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The map label for this gene is parC [H]

Identifier: 209696077

GI number: 209696077

Start: 2886649

End: 2888919

Strand: Reverse

Name: parC [H]

Synonym: VSAL_I2669

Alternate gene names: 209696077

Gene position: 2888919-2886649 (Counterclockwise)

Preceding gene: 209696078

Following gene: 209696073

Centisome position: 86.88

GC content: 41.04

Gene sequence:

>2271_bases
ATGAGTGCAGAAATGTCCTTAGAAGGTGTTGAACAGCTGCCGCTGCGCAAGTTTACAGAAGACGCTTATCTAAATTACTC
CATGTACGTAATCATGGATCGCGCGTTACCTTATATTGGTGATGGTTTAAAACCGGTTCAACGTCGTATTATTTTTGCGA
TGTCTGAATTAGGTTTGTCTGCGAATGCAAAATACAAAAAATCGGCACGTACAGTTGGTGATGTACTCGGTAAGTATCAC
CCACATGGTGATTCTGCGTGTTACGAAGCCATGGTATTAATGGCTCAACCTTTCTCTTATCGTTATCCATTGGTTGATGG
TCAAGGCAACTGGGGGGCTCCAGATGACCCTAAGTCGTTCGCCGCAATGCGTTATACAGAATCAAAACTGTCTAAGTTTG
CCGATGTATTACTTGGTGAGATAAGCCAAGGTACGGTTGATTGGCAGCCCAATTTTGATGGGACGATGAAAGAGCCAAAA
ATCTTACCAGCACGTCTGCCTCATATATTACTGAACGGTATTATGGGAATCGCGGTTGGTATGGCGACAGATATCCCACC
TCATAATGTACGTGAAGTTGCGAATGCGACCGTGCATTTATTGGATAATCCAAAAGCGGATTTAGATGAAGTGATGAACT
TTATCCAAGGCCCTGATTACCCAACAGAAGCGGAAATCATTACATCGCATTCTGATATTAAGAAGATTTACAGTACGGGT
CGAGGCAGCGTTAAAATGCGCGCAGTGTGGCATAAAGAAGGCAGTGATATTGTTATTACTGCATTGCCACATCAAGTGTC
GGGCAGTAAGTTATTAGAACAAATTGCCAATCAAATGCGAGCGAAGAAATTACCAATGGTAGACGATCTTCGTGATGAAT
CGGATCATGAAAATCCGACACGTATCGTGATTGTTCCTCGTTCAAATCGTATTGAAGCTGAGCCATTAATGAATCATCTA
TTTGCTTCTACGGATCTTGAAAAGAGTTTCCGTGTAAACTTAAATATGATTGGTTTGGATTTACGTCCACAGGTGAAGGG
CTTAGTTAGCATTCTTAATGAATGGATTGAATTTCGTCGCACCACGGTACGTAAACGTCTGCAGCATCGTCTAGATAAAA
TATTAGCGCGTTTGCATATTTTAGATGGTTTGCTTGCTGCGTATTTGAATATCGATGAAGTTATCGAAATTATTCGTACA
GAAGACGATCCTAAACACGAGTTAATGACTCGCTTTGATTTAACCGCGATTCAAGCGGAAGCCATTTTAGAGATTAAACT
TCGTCAGTTAGCAAAACTGGAAGAGATTAAGATTCGTGGCGAGCAAGATGAATTAGCGAAAGAGCGTGATCAACTTGAGA
AACTGTTGGGTTCTGAGCGTCGTTTAAGTACGTTAATTAAGAAAGAAATCTTAGCCGATGCTGAAAAGTTTGGTGATGAT
CGTCGTTCTCCATTAATCGAACGTGATGAAGCGAAAGCAATGACGGAACGTGATCTAATTCCAAGTGAAGCGATTACGGT
TATTCTTTCTGATAAAGGTTGGATACGTCATGCAAAAGGTCATGAGGTTGATCCAACAACGCTAAACTTTAAATCTGGTG
ATAAATACCTTACTCATGCTCATGGTAAGAGTAATGCACCGGCGGTCTTTATCGGAAATAATGGTCGAAGTTATGCGCTT
GAATCACATACATTACCGTCAGCAAGAAGCCAAGGCGAGCCAATTACAGGTCGTCTAAATATTACTGCTGGTAGCCAAAT
TACGCATGTAGTTATGGGTGAAGAAGATCAAACGTGGTTAATCAGTTCTGATGCGGGTTATGGTTTTGTCTGTAAAGGCA
GTGACTTATTATCAAAGAATAAGAATGGTAAAACATTGTTAACGCTTCCTGATAATTCTTTAGTTATGAATCCAGAGACG
GTATCGGATCTTGATAGCGATGAGATACTCGCCATTACGAATGAAGGCAGAATGCTTCTGTTCCCTATTAAAGATTTACC
TCAATTAGGTAAAGGTAAGGGAAACAAGATCATTAATATTCCAGCGGCTCGTTCTAAATCGCGAGATGAATTCTTGTCTT
ATTTATTGCCATTACCTCAAGGCGCAACGATTACCCTCTATGCAGGTAAGCGTAAATTAGGCTTGAAACCAAGTGATTTA
GATAATTTCCGAGGTGAGCGTGGCCGTCGTGGTAGTTTGTTACCAAGAGGCTTACAGCGAGTTACTCGTATTGATATCAA
TGGTGACAATGGTTCTACAGAAGAGAGTTAA

Upstream 100 bases:

>100_bases
AAAAACTAATGAAATGATGGATATGCTTTTAGGTAAAAAACGTGCTGACGATCGTCGAGCTTGGTTACAATCTAATGGCG
ATCTGGCAGAGGTATAACAA

Downstream 100 bases:

>100_bases
GCACTCTCGATAGAGCGATTGAATCGTTAATAAAAAATAGCGCATGATGAATGCGCTATTTTTTTATTTCGATATTTCGA
TATTTCGATATTTCGATATT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MSAEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIFAMSELGLSANAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEISQGTVDWQPNFDGTMKEPK
ILPARLPHILLNGIMGIAVGMATDIPPHNVREVANATVHLLDNPKADLDEVMNFIQGPDYPTEAEIITSHSDIKKIYSTG
RGSVKMRAVWHKEGSDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRIEAEPLMNHL
FASTDLEKSFRVNLNMIGLDLRPQVKGLVSILNEWIEFRRTTVRKRLQHRLDKILARLHILDGLLAAYLNIDEVIEIIRT
EDDPKHELMTRFDLTAIQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDQLEKLLGSERRLSTLIKKEILADAEKFGDD
RRSPLIERDEAKAMTERDLIPSEAITVILSDKGWIRHAKGHEVDPTTLNFKSGDKYLTHAHGKSNAPAVFIGNNGRSYAL
ESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEDQTWLISSDAGYGFVCKGSDLLSKNKNGKTLLTLPDNSLVMNPET
VSDLDSDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSRDEFLSYLLPLPQGATITLYAGKRKLGLKPSDL
DNFRGERGRRGSLLPRGLQRVTRIDINGDNGSTEES

Sequences:

>Translated_756_residues
MSAEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIFAMSELGLSANAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEISQGTVDWQPNFDGTMKEPK
ILPARLPHILLNGIMGIAVGMATDIPPHNVREVANATVHLLDNPKADLDEVMNFIQGPDYPTEAEIITSHSDIKKIYSTG
RGSVKMRAVWHKEGSDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRIEAEPLMNHL
FASTDLEKSFRVNLNMIGLDLRPQVKGLVSILNEWIEFRRTTVRKRLQHRLDKILARLHILDGLLAAYLNIDEVIEIIRT
EDDPKHELMTRFDLTAIQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDQLEKLLGSERRLSTLIKKEILADAEKFGDD
RRSPLIERDEAKAMTERDLIPSEAITVILSDKGWIRHAKGHEVDPTTLNFKSGDKYLTHAHGKSNAPAVFIGNNGRSYAL
ESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEDQTWLISSDAGYGFVCKGSDLLSKNKNGKTLLTLPDNSLVMNPET
VSDLDSDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSRDEFLSYLLPLPQGATITLYAGKRKLGLKPSDL
DNFRGERGRRGSLLPRGLQRVTRIDINGDNGSTEES
>Mature_755_residues
SAEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIFAMSELGLSANAKYKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESKLSKFADVLLGEISQGTVDWQPNFDGTMKEPKI
LPARLPHILLNGIMGIAVGMATDIPPHNVREVANATVHLLDNPKADLDEVMNFIQGPDYPTEAEIITSHSDIKKIYSTGR
GSVKMRAVWHKEGSDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVIVPRSNRIEAEPLMNHLF
ASTDLEKSFRVNLNMIGLDLRPQVKGLVSILNEWIEFRRTTVRKRLQHRLDKILARLHILDGLLAAYLNIDEVIEIIRTE
DDPKHELMTRFDLTAIQAEAILEIKLRQLAKLEEIKIRGEQDELAKERDQLEKLLGSERRLSTLIKKEILADAEKFGDDR
RSPLIERDEAKAMTERDLIPSEAITVILSDKGWIRHAKGHEVDPTTLNFKSGDKYLTHAHGKSNAPAVFIGNNGRSYALE
SHTLPSARSQGEPITGRLNITAGSQITHVVMGEEDQTWLISSDAGYGFVCKGSDLLSKNKNGKTLLTLPDNSLVMNPETV
SDLDSDEILAITNEGRMLLFPIKDLPQLGKGKGNKIINIPAARSKSRDEFLSYLLPLPQGATITLYAGKRKLGLKPSDLD
NFRGERGRRGSLLPRGLQRVTRIDINGDNGSTEES

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789396, Length=749, Percent_Identity=67.022696929239, Blast_Score=1071, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=747, Percent_Identity=34.805890227577, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=394, Percent_Identity=23.6040609137056, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=211, Percent_Identity=26.0663507109005, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84434; Mature: 84303

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIFAMSELGLS
CCCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCC
ANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTESKLSKFADVLLGEISQGTVDWQPNFDGTMKEPKILPARLPHILLNGIMGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MATDIPPHNVREVANATVHLLDNPKADLDEVMNFIQGPDYPTEAEIITSHSDIKKIYSTG
HCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHCC
RGSVKMRAVWHKEGSDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVIVPRSNRIEAEPLMNHLFASTDLEKSFRVNLNMIGLDLRPQVKGLVSILNEWIEFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
TTVRKRLQHRLDKILARLHILDGLLAAYLNIDEVIEIIRTEDDPKHELMTRFDLTAIQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AILEIKLRQLAKLEEIKIRGEQDELAKERDQLEKLLGSERRLSTLIKKEILADAEKFGDD
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLIERDEAKAMTERDLIPSEAITVILSDKGWIRHAKGHEVDPTTLNFKSGDKYLTHA
CCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCEEEECCCCCEEEEC
HGKSNAPAVFIGNNGRSYALESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEDQTWL
CCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCEEE
ISSDAGYGFVCKGSDLLSKNKNGKTLLTLPDNSLVMNPETVSDLDSDEILAITNEGRMLL
EECCCCCEEEECCCHHHCCCCCCCEEEEECCCCEEECCHHHCCCCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAARSKSRDEFLSYLLPLPQGATITLYAGKRKLGLKPSDL
EECCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCEECCCCCCCC
DNFRGERGRRGSLLPRGLQRVTRIDINGDNGSTEES
HHHCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure 
SAEMSLEGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIFAMSELGLS
CCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCC
ANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTESKLSKFADVLLGEISQGTVDWQPNFDGTMKEPKILPARLPHILLNGIMGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MATDIPPHNVREVANATVHLLDNPKADLDEVMNFIQGPDYPTEAEIITSHSDIKKIYSTG
HCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHCC
RGSVKMRAVWHKEGSDIVITALPHQVSGSKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVIVPRSNRIEAEPLMNHLFASTDLEKSFRVNLNMIGLDLRPQVKGLVSILNEWIEFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
TTVRKRLQHRLDKILARLHILDGLLAAYLNIDEVIEIIRTEDDPKHELMTRFDLTAIQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AILEIKLRQLAKLEEIKIRGEQDELAKERDQLEKLLGSERRLSTLIKKEILADAEKFGDD
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLIERDEAKAMTERDLIPSEAITVILSDKGWIRHAKGHEVDPTTLNFKSGDKYLTHA
CCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCEEEECCCCCEEEEC
HGKSNAPAVFIGNNGRSYALESHTLPSARSQGEPITGRLNITAGSQITHVVMGEEDQTWL
CCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCEEE
ISSDAGYGFVCKGSDLLSKNKNGKTLLTLPDNSLVMNPETVSDLDSDEILAITNEGRMLL
EECCCCCEEEECCCHHHCCCCCCCEEEEECCCCEEECCHHHCCCCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAARSKSRDEFLSYLLPLPQGATITLYAGKRKLGLKPSDL
EECCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCEECCCCCCCC
DNFRGERGRRGSLLPRGLQRVTRIDINGDNGSTEES
HHHCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]