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The map label for this gene is argS [H]

Identifier: 21227450

GI number: 21227450

Start: 1615333

End: 1617042

Strand: Direct

Name: argS [H]

Synonym: MM_1348

Alternate gene names: 21227450

Gene position: 1615333-1617042 (Clockwise)

Preceding gene: 21227449

Following gene: 21227451

Centisome position: 39.43

GC content: 48.19

Gene sequence:

>1710_bases
TTGTTCCTGGAACTCAAAGCTCAGGCTACATCAATCTTAAAAGAAGCTATTCGAAAAGCAGGGTTTGAGGTTGAGGATTC
CGAACTTCAATTCGAAACCTCTCCTCATGCTGACCTTGCAAGCAGAGCCGCATTCAGGCTTGCGGGCATTCACAGGCAAA
ACCCAAAAGATCTGGCGTCACGCATCGTTTCTGCAGTTGAAATTCCTGAAGGCTCATTTATAGGAAAAGTGAGTGCCGCA
GGTCCTTATATTAACTTCTTTGCAGGAAAGCACTACCTTAATGGAACGGTGAATGCTGTCCTTAAAGAGAAAGAGAAGTT
TGGCTGCGGGGCTCCAAAGGACAGAATTCTCCTTGAACACACCTCGGCAAACCCAAACGGTCCCCTTCATGTAGGGCATA
TCCGTAACTCAATTATAGGGGATACTCTTGCCCGCATCCTCAGACGCGCAGGATACGACGTGGAGGTCCAGTATTATGTT
AATGATATGGGCAGACAGATTGCTGTAGTATCATGGGCGTGTGAACGCTTTGAGCTTGACCTCTCCAGAAAGTCCGATTC
CGCAATTGCTGACGTATATATTAAAGCCAATGTTGAGCTGGACAAAAACCCTGGGTATATAAAGGAAATTGATGCCCTCA
TGGAAAAGGTGGAAGCCGGAGATGTCAGGACTATCGAGCATTTTGATAAGGCAGTTTCTCTGGCTGTTGCAGGTATCAAG
GAGACTCTGCTCCGTTTAAATGTGGCTCACGATAAGTTCGTAAGTGAGTCCACTTTCCTTAAGTCCGGTGCAGTCCATGA
TATTGTTGAACGCATCAAGGCTACAGGCAGGACAAAAACGGACAAAGGAGCTCTTGTTGTTGACCTTTCGGATTACGGGT
TTGAAAAGACTCTTGTTATCCAGCGTTCAAACGGCACTTCTCTCTACACAACCCGCGACCTTGCTTACCACGAATGGAAA
GCCGGGCAGGCAGACCGCATAATTGATGTTTTCGGAGCCGACCACAAGCTTATTTCCGGCCAGCTCAGGGCTACTCTGAA
TGCGATCGGAGTCAAAGAGCCTGAGGTTGTAATCTTTGAGTTTGTCTCTCTGCCTGAAGGCTCCATGAGCACCCGCCGCG
GGCAGTTTATAAGCGCGGACGATCTTTTTGATAGGGTCACTGGAGCTGCTTTTGAACAGGTCGAAACCCGCCGCCCTGAA
ACATCATATGAATTCAAAAAGCAGGTTGCAGAAGCAGTAGGACTTGGTGCGGTCCGCTACGATATAGTCAGGGTTTCTCC
CGAAAAATCCACAGTCTTCAACTGGAAAGAAGCTCTTGATTTTGAGAAGCAGGGAGCTCCTTACATCCAGTATTCCCATG
CGCGTGCCTGCAGCATCCTTGAGAAAGCAAAAGAGGAAGCAGCCTGGAATCCTGATAAAGAGATTGACCCCTCTCTCCTT
GTCGAAGACAGCGAGATCGATCTTATTAAGAAGATGGCGATGTTTGACAGCGTCATCGACCTTGGAGCTCGTGAACTCAA
GCCCCACGTTCTAGCTATTTATGCCCGCGAACTTGCCGATGCCTTCAACCAGTTCTACCGTTTCGTTCCGGTTATTGCAG
CCGAGGATGAAAATGTCAGGGCTGCAAGGCTGGCTCTTGTGGACTGTGCCAGGGTCGTCCTTGCAAATTCTCTTGATACT
CTTGGAATTATTGCCCCTGAATCAATGTAA

Upstream 100 bases:

>100_bases
GATAATAGATCAGATCACAATTTGACAGATTAAATCTATCATACAAGGATTTATTAAGTAATTTCAGTTTTTTACAGGTA
ATTTATACAGGTGATTAATC

Downstream 100 bases:

>100_bases
AAAAGCAAAATAAACGAAAGGAATCGAAAGAGAGAATAGCAGATAAAAGAAAAAAAATCTAAAAGAAAAAATCTAAAAGA
AAAAATCTAAAAGAAAAATC

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MFLELKAQATSILKEAIRKAGFEVEDSELQFETSPHADLASRAAFRLAGIHRQNPKDLASRIVSAVEIPEGSFIGKVSAA
GPYINFFAGKHYLNGTVNAVLKEKEKFGCGAPKDRILLEHTSANPNGPLHVGHIRNSIIGDTLARILRRAGYDVEVQYYV
NDMGRQIAVVSWACERFELDLSRKSDSAIADVYIKANVELDKNPGYIKEIDALMEKVEAGDVRTIEHFDKAVSLAVAGIK
ETLLRLNVAHDKFVSESTFLKSGAVHDIVERIKATGRTKTDKGALVVDLSDYGFEKTLVIQRSNGTSLYTTRDLAYHEWK
AGQADRIIDVFGADHKLISGQLRATLNAIGVKEPEVVIFEFVSLPEGSMSTRRGQFISADDLFDRVTGAAFEQVETRRPE
TSYEFKKQVAEAVGLGAVRYDIVRVSPEKSTVFNWKEALDFEKQGAPYIQYSHARACSILEKAKEEAAWNPDKEIDPSLL
VEDSEIDLIKKMAMFDSVIDLGARELKPHVLAIYARELADAFNQFYRFVPVIAAEDENVRAARLALVDCARVVLANSLDT
LGIIAPESM

Sequences:

>Translated_569_residues
MFLELKAQATSILKEAIRKAGFEVEDSELQFETSPHADLASRAAFRLAGIHRQNPKDLASRIVSAVEIPEGSFIGKVSAA
GPYINFFAGKHYLNGTVNAVLKEKEKFGCGAPKDRILLEHTSANPNGPLHVGHIRNSIIGDTLARILRRAGYDVEVQYYV
NDMGRQIAVVSWACERFELDLSRKSDSAIADVYIKANVELDKNPGYIKEIDALMEKVEAGDVRTIEHFDKAVSLAVAGIK
ETLLRLNVAHDKFVSESTFLKSGAVHDIVERIKATGRTKTDKGALVVDLSDYGFEKTLVIQRSNGTSLYTTRDLAYHEWK
AGQADRIIDVFGADHKLISGQLRATLNAIGVKEPEVVIFEFVSLPEGSMSTRRGQFISADDLFDRVTGAAFEQVETRRPE
TSYEFKKQVAEAVGLGAVRYDIVRVSPEKSTVFNWKEALDFEKQGAPYIQYSHARACSILEKAKEEAAWNPDKEIDPSLL
VEDSEIDLIKKMAMFDSVIDLGARELKPHVLAIYARELADAFNQFYRFVPVIAAEDENVRAARLALVDCARVVLANSLDT
LGIIAPESM
>Mature_569_residues
MFLELKAQATSILKEAIRKAGFEVEDSELQFETSPHADLASRAAFRLAGIHRQNPKDLASRIVSAVEIPEGSFIGKVSAA
GPYINFFAGKHYLNGTVNAVLKEKEKFGCGAPKDRILLEHTSANPNGPLHVGHIRNSIIGDTLARILRRAGYDVEVQYYV
NDMGRQIAVVSWACERFELDLSRKSDSAIADVYIKANVELDKNPGYIKEIDALMEKVEAGDVRTIEHFDKAVSLAVAGIK
ETLLRLNVAHDKFVSESTFLKSGAVHDIVERIKATGRTKTDKGALVVDLSDYGFEKTLVIQRSNGTSLYTTRDLAYHEWK
AGQADRIIDVFGADHKLISGQLRATLNAIGVKEPEVVIFEFVSLPEGSMSTRRGQFISADDLFDRVTGAAFEQVETRRPE
TSYEFKKQVAEAVGLGAVRYDIVRVSPEKSTVFNWKEALDFEKQGAPYIQYSHARACSILEKAKEEAAWNPDKEIDPSLL
VEDSEIDLIKKMAMFDSVIDLGARELKPHVLAIYARELADAFNQFYRFVPVIAAEDENVRAARLALVDCARVVLANSLDT
LGIIAPESM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI197100773, Length=505, Percent_Identity=24.7524752475248, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI15149476, Length=589, Percent_Identity=23.0899830220713, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1788184, Length=589, Percent_Identity=27.8438030560272, Blast_Score=192, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71985061, Length=594, Percent_Identity=25.2525252525253, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985068, Length=569, Percent_Identity=24.4288224956063, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17532153, Length=507, Percent_Identity=24.2603550295858, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320548, Length=541, Percent_Identity=29.2051756007394, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321883, Length=542, Percent_Identity=27.1217712177122, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI18859963, Length=541, Percent_Identity=22.735674676525, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28571570, Length=486, Percent_Identity=22.4279835390947, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d [H]

EC number: =6.1.1.19 [H]

Molecular weight: Translated: 63055; Mature: 63055

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLELKAQATSILKEAIRKAGFEVEDSELQFETSPHADLASRAAFRLAGIHRQNPKDLAS
CEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHH
RIVSAVEIPEGSFIGKVSAAGPYINFFAGKHYLNGTVNAVLKEKEKFGCGAPKDRILLEH
HHHHHHCCCCCCCEEEECCCCCEEEEECCCHHCCCHHHHHHHHHHHCCCCCCCCCEEEEE
TSANPNGPLHVGHIRNSIIGDTLARILRRAGYDVEVQYYVNDMGRQIAVVSWACERFELD
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEHHHHHHEEE
LSRKSDSAIADVYIKANVELDKNPGYIKEIDALMEKVEAGDVRTIEHFDKAVSLAVAGIK
CCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ETLLRLNVAHDKFVSESTFLKSGAVHDIVERIKATGRTKTDKGALVVDLSDYGFEKTLVI
HHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEE
QRSNGTSLYTTRDLAYHEWKAGQADRIIDVFGADHKLISGQLRATLNAIGVKEPEVVIFE
EECCCCEEEEECCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
FVSLPEGSMSTRRGQFISADDLFDRVTGAAFEQVETRRPETSYEFKKQVAEAVGLGAVRY
EECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEE
DIVRVSPEKSTVFNWKEALDFEKQGAPYIQYSHARACSILEKAKEEAAWNPDKEIDPSLL
EEEEECCCCCHHCCHHHHCCHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VEDSEIDLIKKMAMFDSVIDLGARELKPHVLAIYARELADAFNQFYRFVPVIAAEDENVR
EECCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCH
AARLALVDCARVVLANSLDTLGIIAPESM
HHHHHHHHHHHHHHHCCCCCCEEECCCCC
>Mature Secondary Structure
MFLELKAQATSILKEAIRKAGFEVEDSELQFETSPHADLASRAAFRLAGIHRQNPKDLAS
CEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHH
RIVSAVEIPEGSFIGKVSAAGPYINFFAGKHYLNGTVNAVLKEKEKFGCGAPKDRILLEH
HHHHHHCCCCCCCEEEECCCCCEEEEECCCHHCCCHHHHHHHHHHHCCCCCCCCCEEEEE
TSANPNGPLHVGHIRNSIIGDTLARILRRAGYDVEVQYYVNDMGRQIAVVSWACERFELD
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEHHHHHHEEE
LSRKSDSAIADVYIKANVELDKNPGYIKEIDALMEKVEAGDVRTIEHFDKAVSLAVAGIK
CCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ETLLRLNVAHDKFVSESTFLKSGAVHDIVERIKATGRTKTDKGALVVDLSDYGFEKTLVI
HHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEE
QRSNGTSLYTTRDLAYHEWKAGQADRIIDVFGADHKLISGQLRATLNAIGVKEPEVVIFE
EECCCCEEEEECCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
FVSLPEGSMSTRRGQFISADDLFDRVTGAAFEQVETRRPETSYEFKKQVAEAVGLGAVRY
EECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEE
DIVRVSPEKSTVFNWKEALDFEKQGAPYIQYSHARACSILEKAKEEAAWNPDKEIDPSLL
EEEEECCCCCHHCCHHHHCCHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VEDSEIDLIKKMAMFDSVIDLGARELKPHVLAIYARELADAFNQFYRFVPVIAAEDENVR
EECCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCH
AARLALVDCARVVLANSLDTLGIIAPESM
HHHHHHHHHHHHHHHCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]