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The map label for this gene is ycbL [H]

Identifier: 209695259

GI number: 209695259

Start: 1899190

End: 1899843

Strand: Reverse

Name: ycbL [H]

Synonym: VSAL_I1782

Alternate gene names: 209695259

Gene position: 1899843-1899190 (Counterclockwise)

Preceding gene: 209695260

Following gene: 209695258

Centisome position: 57.14

GC content: 40.37

Gene sequence:

>654_bases
ATGAGCTTACAATATCAAATTATTCCGGTTACTGCTTATGAGCAAAACTGCTCTATTGTTTGGTGTGATGAAACAATGAA
AGGAGTGGTGGTTGATCCTGGTGGTGATGTGGATCTTCTAAAACAAGCGATAGACGCATTGAATATCGATGTGGTTAGTT
TGGTACTAACTCATGGTCACTTAGACCACGTTGGTGGCACAGAGCCTTTAGCTGCATTAACGGGTGCTCCAATTATTGGT
CCGCATAAAGAAGATGAATTTTGGTTACAAGGGCTTCCAAGTCAAAGTCAACGATTTGGTTTTCCACATACCGATGCGTT
TGAACCCAATCAATGGTTAGAGGAAGGCGATATTGTTGAATTTGGTAATCAAGCACTGCATGTGCTGCATACTCCGGGTC
ATACTCCCGGTCATGTAATACTGTTTAATCAAGAAGCTAAGATGGCATTTGTTGGTGATGTATTGTTTAAAGGTGCGATT
GGTCGTTCTGATTTCCCTAAAGGTGATTACGAAACATTAATTGCATCAATTAAAACAAAACTGTGGCCTTTAGGTAATGA
GATGAAATTTGTACCGGGACATGGACCTGAGTCTACGTTTGGTTATGAACGTAAAACAAATCCATTTGTAGCGGATGAAT
TGCCTCTTTGGTAA

Upstream 100 bases:

>100_bases
GGGTGATGTGGGATAATCATTGGAGTAAAATTCTGGTCTGAATTCCACTTAAATAATAGTCATGTTATTCTTAGGATAAT
TCATTTAAGAAGAGATAAAC

Downstream 100 bases:

>100_bases
GTATTTTGGCAAAAGTGCCGCACTTTTCGCCATACAGTGCAGCCATGCCTATAAATATTGCGCGTTTTTTGGTATAAAAC
GCGCTTCGCCAATTCCGATA

Product: Metallo-beta-lactamase

Products: glutathione; 2-hydroxy carboxylate

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSLQYQIIPVTAYEQNCSIVWCDETMKGVVVDPGGDVDLLKQAIDALNIDVVSLVLTHGHLDHVGGTEPLAALTGAPIIG
PHKEDEFWLQGLPSQSQRFGFPHTDAFEPNQWLEEGDIVEFGNQALHVLHTPGHTPGHVILFNQEAKMAFVGDVLFKGAI
GRSDFPKGDYETLIASIKTKLWPLGNEMKFVPGHGPESTFGYERKTNPFVADELPLW

Sequences:

>Translated_217_residues
MSLQYQIIPVTAYEQNCSIVWCDETMKGVVVDPGGDVDLLKQAIDALNIDVVSLVLTHGHLDHVGGTEPLAALTGAPIIG
PHKEDEFWLQGLPSQSQRFGFPHTDAFEPNQWLEEGDIVEFGNQALHVLHTPGHTPGHVILFNQEAKMAFVGDVLFKGAI
GRSDFPKGDYETLIASIKTKLWPLGNEMKFVPGHGPESTFGYERKTNPFVADELPLW
>Mature_216_residues
SLQYQIIPVTAYEQNCSIVWCDETMKGVVVDPGGDVDLLKQAIDALNIDVVSLVLTHGHLDHVGGTEPLAALTGAPIIGP
HKEDEFWLQGLPSQSQRFGFPHTDAFEPNQWLEEGDIVEFGNQALHVLHTPGHTPGHVILFNQEAKMAFVGDVLFKGAIG
RSDFPKGDYETLIASIKTKLWPLGNEMKFVPGHGPESTFGYERKTNPFVADELPLW

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=194, Percent_Identity=30.9278350515464, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1787158, Length=215, Percent_Identity=55.8139534883721, Blast_Score=273, Evalue=4e-75,
Organism=Drosophila melanogaster, GI221330176, Length=198, Percent_Identity=24.7474747474747, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: 3.1.2.6

Molecular weight: Translated: 23911; Mature: 23780

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQYQIIPVTAYEQNCSIVWCDETMKGVVVDPGGDVDLLKQAIDALNIDVVSLVLTHGH
CCCEEEEEEEEEECCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCC
LDHVGGTEPLAALTGAPIIGPHKEDEFWLQGLPSQSQRFGFPHTDAFEPNQWLEEGDIVE
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCCCCHHHHCCCCEEE
FGNQALHVLHTPGHTPGHVILFNQEAKMAFVGDVLFKGAIGRSDFPKGDYETLIASIKTK
ECCCEEEEEECCCCCCCEEEEECCCCCEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LWPLGNEMKFVPGHGPESTFGYERKTNPFVADELPLW
HCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLQYQIIPVTAYEQNCSIVWCDETMKGVVVDPGGDVDLLKQAIDALNIDVVSLVLTHGH
CCEEEEEEEEEECCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCC
LDHVGGTEPLAALTGAPIIGPHKEDEFWLQGLPSQSQRFGFPHTDAFEPNQWLEEGDIVE
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCCCCHHHHCCCCEEE
FGNQALHVLHTPGHTPGHVILFNQEAKMAFVGDVLFKGAIGRSDFPKGDYETLIASIKTK
ECCCEEEEEECCCCCCCEEEEECCCCCEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LWPLGNEMKFVPGHGPESTFGYERKTNPFVADELPLW
HCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-(2-hydroxyacyl)glutathione; H2O

Specific reaction: S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]