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The map label for this gene is kefC [H]

Identifier: 21227031

GI number: 21227031

Start: 1095109

End: 1097196

Strand: Direct

Name: kefC [H]

Synonym: MM_0929

Alternate gene names: 21227031

Gene position: 1095109-1097196 (Clockwise)

Preceding gene: 21227025

Following gene: 21227036

Centisome position: 26.73

GC content: 42.34

Gene sequence:

>2088_bases
ATGGAAGACTATTTGCTGGCAAATGTTGATGTGATTCTCGGCTTTGCAGTCGTAATTCTTACTATATTTTATAGATTTGA
ATTCCCTCCGATACTGGGCTTTCTTGTAACCGGGATGCTAATAGGGCCTTACGGTCTTGGAATCCTGAGCGGAGGGGAGA
TAGACATGACTTCCGAACTCGGAGTAGTCTTTCTGTTATTTACGATAGGAGTAGACCTCTCCTTAAATGACCTCTGGAAA
ATGAAAAAAGCCATAATGGGCGGAGGAGTTCTTCAGATCCTTTTTACAACAACTCTAGCTTTTATTATATGCACATGGAT
TGGATTCAGTTCTTCCACATCAATTTTTATAGGGCTCCTGATTTCACTTAGCAGTACCGCAATAGTACTCAAAGTTTTTC
AGGACAAAAACGAGGTTGATACCCCACACGGAAAAACTTCACTCGCAATTCTGATCTTTCAGGACCTTGCCATAGTCCCT
CTTATTCTTATAACTCCAATACTTGCAGGAAGTTCCATAAGTTTTGATGGAGCTTTTTCCAATATTTTCTTTAAAGGCTC
ACTGATCATCTTTGTTTTTATCCTGAGCTCCAGATTTCTGGTCCCCTGGATATTTTACTGTGTAGGCAGGACAGGCAGCA
AACAGTTATTCCTTGTCAGTGTTGTTTTTATATGCTTATCCGCAGCAGTCTTTACATCAAGCATTGGCCTCTCTTTAGCC
CTTGGAGCTTTTTTAGCCGGGATAGTCATCTCAGGGTCCCAGTACAGCCACCAGGCGATGGGAAATATCCTGCCTTTGAA
AGATATGTTCATGAGCTTTTTCTTTGTGTCCATAGGTATGCTTCTTAACATCAGCTACCTGCTTGATCATCTCCCTCTCC
TGGCTCTTGCTGCAGTCGCCCTTATTATTATAAAATCAATTGCAGGAATGCTTATCACCATTATTCTTGGATATCCTCTA
CGTACAACTATAATTACAGGGCTTGCACTTTCACAGGTGGGAGAGTTCTCATTTGTTCTTTCCAAACTGGGGCTGGAGTA
TTCCCTCCTGTCGAAGGAGACTTACCAGGCATTTCTGGCAGTTTCAATCATTACCATGGGAGTTACACCCTTTTTGATCA
ATGCCTCTTACAGGCCTGCTGAGTTCTTTGTCAAAAAGGCTTCAGACTCTGTATATGGCATGAAGCTCGTACGTGGCTTT
TGCTCAGGTTCCTTTGAATGGAAAGAATGCGTTGAACCTGAGATAAAAGATCATCTTATAATGGTAGGTTTTGGATTTTC
CGGAAAAACGATTTCAAAAGCTGCAAAAGCTGCAGGTATTCCATACATCATCCTGGAAACAAACCCCGATATTGTTAAGC
AGGAAAAAACAAAGGGTGAAAGAATACAGTACGGAGATGCAACATTCGGGGCTGTCCAGGAACATGCAGGAATCAGGAAC
GCAAGAGTGCTCATAACCGGAATATCCGATTCGGTTGCCACAAGAAAAATTGTAGAGAAGGCAAAAGAGTTGAATCCAAA
TATCTATGTAATTGCAAAGGTTCGGAACCTGCAGGAAATGAAGCACCTCCATCACCTGGGTGCGGATGAAATTATCCCTG
AAGAATACGAAACCTCAGTAGAAATATTTGTCCGCCTTCTCGAAAAGTATCTTGTGCCGAGGGAAAATATTGAAAAGATG
ATAAATGACTTGAGAGCTAACGGTTACAGAAGATTGAGAAAACTGTCAGTCGATCAGGATACAGATAATGAATTCAGCAT
AAAGGATGAGCTTCCGGGTGTTGAGATCCAGGTTCTTAAAGTGGGGAAAGGGTCAGGTTTTGACGGAAAAACCCTTGCAG
AGATGGAATTCAGGAAAAAGCACGGAGTAACAGTACTTTCTGTCCGCAGGGGCTCGGAAATGATTCACACTCCTGAAGGC
GATTTCCTTCTCAAAGCAAAAGATGCCTGCGTTCTTCTGGGAAAGCCTGAAAGCCTGCTCAATGTGAGAAAGTTGTTTGA
AAGCATCACCGGAGAAGTAAGACCTTCTTTTCAATCCGGGAGTAAAATTGAGCTGATCCCAAAACCGGATTCATTCCCAC
ATAACTAA

Upstream 100 bases:

>100_bases
TTTTCTAATTTCCAGTTTCAATACACCTTCATGAACTAATTGAGTAGACAATGACATCAATGACATAATTTATTTTTGCG
TTTTCCGGGGAGCGAAATAG

Downstream 100 bases:

>100_bases
AAGTTCAGAATTACTTAAATATTCAGGAATACAGACAGGCATTTTAAATTCGAGGTTAAGAGAAGTGGACTTAAATTCTG
GGACCAGCAACTATTATTGA

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MEDYLLANVDVILGFAVVILTIFYRFEFPPILGFLVTGMLIGPYGLGILSGGEIDMTSELGVVFLLFTIGVDLSLNDLWK
MKKAIMGGGVLQILFTTTLAFIICTWIGFSSSTSIFIGLLISLSSTAIVLKVFQDKNEVDTPHGKTSLAILIFQDLAIVP
LILITPILAGSSISFDGAFSNIFFKGSLIIFVFILSSRFLVPWIFYCVGRTGSKQLFLVSVVFICLSAAVFTSSIGLSLA
LGAFLAGIVISGSQYSHQAMGNILPLKDMFMSFFFVSIGMLLNISYLLDHLPLLALAAVALIIIKSIAGMLITIILGYPL
RTTIITGLALSQVGEFSFVLSKLGLEYSLLSKETYQAFLAVSIITMGVTPFLINASYRPAEFFVKKASDSVYGMKLVRGF
CSGSFEWKECVEPEIKDHLIMVGFGFSGKTISKAAKAAGIPYIILETNPDIVKQEKTKGERIQYGDATFGAVQEHAGIRN
ARVLITGISDSVATRKIVEKAKELNPNIYVIAKVRNLQEMKHLHHLGADEIIPEEYETSVEIFVRLLEKYLVPRENIEKM
INDLRANGYRRLRKLSVDQDTDNEFSIKDELPGVEIQVLKVGKGSGFDGKTLAEMEFRKKHGVTVLSVRRGSEMIHTPEG
DFLLKAKDACVLLGKPESLLNVRKLFESITGEVRPSFQSGSKIELIPKPDSFPHN

Sequences:

>Translated_695_residues
MEDYLLANVDVILGFAVVILTIFYRFEFPPILGFLVTGMLIGPYGLGILSGGEIDMTSELGVVFLLFTIGVDLSLNDLWK
MKKAIMGGGVLQILFTTTLAFIICTWIGFSSSTSIFIGLLISLSSTAIVLKVFQDKNEVDTPHGKTSLAILIFQDLAIVP
LILITPILAGSSISFDGAFSNIFFKGSLIIFVFILSSRFLVPWIFYCVGRTGSKQLFLVSVVFICLSAAVFTSSIGLSLA
LGAFLAGIVISGSQYSHQAMGNILPLKDMFMSFFFVSIGMLLNISYLLDHLPLLALAAVALIIIKSIAGMLITIILGYPL
RTTIITGLALSQVGEFSFVLSKLGLEYSLLSKETYQAFLAVSIITMGVTPFLINASYRPAEFFVKKASDSVYGMKLVRGF
CSGSFEWKECVEPEIKDHLIMVGFGFSGKTISKAAKAAGIPYIILETNPDIVKQEKTKGERIQYGDATFGAVQEHAGIRN
ARVLITGISDSVATRKIVEKAKELNPNIYVIAKVRNLQEMKHLHHLGADEIIPEEYETSVEIFVRLLEKYLVPRENIEKM
INDLRANGYRRLRKLSVDQDTDNEFSIKDELPGVEIQVLKVGKGSGFDGKTLAEMEFRKKHGVTVLSVRRGSEMIHTPEG
DFLLKAKDACVLLGKPESLLNVRKLFESITGEVRPSFQSGSKIELIPKPDSFPHN
>Mature_695_residues
MEDYLLANVDVILGFAVVILTIFYRFEFPPILGFLVTGMLIGPYGLGILSGGEIDMTSELGVVFLLFTIGVDLSLNDLWK
MKKAIMGGGVLQILFTTTLAFIICTWIGFSSSTSIFIGLLISLSSTAIVLKVFQDKNEVDTPHGKTSLAILIFQDLAIVP
LILITPILAGSSISFDGAFSNIFFKGSLIIFVFILSSRFLVPWIFYCVGRTGSKQLFLVSVVFICLSAAVFTSSIGLSLA
LGAFLAGIVISGSQYSHQAMGNILPLKDMFMSFFFVSIGMLLNISYLLDHLPLLALAAVALIIIKSIAGMLITIILGYPL
RTTIITGLALSQVGEFSFVLSKLGLEYSLLSKETYQAFLAVSIITMGVTPFLINASYRPAEFFVKKASDSVYGMKLVRGF
CSGSFEWKECVEPEIKDHLIMVGFGFSGKTISKAAKAAGIPYIILETNPDIVKQEKTKGERIQYGDATFGAVQEHAGIRN
ARVLITGISDSVATRKIVEKAKELNPNIYVIAKVRNLQEMKHLHHLGADEIIPEEYETSVEIFVRLLEKYLVPRENIEKM
INDLRANGYRRLRKLSVDQDTDNEFSIKDELPGVEIQVLKVGKGSGFDGKTLAEMEFRKKHGVTVLSVRRGSEMIHTPEG
DFLLKAKDACVLLGKPESLLNVRKLFESITGEVRPSFQSGSKIELIPKPDSFPHN

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=372, Percent_Identity=25.8064516129032, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1786232, Length=575, Percent_Identity=29.0434782608696, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1786685, Length=534, Percent_Identity=30.1498127340824, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789749, Length=580, Percent_Identity=28.7931034482759, Blast_Score=224, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 76382; Mature: 76382

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYLLANVDVILGFAVVILTIFYRFEFPPILGFLVTGMLIGPYGLGILSGGEIDMTSEL
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCHHH
GVVFLLFTIGVDLSLNDLWKMKKAIMGGGVLQILFTTTLAFIICTWIGFSSSTSIFIGLL
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ISLSSTAIVLKVFQDKNEVDTPHGKTSLAILIFQDLAIVPLILITPILAGSSISFDGAFS
HHHCCHHEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHH
NIFFKGSLIIFVFILSSRFLVPWIFYCVGRTGSKQLFLVSVVFICLSAAVFTSSIGLSLA
HEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFLAGIVISGSQYSHQAMGNILPLKDMFMSFFFVSIGMLLNISYLLDHLPLLALAAVA
HHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIIIKSIAGMLITIILGYPLRTTIITGLALSQVGEFSFVLSKLGLEYSLLSKETYQAFLA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VSIITMGVTPFLINASYRPAEFFVKKASDSVYGMKLVRGFCSGSFEWKECVEPEIKDHLI
HHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCEE
MVGFGFSGKTISKAAKAAGIPYIILETNPDIVKQEKTKGERIQYGDATFGAVQEHAGIRN
EEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEECCCHHHHHHHHCCCCC
ARVLITGISDSVATRKIVEKAKELNPNIYVIAKVRNLQEMKHLHHLGADEIIPEEYETSV
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHH
EIFVRLLEKYLVPRENIEKMINDLRANGYRRLRKLSVDQDTDNEFSIKDELPGVEIQVLK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEE
VGKGSGFDGKTLAEMEFRKKHGVTVLSVRRGSEMIHTPEGDFLLKAKDACVLLGKPESLL
ECCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEECCCCCEEEEECCCEEEECCCHHHH
NVRKLFESITGEVRPSFQSGSKIELIPKPDSFPHN
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MEDYLLANVDVILGFAVVILTIFYRFEFPPILGFLVTGMLIGPYGLGILSGGEIDMTSEL
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCHHH
GVVFLLFTIGVDLSLNDLWKMKKAIMGGGVLQILFTTTLAFIICTWIGFSSSTSIFIGLL
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ISLSSTAIVLKVFQDKNEVDTPHGKTSLAILIFQDLAIVPLILITPILAGSSISFDGAFS
HHHCCHHEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHH
NIFFKGSLIIFVFILSSRFLVPWIFYCVGRTGSKQLFLVSVVFICLSAAVFTSSIGLSLA
HEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFLAGIVISGSQYSHQAMGNILPLKDMFMSFFFVSIGMLLNISYLLDHLPLLALAAVA
HHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIIIKSIAGMLITIILGYPLRTTIITGLALSQVGEFSFVLSKLGLEYSLLSKETYQAFLA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VSIITMGVTPFLINASYRPAEFFVKKASDSVYGMKLVRGFCSGSFEWKECVEPEIKDHLI
HHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCEE
MVGFGFSGKTISKAAKAAGIPYIILETNPDIVKQEKTKGERIQYGDATFGAVQEHAGIRN
EEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEECCCHHHHHHHHCCCCC
ARVLITGISDSVATRKIVEKAKELNPNIYVIAKVRNLQEMKHLHHLGADEIIPEEYETSV
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHH
EIFVRLLEKYLVPRENIEKMINDLRANGYRRLRKLSVDQDTDNEFSIKDELPGVEIQVLK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEE
VGKGSGFDGKTLAEMEFRKKHGVTVLSVRRGSEMIHTPEGDFLLKAKDACVLLGKPESLL
ECCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEECCCCCEEEEECCCEEEECCCHHHH
NVRKLFESITGEVRPSFQSGSKIELIPKPDSFPHN
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA