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The map label for this gene is galE [C]

Identifier: 21227236

GI number: 21227236

Start: 1337476

End: 1338426

Strand: Direct

Name: galE [C]

Synonym: MM_1134

Alternate gene names: 21227236

Gene position: 1337476-1338426 (Clockwise)

Preceding gene: 21227234

Following gene: 21227240

Centisome position: 32.65

GC content: 42.17

Gene sequence:

>951_bases
ATGCCTGCGAAGAAAAGAGTACTTGTAACCGGAGGAGCCGGTTTTATAGGAAGCAATCTGGTAGACCGCCTTTTAGAAAA
AGAAAGTGAAGTCATTGTTTTCGATAATCTCAGTTCCGGAAAAATGGATTTTATAGAGAACCACCTTGAAAATCCGGATT
TTTCCTTTATAAAAGGAGACCTTCTTGATCCAGAAGCTATCGAAAAAGTCTGCAAGGATACTGATATGGTATACCATGTG
GCTGCAAATCCTGATGTAAAACTTGGCGCTTCGGACACGAAAGTCCATCTGGACCAGAATATCCTGGCAACCTACAATCT
CCTGGAGGCTATGAGAAAAGGCAGTGCAAAAAAGATTGCATTTACTTCTACGTCCACGGTCTATGGTGAAGCCAGTATTA
TGCCTACTCCGGAAAACTACGGCCCCCTTATCCCCATATCCCTTTATGGAGCTTCAAAGCTCGCCTGTGAAGCCCTCATT
ACCTCGTACTCCCATACCTTCGATATGCAGGCGTGGATTTTCCGTTTTGCAAATATTGTAGGGCCTCGTAGCACTCACGG
GATTACTGTTGATTTTATAAAAAAGCTTAAAGAAAATCCTCGCAAACTTGAGATACTGGGAGACGGAAAACAGGAAAAAT
CCTATTTACATGTCTCAGAATGTGTTAATGCGATCCTTTTTGCAATAGAAAAAAGTAAAGAAGAAGTGAATATCTTCAAT
ATCGGCTCTGAGGATACAATCAGCGCTACAGAGATAGGGAAAATCGTTGTTGAAGAGATGGGGCTTTCGGATGTGGAATT
TACATATACCGGAGGAAGCAGAGGCTGGAAAGGAGATGTTCCAAGAATGAGGCTTGGGATTGAAAAGTTAAAAGCCATAG
GATGGAAGCCTGAATATACTTCTGAAAGGAGTGTAAGAGAGACTGCCAGAGCAGTGATTGATAAAAGGTGA

Upstream 100 bases:

>100_bases
TTTCTATGCAAAGTCCCATATTGTATGAAAAAAGAATTACAGCTTTTGCAAAAAATAGTGCAAAGTATTAATAAAAAGAA
GAAGATTATCTGAGGATCAT

Downstream 100 bases:

>100_bases
TTAATAAAAGCTGAGATATTGCAAGAAGAAGATCTGTTTACTCCCTGAAGCAGTATTATATTACATCAAAGGATCAGATC
AATATTTTAAGATTGATATC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPAKKRVLVTGGAGFIGSNLVDRLLEKESEVIVFDNLSSGKMDFIENHLENPDFSFIKGDLLDPEAIEKVCKDTDMVYHV
AANPDVKLGASDTKVHLDQNILATYNLLEAMRKGSAKKIAFTSTSTVYGEASIMPTPENYGPLIPISLYGASKLACEALI
TSYSHTFDMQAWIFRFANIVGPRSTHGITVDFIKKLKENPRKLEILGDGKQEKSYLHVSECVNAILFAIEKSKEEVNIFN
IGSEDTISATEIGKIVVEEMGLSDVEFTYTGGSRGWKGDVPRMRLGIEKLKAIGWKPEYTSERSVRETARAVIDKR

Sequences:

>Translated_316_residues
MPAKKRVLVTGGAGFIGSNLVDRLLEKESEVIVFDNLSSGKMDFIENHLENPDFSFIKGDLLDPEAIEKVCKDTDMVYHV
AANPDVKLGASDTKVHLDQNILATYNLLEAMRKGSAKKIAFTSTSTVYGEASIMPTPENYGPLIPISLYGASKLACEALI
TSYSHTFDMQAWIFRFANIVGPRSTHGITVDFIKKLKENPRKLEILGDGKQEKSYLHVSECVNAILFAIEKSKEEVNIFN
IGSEDTISATEIGKIVVEEMGLSDVEFTYTGGSRGWKGDVPRMRLGIEKLKAIGWKPEYTSERSVRETARAVIDKR
>Mature_315_residues
PAKKRVLVTGGAGFIGSNLVDRLLEKESEVIVFDNLSSGKMDFIENHLENPDFSFIKGDLLDPEAIEKVCKDTDMVYHVA
ANPDVKLGASDTKVHLDQNILATYNLLEAMRKGSAKKIAFTSTSTVYGEASIMPTPENYGPLIPISLYGASKLACEALIT
SYSHTFDMQAWIFRFANIVGPRSTHGITVDFIKKLKENPRKLEILGDGKQEKSYLHVSECVNAILFAIEKSKEEVNIFNI
GSEDTISATEIGKIVVEEMGLSDVEFTYTGGSRGWKGDVPRMRLGIEKLKAIGWKPEYTSERSVRETARAVIDKR

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=317, Percent_Identity=27.4447949526814, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI42516563, Length=304, Percent_Identity=27.9605263157895, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI56237023, Length=278, Percent_Identity=26.6187050359712, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI56118217, Length=278, Percent_Identity=26.6187050359712, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI189083684, Length=278, Percent_Identity=26.6187050359712, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI193211614, Length=250, Percent_Identity=24, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8393516, Length=250, Percent_Identity=24, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786974, Length=262, Percent_Identity=29.7709923664122, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI48994969, Length=333, Percent_Identity=26.1261261261261, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788353, Length=337, Percent_Identity=26.4094955489614, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788589, Length=346, Percent_Identity=26.878612716763, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788366, Length=344, Percent_Identity=27.0348837209302, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790049, Length=251, Percent_Identity=25.8964143426295, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17568069, Length=262, Percent_Identity=32.0610687022901, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17539532, Length=325, Percent_Identity=27.3846153846154, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=26.3803680981595, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=279, Percent_Identity=26.8817204301075, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982038, Length=282, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=29.9120234604106, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=29.2993630573248, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19923002, Length=341, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35017; Mature: 34886

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKKRVLVTGGAGFIGSNLVDRLLEKESEVIVFDNLSSGKMDFIENHLENPDFSFIKGD
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEECC
LLDPEAIEKVCKDTDMVYHVAANPDVKLGASDTKVHLDQNILATYNLLEAMRKGSAKKIA
CCCHHHHHHHHCCCCEEEEEECCCCEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
FTSTSTVYGEASIMPTPENYGPLIPISLYGASKLACEALITSYSHTFDMQAWIFRFANIV
EECCCEEEECEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GPRSTHGITVDFIKKLKENPRKLEILGDGKQEKSYLHVSECVNAILFAIEKSKEEVNIFN
CCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEE
IGSEDTISATEIGKIVVEEMGLSDVEFTYTGGSRGWKGDVPRMRLGIEKLKAIGWKPEYT
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
SERSVRETARAVIDKR
CHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAKKRVLVTGGAGFIGSNLVDRLLEKESEVIVFDNLSSGKMDFIENHLENPDFSFIKGD
CCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEECC
LLDPEAIEKVCKDTDMVYHVAANPDVKLGASDTKVHLDQNILATYNLLEAMRKGSAKKIA
CCCHHHHHHHHCCCCEEEEEECCCCEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
FTSTSTVYGEASIMPTPENYGPLIPISLYGASKLACEALITSYSHTFDMQAWIFRFANIV
EECCCEEEECEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GPRSTHGITVDFIKKLKENPRKLEILGDGKQEKSYLHVSECVNAILFAIEKSKEEVNIFN
CCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEE
IGSEDTISATEIGKIVVEEMGLSDVEFTYTGGSRGWKGDVPRMRLGIEKLKAIGWKPEYT
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
SERSVRETARAVIDKR
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]