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The map label for this gene is adk

Identifier: 209694395

GI number: 209694395

Start: 905084

End: 905731

Strand: Direct

Name: adk

Synonym: VSAL_I0815

Alternate gene names: 209694395

Gene position: 905084-905731 (Clockwise)

Preceding gene: 209694394

Following gene: 209694396

Centisome position: 27.22

GC content: 41.82

Gene sequence:

>648_bases
ATGCGTATCATCCTTTTAGGTGCACCAGGTGCGGGTAAAGGTACTCAAGCTCAGTTCATCATGGATAAATTTGGTATTCC
ACAAATATCTACAGGTGACATGCTACGTGCAGCGATTATTAAAGCGGGCACTGAAATGGGCAAACAAGCGAAATCAGTAA
TTGATGCGGGTCAACTTGTCTCTGATGAGATCATTCTTGGTCTTGTTAAAGAGCGTATTGCTCAAGAAGATTGCGCTAAA
GGTTTCCTATTAGATGGTTTCCCTCGTACGATCCCTCAAGCAGATGGCCTAAAAGAAAATGGCGTATCAATCGATTACGT
TCTTGAGTTTGACGTTGCTGACGAAGTGATTGTTGAGCGTATGTCTGGTCGTCGTGCTCATCTTCCTTCTGGTCGTACTT
ATCATGTTACGTTCAACCCATCTAAGGTTGAAGGTCAAGATGATGTAACTGGCGAACCGCTGGTTATTCGTGAGGATGAT
AAACCAGAAACAGTTCTTGCTCGTTTAGGTGTTTACCATGAGCAAACTGCACCACTGATTGCTTATTACACTAAAGAAGC
AGAAGCAGGTAAAACAGAATATCTTAAATTTGATGGTACTAAATTAGTAGCAGAAGTGAGTGCTGAGATCGAAAAAGTAC
TTTCGTAA

Upstream 100 bases:

>100_bases
AATAAAACTTATACCTAAATTTATAAATTGAAATGCCGTGCGTATTTTTAGTTTGTAAGGTTTGGTATAAATTCCGAAAT
AAATTTTTAAGGGGAAAACA

Downstream 100 bases:

>100_bases
TCTTACCTAAGTCATCATTTATTGTTATATTGAAGGCGGCCTTATTGGTCGCCTTTTTTTATAGACAATAATGGATAATA
ACAGTGAATAATAAAAAAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRIILLGAPGAGKGTQAQFIMDKFGIPQISTGDMLRAAIIKAGTEMGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAK
GFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVTFNPSKVEGQDDVTGEPLVIREDD
KPETVLARLGVYHEQTAPLIAYYTKEAEAGKTEYLKFDGTKLVAEVSAEIEKVLS

Sequences:

>Translated_215_residues
MRIILLGAPGAGKGTQAQFIMDKFGIPQISTGDMLRAAIIKAGTEMGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAK
GFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVTFNPSKVEGQDDVTGEPLVIREDD
KPETVLARLGVYHEQTAPLIAYYTKEAEAGKTEYLKFDGTKLVAEVSAEIEKVLS
>Mature_215_residues
MRIILLGAPGAGKGTQAQFIMDKFGIPQISTGDMLRAAIIKAGTEMGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAK
GFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVTFNPSKVEGQDDVTGEPLVIREDD
KPETVLARLGVYHEQTAPLIAYYTKEAEAGKTEYLKFDGTKLVAEVSAEIEKVLS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=189, Percent_Identity=47.0899470899471, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI7524346, Length=189, Percent_Identity=47.0899470899471, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=45.1612903225806, Blast_Score=170, Evalue=9e-43,
Organism=Homo sapiens, GI310110345, Length=183, Percent_Identity=44.8087431693989, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI53832003, Length=183, Percent_Identity=44.8087431693989, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI8051579, Length=183, Percent_Identity=44.8087431693989, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI53832001, Length=183, Percent_Identity=44.8087431693989, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=31.5217391304348, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=29.6803652968037, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144897, Length=191, Percent_Identity=28.2722513089005, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144899, Length=191, Percent_Identity=28.2722513089005, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.5698924731183, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=72.8971962616822, Blast_Score=327, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17552384, Length=219, Percent_Identity=42.9223744292237, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17537943, Length=212, Percent_Identity=33.9622641509434, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=28.8372093023256, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=190, Percent_Identity=47.3684210526316, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321018, Length=189, Percent_Identity=42.8571428571429, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=31.3829787234043, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=43.2558139534884, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17737899, Length=186, Percent_Identity=47.8494623655914, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24645822, Length=186, Percent_Identity=47.8494623655914, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=28.8372093023256, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=28.8372093023256, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24663208, Length=182, Percent_Identity=30.2197802197802, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17647141, Length=182, Percent_Identity=30.2197802197802, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ALISL (B6EHK0)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262323.1
- GeneID:   6988688
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0815
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23380; Mature: 23380

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMDKFGIPQISTGDMLRAAIIKAGTEMGKQAKSVIDAGQLV
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVER
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHH
MSGRRAHLPSGRTYHVTFNPSKVEGQDDVTGEPLVIREDDKPETVLARLGVYHEQTAPLI
HCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEE
AYYTKEAEAGKTEYLKFDGTKLVAEVSAEIEKVLS
EEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMDKFGIPQISTGDMLRAAIIKAGTEMGKQAKSVIDAGQLV
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVER
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHH
MSGRRAHLPSGRTYHVTFNPSKVEGQDDVTGEPLVIREDDKPETVLARLGVYHEQTAPLI
HCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEE
AYYTKEAEAGKTEYLKFDGTKLVAEVSAEIEKVLS
EEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA