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The map label for this gene is proA [H]

Identifier: 209694541

GI number: 209694541

Start: 1081071

End: 1082312

Strand: Direct

Name: proA [H]

Synonym: VSAL_I0978

Alternate gene names: 209694541

Gene position: 1081071-1082312 (Clockwise)

Preceding gene: 209694540

Following gene: 209694554

Centisome position: 32.51

GC content: 41.79

Gene sequence:

>1242_bases
ATGGGTCAAGCAGCAAAAAATGCAGCGTTTGACTTAGCGGTAGCTCCAACAGCCCAGAAGAACAAAGCATTGGCGATTAT
TGCTGATGAACTTGAAGCGAACAAAGAGGCGATTCTTGCGGCTAATGCAAAAGACATTAGTGCAGCGGTAGAAGCGGGCA
TTTCAGAGGCAATGCAAGATCGTTTATTACTAACAGAAGAGCGTTTAGTTGCTATTGCTAATGACGTTCGTAATGTGATC
AACTTAAATGATCCTGTTGGTAGTGAAATTGACAGTAAAATGCTTGAAAATGGCATGTCACTTTCTCGCCGCCGTGTACC
AATTGGTGTGATTGGTGTGATCTATGAAGCTCGTCCAAATGTAACGATCGATATCGCTTCATTATGTTTAAAAACCGGTA
ATGCGAGTATTCTACGTGGTGGTAAAGAGACGTTCTTCTCTAATATGGAGTTAGTTAAGGTCATTCAAGTTGCTCTTGAA
AAAGCCGGCTTACCAGCTGCATCAGTACAATACATAGAGAAACCAGATCGTGAACTAGTTTCAGAGCTATTACGTCTGGA
TGACTACGTTGATATGATCATTCCACGTGGTGGTGCTGGTTTGCACAAAATGTGTAAAGAAAACAGTTCAATTCCAGTCA
TCATTGGCGGGTTTGGTATTAGCCATGCGTTTGTTGATGACAGTGCTGATTTAGAAAGAGCCTTGTTGGTTGTTGATAAC
TCAAAAGCACAACGCCCATCTGCATGTAATGCACTTGATACACTGTTAGTTCATGAGGCAGTGGCTCCACAATTCTTAGC
ATTATTAGCGAATAAAATGGCAGGTCGTGTTGAATTGGTTGCTGAACCAAAAGCTTATTCGTTACTAAAAGAGTTTAAAA
ACGTGTCATTACGTGAAGCACAAGACGGTGATTTTGATACTGAATGGCTAAGTTACACATTAGGTGTGAAAGTGGTGTCT
GATGTAAATGAAGCAGCGGCTCATATGCAAACACATAACGCGAGTCATTCTGATACTATTTTAACAAATAATATTGAATC
TGCTGAAAAGTTCATTAATACCGCAGGTTCAGCTGCCGTGTATGTGAATGCATCAACACGCTTCACTGATGGGGCTCAGT
TTGGTTTAGGCGCTGAAGTTGCGGTATCAACCCAGAAGCTTCATGCTCGTGGTCCAATGGGCTTAGAAGAGCTGACAAGT
TACAAATGGGTGGGGAAAGCGGATTATCTTATTCGCCCATAA

Upstream 100 bases:

>100_bases
TATTTACGCAGTATTAGGTTATGAATATGGGCCTGTAGCTATCCACCGAGATGATTTAGTACTGATTTAGTAAAGGATAT
TTATTGTGAATTTAACAAAA

Downstream 100 bases:

>100_bases
TCATATTGATTAATGTTTAGTAAAAACAAAAAAGGTTGACGCTAAAACGTCAACCTTTTTTATTATTCAGACCCTAGACC
CTAGACCCTAGACCCTAGAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGQAAKNAAFDLAVAPTAQKNKALAIIADELEANKEAILAANAKDISAAVEAGISEAMQDRLLLTEERLVAIANDVRNVI
NLNDPVGSEIDSKMLENGMSLSRRRVPIGVIGVIYEARPNVTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALE
KAGLPAASVQYIEKPDRELVSELLRLDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDDSADLERALLVVDN
SKAQRPSACNALDTLLVHEAVAPQFLALLANKMAGRVELVAEPKAYSLLKEFKNVSLREAQDGDFDTEWLSYTLGVKVVS
DVNEAAAHMQTHNASHSDTILTNNIESAEKFINTAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTS
YKWVGKADYLIRP

Sequences:

>Translated_413_residues
MGQAAKNAAFDLAVAPTAQKNKALAIIADELEANKEAILAANAKDISAAVEAGISEAMQDRLLLTEERLVAIANDVRNVI
NLNDPVGSEIDSKMLENGMSLSRRRVPIGVIGVIYEARPNVTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALE
KAGLPAASVQYIEKPDRELVSELLRLDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDDSADLERALLVVDN
SKAQRPSACNALDTLLVHEAVAPQFLALLANKMAGRVELVAEPKAYSLLKEFKNVSLREAQDGDFDTEWLSYTLGVKVVS
DVNEAAAHMQTHNASHSDTILTNNIESAEKFINTAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTS
YKWVGKADYLIRP
>Mature_412_residues
GQAAKNAAFDLAVAPTAQKNKALAIIADELEANKEAILAANAKDISAAVEAGISEAMQDRLLLTEERLVAIANDVRNVIN
LNDPVGSEIDSKMLENGMSLSRRRVPIGVIGVIYEARPNVTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALEK
AGLPAASVQYIEKPDRELVSELLRLDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDDSADLERALLVVDNS
KAQRPSACNALDTLLVHEAVAPQFLALLANKMAGRVELVAEPKAYSLLKEFKNVSLREAQDGDFDTEWLSYTLGVKVVSD
VNEAAAHMQTHNASHSDTILTNNIESAEKFINTAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSY
KWVGKADYLIRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=407, Percent_Identity=36.1179361179361, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI62912457, Length=407, Percent_Identity=36.1179361179361, Blast_Score=234, Evalue=9e-62,
Organism=Escherichia coli, GI1786438, Length=412, Percent_Identity=57.5242718446602, Blast_Score=480, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17569967, Length=408, Percent_Identity=35.5392156862745, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17569969, Length=408, Percent_Identity=35.5392156862745, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324899, Length=426, Percent_Identity=35.6807511737089, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44357; Mature: 44226

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQAAKNAAFDLAVAPTAQKNKALAIIADELEANKEAILAANAKDISAAVEAGISEAMQD
CCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
RLLLTEERLVAIANDVRNVINLNDPVGSEIDSKMLENGMSLSRRRVPIGVIGVIYEARPN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCCCEEEEEEEEECCCC
VTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALEKAGLPAASVQYIEKPDRELV
CEEEHHHHHHHCCCHHEECCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHH
SELLRLDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDDSADLERALLVVDN
HHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCEEEECCCCCHHCCCCCCCCCEEEEEEEC
SKAQRPSACNALDTLLVHEAVAPQFLALLANKMAGRVELVAEPKAYSLLKEFKNVSLREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCC
QDGDFDTEWLSYTLGVKVVSDVNEAAAHMQTHNASHSDTILTNNIESAEKFINTAGSAAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCCEEE
YVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKADYLIRP
EEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
GQAAKNAAFDLAVAPTAQKNKALAIIADELEANKEAILAANAKDISAAVEAGISEAMQD
CCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
RLLLTEERLVAIANDVRNVINLNDPVGSEIDSKMLENGMSLSRRRVPIGVIGVIYEARPN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCCCEEEEEEEEECCCC
VTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALEKAGLPAASVQYIEKPDRELV
CEEEHHHHHHHCCCHHEECCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHH
SELLRLDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDDSADLERALLVVDN
HHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCEEEECCCCCHHCCCCCCCCCEEEEEEEC
SKAQRPSACNALDTLLVHEAVAPQFLALLANKMAGRVELVAEPKAYSLLKEFKNVSLREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCC
QDGDFDTEWLSYTLGVKVVSDVNEAAAHMQTHNASHSDTILTNNIESAEKFINTAGSAAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCCEEE
YVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKADYLIRP
EEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA