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The map label for this gene is 21227448

Identifier: 21227448

GI number: 21227448

Start: 1611885

End: 1612982

Strand: Direct

Name: 21227448

Synonym: MM_1346

Alternate gene names: NA

Gene position: 1611885-1612982 (Clockwise)

Preceding gene: 21227447

Following gene: 21227449

Centisome position: 39.35

GC content: 46.17

Gene sequence:

>1098_bases
GTGCTCTACCTGCAGTTCTCTAAAATTATTTTCCGATCCTTATATATACCACAAAGAATTAATATCCGAAAAATGCCGCT
TGAAGAAAAAAAGAAAGAACAGGAAAATTTCGGGGAAAACCTTCCTGAAGTCCAGGAAGAAAACACAGGTGAAGAGCAGA
CTTCTCTTCCCTTTGATATCCCTGATTTTGCTACCCTTCTTAAAAAGCAGGGCTATGCCCTGGCAGGCCGCCACTCGGCT
GTAAAGACCTGTCTCTGGCTCCGGAAAGCCATGAACGACGAAGGCTTCTGCTACAAATCGAAATTTTACGGAGTTCAGTC
CCACCGATGCCTTCAGATGACTCCAACTCTTATGTGCAACCAGCGCTGTCTTTTCTGCTGGCGTCCTACTGAGGTTCCTG
TGCCCGCGCCCGGAGAATGGGACTTTCCTGAAAAGATAGTTGAGGAAAGCATTGCCTGCCAGCGCAAATTGATTACGGGT
TTCGGTGGCTCTCCAAATGCACTCCGGGAACGCTGGCTTGAGGGCAATCAGCCCAATAATGTCGCAATCTCACTGTCCGG
AGAGCCAACATTTTACCCTTACCTTCCGGAACTCATTGAGGAATACGAAAAAAGAGGATTTACTACCTTTCTGGTAACAA
ATGGAACTGTCCCCTCGATGCTCGCAAAAGTTAATCCTTCCCAATTATACATGAGCCTTGACGCCCCTGACCTTGAGACC
TATCTCAGGATCTGCCAGCCAAAATCTCCTGCACTCTGGGACAGGATAAATGAGTCCCTGGACATCATGAAGGATAAATC
CTCGCGGACAGTCATCAGAACCACTCTTGTTAAGGGTGAAAACATATTCAATCCGGAAGGTTACGCCGAAATGATTAAAA
AAGCCTCACCGGATTTTGTTGAAATTAAAGCCTATATGCACCTTGGTTTCTCACGGCTTCGCCTTGAACGCTCTGCCATG
CCGTCTCATGAAGAAGTGCTTGAATTTTCAAAAGAACTCGCAAAGCACCTGGGATATGAAATTGCAGACGAATCCGAAAT
CAGCCGGGTAGTTTTGCTTTCAAAGGACGGAAGAAAATCTCCTGTAAAAAAGAAGTAG

Upstream 100 bases:

>100_bases
GCAGATTTTGATGTAAAGATCCTGGCATTCGATTAAATTAAGTTGACCGAATCTTTTTGATCAGGACAGGACTGAGAATT
CTAATTGCTCTGCCATCTGT

Downstream 100 bases:

>100_bases
TAAAAAGAAGTAGTAAAAAGAAGTAGTAAAAAGAAGCAGTAAAAAGAAGCAGTAAAAAGAAGCAGTAAAAAGAAGTAGTA
AAAAGAAGTAGTAAAAAGAA

Product: tRNA-modifying enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSA
VKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITG
FGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAM
PSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK

Sequences:

>Translated_365_residues
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSA
VKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITG
FGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAM
PSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>Mature_365_residues
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSA
VKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITG
FGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAM
PSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK

Specific function: Unknown

COG id: COG0731

COG function: function code C; Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0026 family [H]

Homologues:

Organism=Homo sapiens, GI50726981, Length=299, Percent_Identity=38.1270903010033, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI224282123, Length=254, Percent_Identity=35.4330708661417, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI224282125, Length=254, Percent_Identity=35.4330708661417, Blast_Score=159, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325049, Length=301, Percent_Identity=34.21926910299, Blast_Score=192, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197
- InterPro:   IPR013917 [H]

Pfam domain/function: PF04055 Radical_SAM; PF08608 Wyosine_form [H]

EC number: NA

Molecular weight: Translated: 41969; Mature: 41969

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDI
CEEEEHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCCHHHCCCCCHHCCCCCCC
PDFATLLKKQGYALAGRHSAVKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCN
HHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCEEECCHHHHCC
QRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITGFGGSPNALRERWLEGNQPNN
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
VAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
EEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCHHHEEEECCCCCHHH
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFV
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCE
EIKAYMHLGFSRLRLERSAMPSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKS
EEHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCC
PVKKK
CCCCC
>Mature Secondary Structure
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDI
CEEEEHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCCHHHCCCCCHHCCCCCCC
PDFATLLKKQGYALAGRHSAVKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCN
HHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCEEECCHHHHCC
QRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITGFGGSPNALRERWLEGNQPNN
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
VAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
EEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCHHHEEEECCCCCHHH
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFV
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCE
EIKAYMHLGFSRLRLERSAMPSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKS
EEHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCC
PVKKK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]