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The map label for this gene is mutL

Identifier: 209696185

GI number: 209696185

Start: 3008413

End: 3010371

Strand: Reverse

Name: mutL

Synonym: VSAL_I2779

Alternate gene names: 209696185

Gene position: 3010371-3008413 (Counterclockwise)

Preceding gene: 209696186

Following gene: 209696184

Centisome position: 90.53

GC content: 39.56

Gene sequence:

>1959_bases
ATGCCAATTCAAATCTTACCCGCTCGACTGGCCAACCAAATTGCGGCGGGTGAGGTTGTGGAACGCCCCGCTTCGGTTGT
CAAAGAATTGGTTGAAAATAGTATCGATGCCGGAGCGACTCGCATCGATATTGATATCGAAAAAGGGGGCAGTAAACTCA
TTCGCATCCGTGATAATGGGTCTGGTATCCCTAAAGAAGAACTGACATTAGCATTAAGCCGTCACGCGACCTCAAAAATT
ACGACTCTTGATGATCTTGAAGCGATTGTCAGTTTAGGGTTTCGTGGTGAAGCTTTAGCGTCAATCAGCTCTGTTTCTCG
ATTAACGCTTACCTCACGCACTGTTGCACAAGAAGAAGCGTGGTCTGCACATGCTGAAGGGCGAGATATGGAGGTTAAAT
TAAAACCAGCCGCTCACCCTGTTGGGACAACCATCGATGTTGTCGATCTATTCTTCAATACTCCTGCCCGTCGAAAATTT
CTTCGTACCGATAAAACTGAATTTACTCATATTGATGAATTGCTTAAGCGTATTGCATTGAGTCGATTAGATATTACGAT
CAATTTACGTCATAACGGTAAATCGGTTCGTCAATACCGAGCAGCTCAAACGAAAATGCAAGTAGAGAAACGTTTAGCTG
CCGTATGTGGAGCGAGTTTCTTACAGCATGCATTAGAAGTTGAGTTGGAGCATGGAGACTTAATCTTTCATGGATGGATT
TCATCTCCAGAAGGTGCCCGTGCCCAAGGTGATGTTCAATATTGCTATGTGAATGGTCGTATGATGAAAGATAAGTTGAT
TAATCATGCAATTCGTCAAGGGTATGAATCAAGCCTTTCTACGAATCAGTATGCGGCTTATATTTTATTTATCGAGATAA
ATCCACATGACGTAGATGTGAATGTTCATCCAGCAAAGCACGAGGTGAGGTTTCACCAAGCACGGTTAGTGCATGATTTT
ATATACCAAGCTATTTATGGTGCTTTGCAACAGGCAGCATCTTTACCTGAAGTAACAACGACATCAGATATTGAAATGGA
TAGGGAATCTTATTTTCCACCAATGAAAGATTATGTTCGTCAGTCTTCTCTGCCACTAACTGATGCTCATATTGAGAACA
AATCGAAGCAATTGAAAGAAGCAATCGAAGCAACACCGAGTTACCCAAATAAAGCGTCTTCAGATGAGTGGGTATCTAAA
GCAAAACCATCAATGCCTAAAGCGTATCAAAGTGAAAAACCGTCCCAAAGAGAATTGAATAACTACCAACATTTATTAAC
AACGCGAGATCGTGAAGACAAAACATCTAATTTTGAAGTTAATGAAGTACGGATCCCTAAGATTTCAGAGGCTAAACATA
ACACTGTTGTTGTGCCTCAATTGAAAAGTGCGGTGTCGACTTCTATGCTATTAGGGAAAGTGTTAAGTGTTGTTGATAAG
GTGTTTGGGCTGCTTCAATTAGGTAATCAATTGCAATTGGTTGATCTACGCTATGCTGAATTTATCAAAAGTTATGGCCA
ATTAAACTCGGCTCATCATGAAGTGTTAAAAGCTCAGCCGTTATTGATTCCATTATCGATAGGGATTGATAAAGATATTT
GTAACAAACTCACAGAGTATCAAGGTATATTGAAACAACTTGGTATTGATCTTAAAGTGAAAAATAATGAAAGTTTGATA
GTTATGGCGGTTTGTCAGCCTATCAGGCAACAGAATTTACAACAATTGATCCCGAATCTGTTAAGGTATATTTATCAGAT
TAATCCATCGTTGGATCAAGTGATTAGCTGGCTTTCTCATCAAGTACAACATGATGAAGCGTGCTATAGCTCAGCACAAG
CAATACAACTTGTGATGGAATTAGAGCAGTTGTGGGGTAATGAATTATCTCAATTTAATAATAAACTGCTAAAAAACATA
GATATTACTCAGGCGATACAAGCATTTAGTCATGAATAA

Upstream 100 bases:

>100_bases
TTACTGTATCGAGTATACGAACAGCCAATAAATTACGTTCAGATGAGCTAGCTGTCGGACAGGTGCTTATTATCCCAACC
AGTTAATCAAGGATATGGTT

Downstream 100 bases:

>100_bases
AGCATTACCTCAAGCCATCTTTTTGATGGGACCAACTGCATCAGGGAAAACGGACTTAGCAATTCAATTGCGAAAACGTT
TTCCTGTGGAGTTGATAAGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKEELTLALSRHATSKI
TTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAHAEGRDMEVKLKPAAHPVGTTIDVVDLFFNTPARRKF
LRTDKTEFTHIDELLKRIALSRLDITINLRHNGKSVRQYRAAQTKMQVEKRLAAVCGASFLQHALEVELEHGDLIFHGWI
SSPEGARAQGDVQYCYVNGRMMKDKLINHAIRQGYESSLSTNQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDF
IYQAIYGALQQAASLPEVTTTSDIEMDRESYFPPMKDYVRQSSLPLTDAHIENKSKQLKEAIEATPSYPNKASSDEWVSK
AKPSMPKAYQSEKPSQRELNNYQHLLTTRDREDKTSNFEVNEVRIPKISEAKHNTVVVPQLKSAVSTSMLLGKVLSVVDK
VFGLLQLGNQLQLVDLRYAEFIKSYGQLNSAHHEVLKAQPLLIPLSIGIDKDICNKLTEYQGILKQLGIDLKVKNNESLI
VMAVCQPIRQQNLQQLIPNLLRYIYQINPSLDQVISWLSHQVQHDEACYSSAQAIQLVMELEQLWGNELSQFNNKLLKNI
DITQAIQAFSHE

Sequences:

>Translated_652_residues
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKEELTLALSRHATSKI
TTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAHAEGRDMEVKLKPAAHPVGTTIDVVDLFFNTPARRKF
LRTDKTEFTHIDELLKRIALSRLDITINLRHNGKSVRQYRAAQTKMQVEKRLAAVCGASFLQHALEVELEHGDLIFHGWI
SSPEGARAQGDVQYCYVNGRMMKDKLINHAIRQGYESSLSTNQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDF
IYQAIYGALQQAASLPEVTTTSDIEMDRESYFPPMKDYVRQSSLPLTDAHIENKSKQLKEAIEATPSYPNKASSDEWVSK
AKPSMPKAYQSEKPSQRELNNYQHLLTTRDREDKTSNFEVNEVRIPKISEAKHNTVVVPQLKSAVSTSMLLGKVLSVVDK
VFGLLQLGNQLQLVDLRYAEFIKSYGQLNSAHHEVLKAQPLLIPLSIGIDKDICNKLTEYQGILKQLGIDLKVKNNESLI
VMAVCQPIRQQNLQQLIPNLLRYIYQINPSLDQVISWLSHQVQHDEACYSSAQAIQLVMELEQLWGNELSQFNNKLLKNI
DITQAIQAFSHE
>Mature_651_residues
PIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKEELTLALSRHATSKIT
TLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAHAEGRDMEVKLKPAAHPVGTTIDVVDLFFNTPARRKFL
RTDKTEFTHIDELLKRIALSRLDITINLRHNGKSVRQYRAAQTKMQVEKRLAAVCGASFLQHALEVELEHGDLIFHGWIS
SPEGARAQGDVQYCYVNGRMMKDKLINHAIRQGYESSLSTNQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDFI
YQAIYGALQQAASLPEVTTTSDIEMDRESYFPPMKDYVRQSSLPLTDAHIENKSKQLKEAIEATPSYPNKASSDEWVSKA
KPSMPKAYQSEKPSQRELNNYQHLLTTRDREDKTSNFEVNEVRIPKISEAKHNTVVVPQLKSAVSTSMLLGKVLSVVDKV
FGLLQLGNQLQLVDLRYAEFIKSYGQLNSAHHEVLKAQPLLIPLSIGIDKDICNKLTEYQGILKQLGIDLKVKNNESLIV
MAVCQPIRQQNLQQLIPNLLRYIYQINPSLDQVISWLSHQVQHDEACYSSAQAIQLVMELEQLWGNELSQFNNKLLKNID
ITQAIQAFSHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=35.7357357357357, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=30.8176100628931, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=30.8176100628931, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI189458896, Length=310, Percent_Identity=31.2903225806452, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=27.1428571428571, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=27.1428571428571, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI263191589, Length=221, Percent_Identity=32.1266968325792, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI91992162, Length=379, Percent_Identity=24.2744063324538, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992160, Length=379, Percent_Identity=24.2744063324538, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310128480, Length=303, Percent_Identity=24.4224422442244, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790612, Length=656, Percent_Identity=48.780487804878, Blast_Score=595, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=35.9133126934984, Blast_Score=179, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=28.4883720930233, Blast_Score=133, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=371, Percent_Identity=34.7708894878706, Blast_Score=190, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=343, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=283, Percent_Identity=28.9752650176678, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=171, Percent_Identity=30.4093567251462, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136968, Length=324, Percent_Identity=33.641975308642, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=28.5302593659942, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_ALISL (B6EMQ9)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264115.1
- GeneID:   6988803
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2779
- HOGENOM:   HBG520262
- OMA:   NGRMMKD
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 73308; Mature: 73176

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKEELTLALSRHATSKITTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAHAEGRDMEVKLKPAAHPVGTTIDVVDLFFNTPARRKFLRTDKTEFTHIDELLKRIAL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
SRLDITINLRHNGKSVRQYRAAQTKMQVEKRLAAVCGASFLQHALEVELEHGDLIFHGWI
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECC
SSPEGARAQGDVQYCYVNGRMMKDKLINHAIRQGYESSLSTNQYAAYILFIEINPHDVDV
CCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHCHHHCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAIYGALQQAASLPEVTTTSDIEMDRESYFPPMKDYVR
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHH
QSSLPLTDAHIENKSKQLKEAIEATPSYPNKASSDEWVSKAKPSMPKAYQSEKPSQRELN
HCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCHHHHH
NYQHLLTTRDREDKTSNFEVNEVRIPKISEAKHNTVVVPQLKSAVSTSMLLGKVLSVVDK
HHHHHHHCCCCCCCCCCEEECEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHH
VFGLLQLGNQLQLVDLRYAEFIKSYGQLNSAHHEVLKAQPLLIPLSIGIDKDICNKLTEY
HHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
QGILKQLGIDLKVKNNESLIVMAVCQPIRQQNLQQLIPNLLRYIYQINPSLDQVISWLSH
HHHHHHCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QVQHDEACYSSAQAIQLVMELEQLWGNELSQFNNKLLKNIDITQAIQAFSHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
PIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNG
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKEELTLALSRHATSKITTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAHAEGRDMEVKLKPAAHPVGTTIDVVDLFFNTPARRKFLRTDKTEFTHIDELLKRIAL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
SRLDITINLRHNGKSVRQYRAAQTKMQVEKRLAAVCGASFLQHALEVELEHGDLIFHGWI
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECC
SSPEGARAQGDVQYCYVNGRMMKDKLINHAIRQGYESSLSTNQYAAYILFIEINPHDVDV
CCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHCHHHCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAIYGALQQAASLPEVTTTSDIEMDRESYFPPMKDYVR
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHH
QSSLPLTDAHIENKSKQLKEAIEATPSYPNKASSDEWVSKAKPSMPKAYQSEKPSQRELN
HCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCHHHHH
NYQHLLTTRDREDKTSNFEVNEVRIPKISEAKHNTVVVPQLKSAVSTSMLLGKVLSVVDK
HHHHHHHCCCCCCCCCCEEECEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHH
VFGLLQLGNQLQLVDLRYAEFIKSYGQLNSAHHEVLKAQPLLIPLSIGIDKDICNKLTEY
HHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
QGILKQLGIDLKVKNNESLIVMAVCQPIRQQNLQQLIPNLLRYIYQINPSLDQVISWLSH
HHHHHHCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QVQHDEACYSSAQAIQLVMELEQLWGNELSQFNNKLLKNIDITQAIQAFSHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA