Click here to switch to the map view.

The map label for this gene is holA [H]

Identifier: 209694551

GI number: 209694551

Start: 1090734

End: 1091771

Strand: Reverse

Name: holA [H]

Synonym: VSAL_I0988

Alternate gene names: 209694551

Gene position: 1091771-1090734 (Counterclockwise)

Preceding gene: 209694552

Following gene: 209694550

Centisome position: 32.83

GC content: 36.99

Gene sequence:

>1038_bases
ATGCGAGTATTCCCTGAACAGCTAGTACAAAACTTAGAACGTGGTTTACGTCAAAATTACCTATTATTTGGTAATGAGCC
ACTTCTAAAACAAGAATGCCTCGATCAAATCCGTAAGCACAGTTTTCAACAGGGTTTTGAAGAAAAGCATCAATTTACGT
TAGACAAACAATTGGACTGGAACCTGATCTTCGATTGCACTCAAGCATTAAGTCTATTTTCATCAAGACAAATTATCGAA
TTAACCGTTTCAGATACAGGTTTAACTGCGGCTCACACCAGTAAAATAAAAGAACTCGTCCCTATGTTACACGACGATAT
TTTGTTGATATTTCAAGGCCCAAGAGTCAATAAAAGCCAAGAAAGTACCCAATGGTTTAAAGCATTAACACAACAAGGGT
TATTTATTCCTTGTAACACCCCTGATAACCAACAATTACCTCGTTTTATTCAACAACGTTGTAAATTATTAAAATTAAAA
CCTGACGCAGAAGCAGTACAAATGCTAGCGCAATGGCATGAAGGTAACCTACTTGCACTTGCTCAAAGTTTAGACAAACT
GTCTTTATTATACCCCGATGGGTTACTGACTCTTATTAGAATAGAAGAAGCGTTAAACCGTAATAATCACTTCACTCCTT
TCCAGTTAATGGATGCTTTATTATTTGGTCAAGCAAAGCGTGCACAACGAATCCTTCGTCAATTAGAAGGTGAAAGTGTT
GAAGTTGTGATTCTCTTACGTACGATCCAAAAAGAAGTGTTCTTATTGCTCTCATTTCAACAAGCAATCAGCCAAGGTGA
AGCAATGTTTACTGTTTTTGATCGTTATAAGGTATGGCAAAACCGTCGTTCATTGTATCAAGCAGCATTGCAACGCTTAT
CAATGACACAAATTCAAGCATTAATAAAATCATTAGCTCAGCTTGAAGTTGCCGTTAAAACCGATTTTGATACCAACTGT
TGGCCACAACTTAGCCAGTTAAGCTTAGATATCTGTAATATTCACATTTCAGTGACACCTCCACCATCTCATTCATAG

Upstream 100 bases:

>100_bases
ATACTGATATTATTAGCAACAAAGACGAAACAGAAACTAAAGTAACAACAAAAGAGATGGCTCAAAGTATGGCTACCTCT
ACAGATAATAAAAAATAATC

Downstream 100 bases:

>100_bases
ACGTTCACTGATATACTTCCTTATAAATAATCGATCCTAGGTGATACTTTGCAAGATAAAGAACTGCACGACTTTCTATT
CAATCATGTTGATGACATGA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRVFPEQLVQNLERGLRQNYLLFGNEPLLKQECLDQIRKHSFQQGFEEKHQFTLDKQLDWNLIFDCTQALSLFSSRQIIE
LTVSDTGLTAAHTSKIKELVPMLHDDILLIFQGPRVNKSQESTQWFKALTQQGLFIPCNTPDNQQLPRFIQQRCKLLKLK
PDAEAVQMLAQWHEGNLLALAQSLDKLSLLYPDGLLTLIRIEEALNRNNHFTPFQLMDALLFGQAKRAQRILRQLEGESV
EVVILLRTIQKEVFLLLSFQQAISQGEAMFTVFDRYKVWQNRRSLYQAALQRLSMTQIQALIKSLAQLEVAVKTDFDTNC
WPQLSQLSLDICNIHISVTPPPSHS

Sequences:

>Translated_345_residues
MRVFPEQLVQNLERGLRQNYLLFGNEPLLKQECLDQIRKHSFQQGFEEKHQFTLDKQLDWNLIFDCTQALSLFSSRQIIE
LTVSDTGLTAAHTSKIKELVPMLHDDILLIFQGPRVNKSQESTQWFKALTQQGLFIPCNTPDNQQLPRFIQQRCKLLKLK
PDAEAVQMLAQWHEGNLLALAQSLDKLSLLYPDGLLTLIRIEEALNRNNHFTPFQLMDALLFGQAKRAQRILRQLEGESV
EVVILLRTIQKEVFLLLSFQQAISQGEAMFTVFDRYKVWQNRRSLYQAALQRLSMTQIQALIKSLAQLEVAVKTDFDTNC
WPQLSQLSLDICNIHISVTPPPSHS
>Mature_345_residues
MRVFPEQLVQNLERGLRQNYLLFGNEPLLKQECLDQIRKHSFQQGFEEKHQFTLDKQLDWNLIFDCTQALSLFSSRQIIE
LTVSDTGLTAAHTSKIKELVPMLHDDILLIFQGPRVNKSQESTQWFKALTQQGLFIPCNTPDNQQLPRFIQQRCKLLKLK
PDAEAVQMLAQWHEGNLLALAQSLDKLSLLYPDGLLTLIRIEEALNRNNHFTPFQLMDALLFGQAKRAQRILRQLEGESV
EVVILLRTIQKEVFLLLSFQQAISQGEAMFTVFDRYKVWQNRRSLYQAALQRLSMTQIQALIKSLAQLEVAVKTDFDTNC
WPQLSQLSLDICNIHISVTPPPSHS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=333, Percent_Identity=46.8468468468468, Blast_Score=287, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39825; Mature: 39825

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFPEQLVQNLERGLRQNYLLFGNEPLLKQECLDQIRKHSFQQGFEEKHQFTLDKQLDW
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLIFDCTQALSLFSSRQIIELTVSDTGLTAAHTSKIKELVPMLHDDILLIFQGPRVNKSQ
HHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCH
ESTQWFKALTQQGLFIPCNTPDNQQLPRFIQQRCKLLKLKPDAEAVQMLAQWHEGNLLAL
HHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHH
AQSLDKLSLLYPDGLLTLIRIEEALNRNNHFTPFQLMDALLFGQAKRAQRILRQLEGESV
HHHHHHHHEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCE
EVVILLRTIQKEVFLLLSFQQAISQGEAMFTVFDRYKVWQNRRSLYQAALQRLSMTQIQA
EEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSLAQLEVAVKTDFDTNCWPQLSQLSLDICNIHISVTPPPSHS
HHHHHHHHHHHEECCCCCCCCCCHHHCEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MRVFPEQLVQNLERGLRQNYLLFGNEPLLKQECLDQIRKHSFQQGFEEKHQFTLDKQLDW
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLIFDCTQALSLFSSRQIIELTVSDTGLTAAHTSKIKELVPMLHDDILLIFQGPRVNKSQ
HHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCH
ESTQWFKALTQQGLFIPCNTPDNQQLPRFIQQRCKLLKLKPDAEAVQMLAQWHEGNLLAL
HHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHH
AQSLDKLSLLYPDGLLTLIRIEEALNRNNHFTPFQLMDALLFGQAKRAQRILRQLEGESV
HHHHHHHHEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCE
EVVILLRTIQKEVFLLLSFQQAISQGEAMFTVFDRYKVWQNRRSLYQAALQRLSMTQIQA
EEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSLAQLEVAVKTDFDTNCWPQLSQLSLDICNIHISVTPPPSHS
HHHHHHHHHHHEECCCCCCCCCCHHHCEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]