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The map label for this gene is gltP [H]

Identifier: 209694856

GI number: 209694856

Start: 1435503

End: 1436786

Strand: Reverse

Name: gltP [H]

Synonym: VSAL_I1325

Alternate gene names: 209694856

Gene position: 1436786-1435503 (Counterclockwise)

Preceding gene: 209694860

Following gene: 209694855

Centisome position: 43.21

GC content: 41.51

Gene sequence:

>1284_bases
ATGAAAAAATCACTTTCAAGTAGAATTTTTATAGGTTTATTCGCTGGCCTATTAATTGGTACCGCGATTCAATACCTGTT
TAATGGGGTTGCGTTTTTTGATTCGTTCCTACTAGGAGCAGCAGAAGGCGTTGGTGGGATGTTTGTTTCACTCATCAAAT
TACTTGTTGTTCCTCTCGTTTATGTCTCTATTGTTTGCGGTATCGTTGAACTAAAAGACATTGCTTCATTTGGTCGCCTT
GGTGGGAAAACTTTTGCTCTTTACCTTATTAACACCATCATTGCGATAGCCGCAGCATTAACCGTCGGTATGATCTTTGC
CCCTGGTGCAGATGCAAACTTAGCAGGAACCGTTGTCGTCGGCTCTGTTGAGCTAAAAGCAACGGAAACCCCGGACATCT
TCTCACTCATTACGAATATCGTTCCTAGCAACCCTGTAGAGGCATTTGCTAGCGGTAATATGCTACAAATCATCTTTATG
GCAATTTTAACGGGTCTTGCCATTCAAGCCCTTGATCATCGTGGGGGTCCTGCGATTAAAACGTTTAAAGTTGCCAATGA
AATCATGATGAAGCTAATTAGCTTAGTGATGAGCCTCACTCCTTATGGTGTGTTTGCTCTGATGATTCAATTAGGTGCGA
CGTTAGATGCAAATACCTTAATGTCAGTTGCAGGTTACGTGGCTCTTGTTGTTTCGATGCTTGTTTTCTGGATTTTTGTT
TTTTATCCAATCATGGTTGGTTTATCAACTGGGATTTCACCTAAAACATTTTTACGTGCAGTACGTGAGCAAATTTTATT
CTCACTTTCAACAGCAAGTTCAAATGCGACCATCCCTGTAACGATGCGAACATTAACTGAAAAGTTAAACGTATCTAAAT
CTGTGGCCGGTTTTGGTGTTCCATTAGGCGCAACCATGAATATGTCTGGTGTCTCTATTTATATTGCTCTTGCCGCTATC
TTTGTTGCTAATGCTTTTGGTCAACCTATCGACTCAGCGGATCTATTTACATTAGGCTTCACTATTCTATTACTTTCCAT
TGGTGCTGGTGGTGTTCCGGGTGGTGGTGTTGTCATGGTCGGCGTTATTTTACACCAACTTGGCCTTCCGCCTGAAGGTC
TTGCTATTGTGGCCGCGGTTGACCGTATTAACGATATGTTCTGTACTTCGTCTAATGTTGTTGGTGATACCGCAGTAAAT
ACCATTGTTGCCAAATCAGAAGGTGAAATAGGTAAAGCAGAATCAACCACTGATGAAGTATTTACTGAAAAAGTAAACGG
CTAG

Upstream 100 bases:

>100_bases
TTAACGATATGTAAACATCCTGTTGATTTCTCAATTAATAGAGAAACATTACAAGGACTCACCTATTAGTGAGCACAATA
TTCTGGAGAAAAAGTACATA

Downstream 100 bases:

>100_bases
TTCTATATTTAGTATAAATATCAATATAAAGAGAGAGCTCGTTATGCTCTCTCTTTATATTCAGACATAAAGCATTTATA
ATGTGACTACATTTTTTTTA

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKKSLSSRIFIGLFAGLLIGTAIQYLFNGVAFFDSFLLGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTVVVGSVELKATETPDIFSLITNIVPSNPVEAFASGNMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLTPYGVFALMIQLGATLDANTLMSVAGYVALVVSMLVFWIFV
FYPIMVGLSTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPIDSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIGKAESTTDEVFTEKVNG

Sequences:

>Translated_427_residues
MKKSLSSRIFIGLFAGLLIGTAIQYLFNGVAFFDSFLLGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTVVVGSVELKATETPDIFSLITNIVPSNPVEAFASGNMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLTPYGVFALMIQLGATLDANTLMSVAGYVALVVSMLVFWIFV
FYPIMVGLSTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPIDSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIGKAESTTDEVFTEKVNG
>Mature_427_residues
MKKSLSSRIFIGLFAGLLIGTAIQYLFNGVAFFDSFLLGAAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIASFGRL
GGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTVVVGSVELKATETPDIFSLITNIVPSNPVEAFASGNMLQIIFM
AILTGLAIQALDHRGGPAIKTFKVANEIMMKLISLVMSLTPYGVFALMIQLGATLDANTLMSVAGYVALVVSMLVFWIFV
FYPIMVGLSTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALAAI
FVANAFGQPIDSADLFTLGFTILLLSIGAGGVPGGGVVMVGVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVN
TIVAKSEGEIGKAESTTDEVFTEKVNG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=28.6764705882353, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI194239697, Length=425, Percent_Identity=27.7647058823529, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=29.75, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4827012, Length=280, Percent_Identity=30.7142857142857, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI169790839, Length=414, Percent_Identity=26.3285024154589, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=31.331592689295, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI66773030, Length=268, Percent_Identity=30.2238805970149, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223468564, Length=256, Percent_Identity=31.640625, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI223468566, Length=256, Percent_Identity=31.640625, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI262359914, Length=373, Percent_Identity=25.7372654155496, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI301601644, Length=140, Percent_Identity=36.4285714285714, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=32.0843091334895, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1789947, Length=429, Percent_Identity=28.4382284382284, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788024, Length=431, Percent_Identity=28.0742459396752, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789473, Length=228, Percent_Identity=30.2631578947368, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=399, Percent_Identity=28.8220551378446, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=399, Percent_Identity=28.8220551378446, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=420, Percent_Identity=28.5714285714286, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=422, Percent_Identity=26.5402843601896, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=393, Percent_Identity=28.498727735369, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=27.2511848341232, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=414, Percent_Identity=24.6376811594203, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=26.1682242990654, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=26.1682242990654, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=26.1682242990654, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281360481, Length=315, Percent_Identity=26.031746031746, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281360483, Length=315, Percent_Identity=26.031746031746, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137666, Length=315, Percent_Identity=26.031746031746, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44458; Mature: 44458

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLSSRIFIGLFAGLLIGTAIQYLFNGVAFFDSFLLGAAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIASFGRLGGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTVVV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GSVELKATETPDIFSLITNIVPSNPVEAFASGNMLQIIFMAILTGLAIQALDHRGGPAIK
EEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
TFKVANEIMMKLISLVMSLTPYGVFALMIQLGATLDANTLMSVAGYVALVVSMLVFWIFV
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYPIMVGLSTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHHHCCCC
PLGATMNMSGVSIYIALAAIFVANAFGQPIDSADLFTLGFTILLLSIGAGGVPGGGVVMV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIGKAESTTDEV
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHH
FTEKVNG
HHHHCCC
>Mature Secondary Structure
MKKSLSSRIFIGLFAGLLIGTAIQYLFNGVAFFDSFLLGAAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIASFGRLGGKTFALYLINTIIAIAAALTVGMIFAPGADANLAGTVVV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GSVELKATETPDIFSLITNIVPSNPVEAFASGNMLQIIFMAILTGLAIQALDHRGGPAIK
EEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
TFKVANEIMMKLISLVMSLTPYGVFALMIQLGATLDANTLMSVAGYVALVVSMLVFWIFV
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYPIMVGLSTGISPKTFLRAVREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHHHCCCC
PLGATMNMSGVSIYIALAAIFVANAFGQPIDSADLFTLGFTILLLSIGAGGVPGGGVVMV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVILHQLGLPPEGLAIVAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIGKAESTTDEV
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHH
FTEKVNG
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]