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The map label for this gene is tuaD [H]

Identifier: 21227234

GI number: 21227234

Start: 1335013

End: 1336266

Strand: Direct

Name: tuaD [H]

Synonym: MM_1132

Alternate gene names: 21227234

Gene position: 1335013-1336266 (Clockwise)

Preceding gene: 21227226

Following gene: 21227236

Centisome position: 32.59

GC content: 42.58

Gene sequence:

>1254_bases
GTGGGTTCGGTCACCGCTGCTTGCTTTGCAGAAGTCGGGCACGAAGTTATCTGCGTAGATATTGACAGGAAAAAAACGGA
GCAGATAAACGCAGGCATCCCTCCCATTTATGAAGAAGGACTTGGAGAGCTTTTGCAAAAATATGCAGGAAAAAAGCTCA
TAGCAATTACTGATTATGAACTTGCGGTCAAAGAGACAGAGATCTCCTTTATCTGTGTAGGGACACCTTCTGCAGATGAC
GGGACTATAGACCTTTCAATTGTCAGGGCAGCAGCAGCAAGTATAGGTAAAGCCCTTGCAAAAAAAGATGCTTATCATGT
AGTGGTGGTAAAAAGTACAGTAGTTCCTGAAACTACAGAAAAATTCGTCCTCCCCATTCTTGAGGAAACATCAGGAAAGA
AAGCCGGAAAAGACTTTGGTGTGGCAATGAATCCGGAGTTCCTGAGGGAAGGAAAGGCAGTCCAGGATTTTATGAACCCG
GATAAAATAGTGGTCGGTGCAATTGACAAAAGATCAGGAAATCTTGTTTCCGAGCTTTATCGCACATTTGAATGTGAGGT
CACGCGCACAGGCCCTGCAACTGCAGAAATGATAAAATATGCAAACAACTCCCTTCTTGCAACCAAGATTTCTTTTGCCA
ATGAAATAGGAAATATTTGCAAAAAAATGGGGATAGATACATATGAGGTCATGGAAGCAGTTGGTAAAGACTTCAGAATT
TCCCCGAAATTCCTGAACTCAGGGGCAGGTTTCGGAGGGTCCTGCTTCCCAAAGGACGTCAAAGCTCTTATAGGAAAAGC
AAAAACAATAGGATACTCTCCAGTACTACTTGAGTCCGTAATAGCTGTAAATGAGAAACAGCCTCTTCTTATGACCGAAA
TCCTGCAAAGAAAAATAGGAAACCCTGCGGACAAAAAGATTGCTGTTCTCGGACTTGCCTTCAAGAATGAAACTGACGAT
ATAAGAGAATCCAGGTCAATTCCTGTAATTGCCGAACTTCTTAGACTTGGGGCAAAAGTTTCAGCTTATGACCCGATGGC
AGCTGAAAACATGAAACGTATTTTCCCTTCAATCGAATACTGTGACAATGCCTCAGATGCGCTTAAAGATGCAGACGCCT
GTCTTGTGATGACAGAGTGGGATGAGTTCAGAAACCTTGACTCCGAATTCCAGAACATGAAAGAAAAAATAATTATTGAT
GGAAGGCGGATAATCAAAGCTAAAAATATTGATTATGAGGGGCTCTGCTGGTGA

Upstream 100 bases:

>100_bases
ACAGGCTATCAAAAAATAAATAAGAATTGGGATCGATTACCTGTCAATTCCCGAAAAAGAGGTCAAGATTATGAAAGTTT
CTGTTATAGGTTCAGGGTAT

Downstream 100 bases:

>100_bases
AAACCAGCAGGGTCAACCCTTTCCATATACCAATATCATAGATTTATTGTTTTTATTTATTTTTAAGTATCCTTTGTCTG
ATGCTTATTATATCCTGATT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MGSVTAACFAEVGHEVICVDIDRKKTEQINAGIPPIYEEGLGELLQKYAGKKLIAITDYELAVKETEISFICVGTPSADD
GTIDLSIVRAAAASIGKALAKKDAYHVVVVKSTVVPETTEKFVLPILEETSGKKAGKDFGVAMNPEFLREGKAVQDFMNP
DKIVVGAIDKRSGNLVSELYRTFECEVTRTGPATAEMIKYANNSLLATKISFANEIGNICKKMGIDTYEVMEAVGKDFRI
SPKFLNSGAGFGGSCFPKDVKALIGKAKTIGYSPVLLESVIAVNEKQPLLMTEILQRKIGNPADKKIAVLGLAFKNETDD
IRESRSIPVIAELLRLGAKVSAYDPMAAENMKRIFPSIEYCDNASDALKDADACLVMTEWDEFRNLDSEFQNMKEKIIID
GRRIIKAKNIDYEGLCW

Sequences:

>Translated_417_residues
MGSVTAACFAEVGHEVICVDIDRKKTEQINAGIPPIYEEGLGELLQKYAGKKLIAITDYELAVKETEISFICVGTPSADD
GTIDLSIVRAAAASIGKALAKKDAYHVVVVKSTVVPETTEKFVLPILEETSGKKAGKDFGVAMNPEFLREGKAVQDFMNP
DKIVVGAIDKRSGNLVSELYRTFECEVTRTGPATAEMIKYANNSLLATKISFANEIGNICKKMGIDTYEVMEAVGKDFRI
SPKFLNSGAGFGGSCFPKDVKALIGKAKTIGYSPVLLESVIAVNEKQPLLMTEILQRKIGNPADKKIAVLGLAFKNETDD
IRESRSIPVIAELLRLGAKVSAYDPMAAENMKRIFPSIEYCDNASDALKDADACLVMTEWDEFRNLDSEFQNMKEKIIID
GRRIIKAKNIDYEGLCW
>Mature_416_residues
GSVTAACFAEVGHEVICVDIDRKKTEQINAGIPPIYEEGLGELLQKYAGKKLIAITDYELAVKETEISFICVGTPSADDG
TIDLSIVRAAAASIGKALAKKDAYHVVVVKSTVVPETTEKFVLPILEETSGKKAGKDFGVAMNPEFLREGKAVQDFMNPD
KIVVGAIDKRSGNLVSELYRTFECEVTRTGPATAEMIKYANNSLLATKISFANEIGNICKKMGIDTYEVMEAVGKDFRIS
PKFLNSGAGFGGSCFPKDVKALIGKAKTIGYSPVLLESVIAVNEKQPLLMTEILQRKIGNPADKKIAVLGLAFKNETDDI
RESRSIPVIAELLRLGAKVSAYDPMAAENMKRIFPSIEYCDNASDALKDADACLVMTEWDEFRNLDSEFQNMKEKIIIDG
RRIIKAKNIDYEGLCW

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=437, Percent_Identity=33.4096109839817, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI296040438, Length=347, Percent_Identity=34.0057636887608, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI296040443, Length=290, Percent_Identity=35.8620689655172, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI48994968, Length=427, Percent_Identity=27.4004683840749, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788340, Length=342, Percent_Identity=25.4385964912281, Blast_Score=115, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17560350, Length=443, Percent_Identity=33.4085778781038, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17136908, Length=431, Percent_Identity=32.4825986078886, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 45605; Mature: 45474

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSVTAACFAEVGHEVICVDIDRKKTEQINAGIPPIYEEGLGELLQKYAGKKLIAITDYE
CCCHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCE
LAVKETEISFICVGTPSADDGTIDLSIVRAAAASIGKALAKKDAYHVVVVKSTVVPETTE
EEEEECCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
KFVLPILEETSGKKAGKDFGVAMNPEFLREGKAVQDFMNPDKIVVGAIDKRSGNLVSELY
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHH
RTFECEVTRTGPATAEMIKYANNSLLATKISFANEIGNICKKMGIDTYEVMEAVGKDFRI
HHHEEEEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
SPKFLNSGAGFGGSCFPKDVKALIGKAKTIGYSPVLLESVIAVNEKQPLLMTEILQRKIG
CHHHHCCCCCCCCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCC
NPADKKIAVLGLAFKNETDDIRESRSIPVIAELLRLGAKVSAYDPMAAENMKRIFPSIEY
CCCCCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHH
CDNASDALKDADACLVMTEWDEFRNLDSEFQNMKEKIIIDGRRIIKAKNIDYEGLCW
CCCCHHHHHCCCEEEEEECCHHHHCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
GSVTAACFAEVGHEVICVDIDRKKTEQINAGIPPIYEEGLGELLQKYAGKKLIAITDYE
CCHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCE
LAVKETEISFICVGTPSADDGTIDLSIVRAAAASIGKALAKKDAYHVVVVKSTVVPETTE
EEEEECCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
KFVLPILEETSGKKAGKDFGVAMNPEFLREGKAVQDFMNPDKIVVGAIDKRSGNLVSELY
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHH
RTFECEVTRTGPATAEMIKYANNSLLATKISFANEIGNICKKMGIDTYEVMEAVGKDFRI
HHHEEEEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
SPKFLNSGAGFGGSCFPKDVKALIGKAKTIGYSPVLLESVIAVNEKQPLLMTEILQRKIG
CHHHHCCCCCCCCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCC
NPADKKIAVLGLAFKNETDDIRESRSIPVIAELLRLGAKVSAYDPMAAENMKRIFPSIEY
CCCCCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHH
CDNASDALKDADACLVMTEWDEFRNLDSEFQNMKEKIIIDGRRIIKAKNIDYEGLCW
CCCCHHHHHCCCEEEEEECCHHHHCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]