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The map label for this gene is flaL [H]

Identifier: 209695742

GI number: 209695742

Start: 2483783

End: 2484826

Strand: Reverse

Name: flaL [H]

Synonym: VSAL_I2311

Alternate gene names: 209695742

Gene position: 2484826-2483783 (Counterclockwise)

Preceding gene: 209695743

Following gene: 209695741

Centisome position: 74.73

GC content: 42.43

Gene sequence:

>1044_bases
ATGCAAGGTAATATTGAGAGTGAATCTTACTCACTTCTTGGTTCAGTAGAAGAGCAAAATACACGATATAAGCAAGTGCT
TGATGTTATGCCTGCTGGGGTGATCCTATTGGATACCCAAGGTATTGTGTGTGAAGTAAACCCCGAAGCGGTTAAGTTAT
TAGGTCCGCCATTATTAGGTGAACGTTGGTTTGAAGTAATTCAACGATCGTTTGATCCTAAAGAAGATGATGGTCACGAG
ATCTCTTTACGCAGTGGACGAAAAGTACGTTTAGCTATTTCTGCGTCTGCGACGGGCCAGTTGATTCTTATTACGGATTT
GACGGAAACACGGCTATTACAATCTCGCGTCAGTGATCTACAGCGTTTATCTTCATTAGGTAAAATGGTGGCTTCTTTGG
CTCACCAAGTAAGAACGCCACTATCAAGCGCCATGCTATATGCCTCTAATCTAGGCTCTCCAAATCTCCCTGCCGCGACA
CACAAACGATTTCAAACCAAACTTGTTGATAGACTTCATGATCTAGAAAAACAAGTGAATGACATGCTGTTGTTTGCCAA
AGGCGGCGACAATAAAGTGGTTAAACCTTTTTCAATTGCAGAGCTTGTTGCCGAATATCGCCCAATGGTAGAAACCGCAT
TGCAATCGAATAACGTTGATTACTACTTAGAAGTTGAGCATGAACATACAACGATGATGGGAAATGCAAACGCCATTGCA
AGTGCCATCAGTAACCTCATTATGAATGCGATTCAGGTCATTGGAAAAGGCGCTCAAATTGATGTCTTTTTTCGACCCGT
TAACGGTTTCTTAAAAATATCGGTGCAAGACAACGGCCCCGGTATTCCGTTTGAGCTACAAGATAAAATTATGGAACCCT
TTTTTACAACACGGTCACAAGGCACCGGTCTTGGTCTGGCGGTTGTTCAAATGGTTTGCCGAGCACACAAAGGGCAATTA
GATTTGTATTCAAAACCAGATGATGGTGCGTGCTTCACCATGTCAATTCCTCTTACCACTACTCAAACTGATTCTGGAGA
ATAA

Upstream 100 bases:

>100_bases
TGTCAATAAGTTTTCAATTTAACTTGTTGATAAGTAACAGTAAAAGGGCTGGCATGTAAAATGCATTAGCCCTTTTGTTG
TTTTGGCGGGAAATAAATAT

Downstream 100 bases:

>100_bases
CAATGGCTCAAAGCAAAGTATTAATTGTTGAAGATGATGAAGGTCTACGCGAAGCATTGATCGACACATTGGAATTGGCA
GGGTATGAGTGGGTAGAGGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQGNIESESYSLLGSVEEQNTRYKQVLDVMPAGVILLDTQGIVCEVNPEAVKLLGPPLLGERWFEVIQRSFDPKEDDGHE
ISLRSGRKVRLAISASATGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFSIAELVAEYRPMVETALQSNNVDYYLEVEHEHTTMMGNANAIA
SAISNLIMNAIQVIGKGAQIDVFFRPVNGFLKISVQDNGPGIPFELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
DLYSKPDDGACFTMSIPLTTTQTDSGE

Sequences:

>Translated_347_residues
MQGNIESESYSLLGSVEEQNTRYKQVLDVMPAGVILLDTQGIVCEVNPEAVKLLGPPLLGERWFEVIQRSFDPKEDDGHE
ISLRSGRKVRLAISASATGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFSIAELVAEYRPMVETALQSNNVDYYLEVEHEHTTMMGNANAIA
SAISNLIMNAIQVIGKGAQIDVFFRPVNGFLKISVQDNGPGIPFELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
DLYSKPDDGACFTMSIPLTTTQTDSGE
>Mature_347_residues
MQGNIESESYSLLGSVEEQNTRYKQVLDVMPAGVILLDTQGIVCEVNPEAVKLLGPPLLGERWFEVIQRSFDPKEDDGHE
ISLRSGRKVRLAISASATGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFSIAELVAEYRPMVETALQSNNVDYYLEVEHEHTTMMGNANAIA
SAISNLIMNAIQVIGKGAQIDVFFRPVNGFLKISVQDNGPGIPFELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
DLYSKPDDGACFTMSIPLTTTQTDSGE

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=359, Percent_Identity=27.5766016713092, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=30.9236947791165, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=26.1802575107296, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786600, Length=339, Percent_Identity=23.598820058997, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790300, Length=348, Percent_Identity=24.7126436781609, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=29.3859649122807, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=29.004329004329, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=24.7967479674797, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=25.8064516129032, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38091; Mature: 38091

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGNIESESYSLLGSVEEQNTRYKQVLDVMPAGVILLDTQGIVCEVNPEAVKLLGPPLLG
CCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHCCCCCHH
ERWFEVIQRSFDPKEDDGHEISLRSGRKVRLAISASATGQLILITDLTETRLLQSRVSDL
HHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHH
QRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAATHKRFQTKLVDRLHDLEKQVN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DMLLFAKGGDNKVVKPFSIAELVAEYRPMVETALQSNNVDYYLEVEHEHTTMMGNANAIA
HEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHH
SAISNLIMNAIQVIGKGAQIDVFFRPVNGFLKISVQDNGPGIPFELQDKIMEPFFTTRSQ
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
GTGLGLAVVQMVCRAHKGQLDLYSKPDDGACFTMSIPLTTTQTDSGE
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECEEECCCCCCC
>Mature Secondary Structure
MQGNIESESYSLLGSVEEQNTRYKQVLDVMPAGVILLDTQGIVCEVNPEAVKLLGPPLLG
CCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHCCCCCHH
ERWFEVIQRSFDPKEDDGHEISLRSGRKVRLAISASATGQLILITDLTETRLLQSRVSDL
HHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHH
QRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAATHKRFQTKLVDRLHDLEKQVN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DMLLFAKGGDNKVVKPFSIAELVAEYRPMVETALQSNNVDYYLEVEHEHTTMMGNANAIA
HEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHH
SAISNLIMNAIQVIGKGAQIDVFFRPVNGFLKISVQDNGPGIPFELQDKIMEPFFTTRSQ
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
GTGLGLAVVQMVCRAHKGQLDLYSKPDDGACFTMSIPLTTTQTDSGE
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]