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The map label for this gene is hisC

Identifier: 209694685

GI number: 209694685

Start: 1238690

End: 1239730

Strand: Direct

Name: hisC

Synonym: VSAL_I1135

Alternate gene names: 209694685

Gene position: 1238690-1239730 (Clockwise)

Preceding gene: 209694684

Following gene: 209694686

Centisome position: 37.25

GC content: 40.06

Gene sequence:

>1041_bases
ATGGAAAAATTAGCTCGTAAACAAGTTCAAGCCTTGACGCCGTATCTATCGGCTCGTCGTATTGGTGGCAGTGGTGATGT
TTGGCTTAATGCTAATGAGTCCCCATTTGATAATGAGTATAACGTAAATTTTACTCGTCTAAATCGTTACAGTGAGTGTC
AGCCTCCAGAATTGATTAATGCTTATGCTGCTTATGCAAAAGTAACAGCAGAGCAGGTGCTGACTTCTCGAGGTGCTGAC
GAGGGTATTGAGTTATTAATTCGTGCTTTTTGTGAGCCAAATGAAGACGCGATTTTATATTGTCCACCAACCTATGGTAT
GTATTCCATCAGTGCTGAGACGATTGGGGTTGAGACTAAAACAATACCTTTAACATCAGAATGGCAGCTTGATCTTCCAA
GCATTGAACGCAATTTAGACAATGTAAAATTGGTCTTTGTATGTAGTCCAAATAACCCAACAGGTAATGTGATTAACCGT
AAGGATATTTTGTCTTTATTAGAGATGACAAAAGATCGTGCGATTGTGGTGATGGATGAAGCTTATATTGATTTTTGTAT
GGAAGTGTCAACCGTTGATTTATTGGCGACATACCCCAATTTAGCCATTTTACGAACGCTATCCAAAGCATTTGCCTTAG
CGGGATTACGCTGTGGTTTCACTCTTGCAAATAAAGAGTTGATTGATGTGTTATCTAAAGTGATTGCTCCGTACCCTGTT
CCTGTTCCTGTCGCTGACATTGCAACTCAAGCATTATCAGAAGCAGGTTTAGCCCGCATGAAATACCAAATGCTTGATTT
AAGCGCCAACCGTGCTTATTTGCACGCAGGATTAATGGTATTGAATGGAGTTACTGTTCATGAAGGTTGGGGTAACTATT
TATTAGTGCAGTTCTCTGATGGCGATGCAGTGTTTAAAGCAGCATGGGATCACGGCATTATTTTACGTAATTCACCAATT
AAAGATTGTGTGCGTATTAGTGTGGGTAACCGCGAAGAGTGTGAGAAAACATTAGGCTTTATTCGTAACCAATTAATGTG
A

Upstream 100 bases:

>100_bases
TTGTCACAATGGCTGATGCTGAAGGGCTAGATGCACATAAACGTGCCGTGACTATTCGAATTGAAAAATTAGCTAAATTG
AATTAATAGAGACCATAGAT

Downstream 100 bases:

>100_bases
TTTTATCCCCGAAAGCTTAGGAATAAGGCTTGGGGCTTATCAAGAATAAAACAAGAAAAAATTAAAAGGAAGTTCCTGTG
AGCAAACAACAAAAGATTTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYNVNFTRLNRYSECQPPELINAYAAYAKVTAEQVLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSISAETIGVETKTIPLTSEWQLDLPSIERNLDNVKLVFVCSPNNPTGNVINR
KDILSLLEMTKDRAIVVMDEAYIDFCMEVSTVDLLATYPNLAILRTLSKAFALAGLRCGFTLANKELIDVLSKVIAPYPV
PVPVADIATQALSEAGLARMKYQMLDLSANRAYLHAGLMVLNGVTVHEGWGNYLLVQFSDGDAVFKAAWDHGIILRNSPI
KDCVRISVGNREECEKTLGFIRNQLM

Sequences:

>Translated_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYNVNFTRLNRYSECQPPELINAYAAYAKVTAEQVLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSISAETIGVETKTIPLTSEWQLDLPSIERNLDNVKLVFVCSPNNPTGNVINR
KDILSLLEMTKDRAIVVMDEAYIDFCMEVSTVDLLATYPNLAILRTLSKAFALAGLRCGFTLANKELIDVLSKVIAPYPV
PVPVADIATQALSEAGLARMKYQMLDLSANRAYLHAGLMVLNGVTVHEGWGNYLLVQFSDGDAVFKAAWDHGIILRNSPI
KDCVRISVGNREECEKTLGFIRNQLM
>Mature_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYNVNFTRLNRYSECQPPELINAYAAYAKVTAEQVLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSISAETIGVETKTIPLTSEWQLDLPSIERNLDNVKLVFVCSPNNPTGNVINR
KDILSLLEMTKDRAIVVMDEAYIDFCMEVSTVDLLATYPNLAILRTLSKAFALAGLRCGFTLANKELIDVLSKVIAPYPV
PVPVADIATQALSEAGLARMKYQMLDLSANRAYLHAGLMVLNGVTVHEGWGNYLLVQFSDGDAVFKAAWDHGIILRNSPI
KDCVRISVGNREECEKTLGFIRNQLM

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=346, Percent_Identity=59.5375722543353, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=32.2751322751323, Blast_Score=169, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_ALISL (B6EJ89)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262613.1
- ProteinModelPortal:   B6EJ89
- GeneID:   6988663
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1135
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK04635
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38396; Mature: 38396

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYNVNFTRLNRYSECQPPELIN
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
AYAAYAKVTAEQVLTSRGADEGIELLIRAFCEPNEDAILYCPPTYGMYSISAETIGVETK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCEECCEEE
TIPLTSEWQLDLPSIERNLDNVKLVFVCSPNNPTGNVINRKDILSLLEMTKDRAIVVMDE
EECCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEH
AYIDFCMEVSTVDLLATYPNLAILRTLSKAFALAGLRCGFTLANKELIDVLSKVIAPYPV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCCC
PVPVADIATQALSEAGLARMKYQMLDLSANRAYLHAGLMVLNGVTVHEGWGNYLLVQFSD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEECC
GDAVFKAAWDHGIILRNSPIKDCVRISVGNREECEKTLGFIRNQLM
CCEEEEEECCCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYNVNFTRLNRYSECQPPELIN
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
AYAAYAKVTAEQVLTSRGADEGIELLIRAFCEPNEDAILYCPPTYGMYSISAETIGVETK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCEECCEEE
TIPLTSEWQLDLPSIERNLDNVKLVFVCSPNNPTGNVINRKDILSLLEMTKDRAIVVMDE
EECCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEH
AYIDFCMEVSTVDLLATYPNLAILRTLSKAFALAGLRCGFTLANKELIDVLSKVIAPYPV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCCC
PVPVADIATQALSEAGLARMKYQMLDLSANRAYLHAGLMVLNGVTVHEGWGNYLLVQFSD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEECC
GDAVFKAAWDHGIILRNSPIKDCVRISVGNREECEKTLGFIRNQLM
CCEEEEEECCCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA