCEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]