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The map label for this gene is pphA [C]

Identifier: 21226853

GI number: 21226853

Start: 901679

End: 902380

Strand: Direct

Name: pphA [C]

Synonym: MM_0751

Alternate gene names: 21226853

Gene position: 901679-902380 (Clockwise)

Preceding gene: 21226852

Following gene: 21226855

Centisome position: 22.01

GC content: 47.15

Gene sequence:

>702_bases
ATGAGACTGTTACTGATCGCTGATATACATGGAAATTATGAAGCTCTCCGGACAGTTCTAGATGTCCCTTATGACAGGGC
AGTCTGCCTTGGAGATATCGTGGACTACGGGCCTGACCCGGACAGGTGCATAGACCTCCTGCAAAAAAAGAATATCACTA
CCATCAGGGGTAATCACGACAATGCGGTTGCCTTTAAAGTGGACTGCCAGTGTGGTTACAGGTACAAACATCTCTCAATT
GCAACCCGGGAATATACCTGGAAAATTCTTGACAGAGCAGGGATGAAGTACCTGCAAAAACTTCCTCTGCTGATCAAAGA
AGAAATTGACGGAAAAAGTTTTTACTTTACCCACGGGAGCCCGCGCTCCATGTTCGAATACATAAAACCCGAAACCTCCG
ATGAAGAGGTTTTGAGAATGATAGAAGGAGCAGCAGAGCCTGTGGAGGCTGAGTTTCTCGTTGTCGGACACTCTCACATT
CCCATGAACCGAAAAATAGGAAACCTTACAATAATAAATCCGGGTTCAGCAGGACAGCCAAGAGACGGAGATACAGGGGC
GAGCTGTGCTGTTTTCGATACTGAAACAGGAGAGGTGGAGTTCCTGCATCTGAAGTATGACATTGATGCGGTCTGCGCCA
AAATAGAAGAAAGAATGCCTCACGCAGAGGAGCTGACAGGAATCCTCAGGCGGGGATATTGA

Upstream 100 bases:

>100_bases
GCTTGTAATGGGAATTGGAATGCGCAGACTCCACGGCTGAAAGCTCGGAATGAAAAGAAAAATTAGAATCCAGAGGAAGT
AAAAACCGAAAGGGGAAATA

Downstream 100 bases:

>100_bases
GGAAAAGGTACGTTAAAGGAAAAAACCGCAGAAAGAAGATAATAAGAAAAAGAGAACGATAAGTCAAGCTTAAAAAAGAA
AAAAGTGAAGATAAAGGTCA

Product: putative serine/threonine protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRLLLIADIHGNYEALRTVLDVPYDRAVCLGDIVDYGPDPDRCIDLLQKKNITTIRGNHDNAVAFKVDCQCGYRYKHLSI
ATREYTWKILDRAGMKYLQKLPLLIKEEIDGKSFYFTHGSPRSMFEYIKPETSDEEVLRMIEGAAEPVEAEFLVVGHSHI
PMNRKIGNLTIINPGSAGQPRDGDTGASCAVFDTETGEVEFLHLKYDIDAVCAKIEERMPHAEELTGILRRGY

Sequences:

>Translated_233_residues
MRLLLIADIHGNYEALRTVLDVPYDRAVCLGDIVDYGPDPDRCIDLLQKKNITTIRGNHDNAVAFKVDCQCGYRYKHLSI
ATREYTWKILDRAGMKYLQKLPLLIKEEIDGKSFYFTHGSPRSMFEYIKPETSDEEVLRMIEGAAEPVEAEFLVVGHSHI
PMNRKIGNLTIINPGSAGQPRDGDTGASCAVFDTETGEVEFLHLKYDIDAVCAKIEERMPHAEELTGILRRGY
>Mature_233_residues
MRLLLIADIHGNYEALRTVLDVPYDRAVCLGDIVDYGPDPDRCIDLLQKKNITTIRGNHDNAVAFKVDCQCGYRYKHLSI
ATREYTWKILDRAGMKYLQKLPLLIKEEIDGKSFYFTHGSPRSMFEYIKPETSDEEVLRMIEGAAEPVEAEFLVVGHSHI
PMNRKIGNLTIINPGSAGQPRDGDTGASCAVFDTETGEVEFLHLKYDIDAVCAKIEERMPHAEELTGILRRGY

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR011152 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 26335; Mature: 26335

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLIADIHGNYEALRTVLDVPYDRAVCLGDIVDYGPDPDRCIDLLQKKNITTIRGNHD
CEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
NAVAFKVDCQCGYRYKHLSIATREYTWKILDRAGMKYLQKLPLLIKEEIDGKSFYFTHGS
CEEEEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCC
PRSMFEYIKPETSDEEVLRMIEGAAEPVEAEFLVVGHSHIPMNRKIGNLTIINPGSAGQP
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCC
RDGDTGASCAVFDTETGEVEFLHLKYDIDAVCAKIEERMPHAEELTGILRRGY
CCCCCCCEEEEEECCCCCEEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRLLLIADIHGNYEALRTVLDVPYDRAVCLGDIVDYGPDPDRCIDLLQKKNITTIRGNHD
CEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
NAVAFKVDCQCGYRYKHLSIATREYTWKILDRAGMKYLQKLPLLIKEEIDGKSFYFTHGS
CEEEEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCC
PRSMFEYIKPETSDEEVLRMIEGAAEPVEAEFLVVGHSHIPMNRKIGNLTIINPGSAGQP
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCC
RDGDTGASCAVFDTETGEVEFLHLKYDIDAVCAKIEERMPHAEELTGILRRGY
CCCCCCCEEEEEECCCCCEEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]