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The map label for this gene is murC

Identifier: 209696051

GI number: 209696051

Start: 2859781

End: 2861244

Strand: Reverse

Name: murC

Synonym: VSAL_I2643

Alternate gene names: 209696051

Gene position: 2861244-2859781 (Counterclockwise)

Preceding gene: 209696052

Following gene: 209696050

Centisome position: 86.05

GC content: 40.71

Gene sequence:

>1464_bases
ATGACAACAGAACAGAAACTACAATTAGCTGAAATTAGAACGATGATCCCTGAAATGCGCCGTGTTGAATGCATCCACTT
TGTTGGAATTGGCGGTGCGGGTATGAGTGGGATTGCGGAAGTTTTATTAAATGAGGGCTACCATATTAGTGGCTCTGATG
TTGCAGAAAATAGTGTCACTGTTCGTTTAGCTGAAAAGGGTGCTGATATATTTTTTGGGCATCACGCAAGTAATGTAGAA
AAAGCGAGTGTGGTGGTTGTATCAACGGCGATAGATCAAGCTAACCCTGAAATCGTAGCAGCAAAAGAAAATCGTATCCC
TGTGATACGTCGCGCTGAAATGCTTGCTGAATTAATGCGTTATAGACATGGGATCGCGGTTGCGGGGACTCATGGTAAAA
CAACAACAACGGCATTAACCACTCAAATTTATTCAGAAGCAGGTTTAGATCCTACTTTTGTTAATGGCGGCTTGGTTAAG
AATGCTGGAACGAATGCCCGTTTAGGTTCAAGTCGTTTTCTTATTGCTGAAGCCGATGAAAGTGATGCCTCATTTTTACA
CTTGCAGCCAATGGTAAGTATTGTCACTAACATTGAAGCCGATCATATGGATACTTATGGCGGTGACTTTGAAGTGTTAA
AACAAACTTTTATTGATTTTCTTCATAACCTGCCATTTTATGGTCAAGCTGTCATGTGTATTGATGATGATGTGGTAAGA
GAGTTATTACCGCGCGTTAGTCGCCAAGTTATTACGTACGGTTTTTCCGATGATGCGGATGTACGTTTAATTAATTATCG
TCAAGAAGGTCAAAAAAGCTTTTTCACGGTACAAAGAAAAGATCGTACAGATTTAGATATTGTCCTTAATATTCCGGGTA
AACATAATGCATTGAATGCAACAGCAGCCATTGCTGTTGCTACTGAAGAAGACGTTGAAGATAGCGCGATTCTTTCCGCA
TTACTCAATTTTGAAGGTGCTGGGCGTCGATTTGATCAGTTAGGTGAGTTTGAAACGGGCAATGGACACGCGATGCTTGT
CGATGATTACGGTCATCACCCTACAGAAGTCGATGTTACGATTAAAGCGGCACGTGCAGGCTGGGAAGATAAACGTTTAG
TTATGATATTCCAACCTCACCGTTATAGCCGAACGCGTGATTTGTATGATGATTTTGCTAACGTTTTAGATAATGTTGAT
GTACTTATTATGCTTGATGTTTATTCAGCGGGTGAAAAACCCATTGCAGGTGCTGATGGCCGAGCGTTGTGTCGTACGAT
TCGAGCTCGTGGTAAATTAGATCCAATATTTGTTCCAACTATTGATGCATTACCCTCTGTTTTGGCTAACATCATTCAAA
ATAATGATTTAGTGCTGACACAAGGGGCTGGTGATGTTGGTAAATTAGCAAAACAACTCGCTTCATTGGAATTAAATATC
CAAGCAATGAAAGAGTTAGGTTAA

Upstream 100 bases:

>100_bases
AATGGCATGTAATGCCCGTAATGCAGCTATTATTGATGCAGATGTACGTGTTGCCACTGCGATTAAAAGCCTCGCTAAAT
AAAAGAATTGAGATTAAAAA

Downstream 100 bases:

>100_bases
ATATTGTTTAAATAGTTAGAACAACTAAGAAAAAAACGCATAATGGGATAGAATCCTCATTGTATTAATAATATGCTATC
AAACATTGGATAGAGGGTTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVTVRLAEKGADIFFGHHASNVE
KASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVK
NAGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVR
ELLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDSAILSA
LLNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVTIKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVD
VLIMLDVYSAGEKPIAGADGRALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNI
QAMKELG

Sequences:

>Translated_487_residues
MTTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVTVRLAEKGADIFFGHHASNVE
KASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVK
NAGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVR
ELLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDSAILSA
LLNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVTIKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVD
VLIMLDVYSAGEKPIAGADGRALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNI
QAMKELG
>Mature_486_residues
TTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVTVRLAEKGADIFFGHHASNVEK
ASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKN
AGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVRE
LLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDSAILSAL
LNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVTIKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVDV
LIMLDVYSAGEKPIAGADGRALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNIQ
AMKELG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=483, Percent_Identity=69.9792960662526, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=400, Percent_Identity=28.5, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ALISL (B6ELH4)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263981.1
- GeneID:   6988571
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2643
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53280; Mature: 53149

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVT
CCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCEE
VRLAEKGADIFFGHHASNVEKASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMR
EEEECCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKNAGTNARLGSSRFLIAEADE
HHCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHH
ELLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNA
HHHHHHHHHEEEECCCCCCCEEEEEEHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
TAAIAVATEEDVEDSAILSALLNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVT
EEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVDVLIMLDVYSAGEKPIAGADG
EEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
RALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNI
HHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCC
QAMKELG
HHHHHCC
>Mature Secondary Structure 
TTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVT
CCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCEE
VRLAEKGADIFFGHHASNVEKASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMR
EEEECCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKNAGTNARLGSSRFLIAEADE
HHCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHH
ELLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNA
HHHHHHHHHEEEECCCCCCCEEEEEEHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
TAAIAVATEEDVEDSAILSALLNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVT
EEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVDVLIMLDVYSAGEKPIAGADG
EEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
RALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNI
HHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCC
QAMKELG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA