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The map label for this gene is hemH

Identifier: 209694396

GI number: 209694396

Start: 905815

End: 906783

Strand: Direct

Name: hemH

Synonym: VSAL_I0816

Alternate gene names: 209694396

Gene position: 905815-906783 (Clockwise)

Preceding gene: 209694395

Following gene: 209694397

Centisome position: 27.24

GC content: 38.49

Gene sequence:

>969_bases
GTGAATAATAAAAAAGCAGGGGTGCTATTAGTTAACCTAGGTACACCTACGGCGCCAACAGCAGCGGCAGTAAAAACGTT
TTTATCAGAATTCTTACATGATAAGAGAGTTGTTGATATGAACCGTTTTATTTGGTGCCCTTTGCTTCATGGGGTGATTC
TACCGATTAGAGCGCCTAAAGTTGCAAAGCTATACCAGAGTGTTTGGATGGAAGACGATTCACCATTAATGGTTTATTCA
CAACGTCAAGTGAGCGCATTACAAGATCGTCTTTCTCTTCCTGTCGCTTTAGGCATGACTTACGGTCAACCTGCGATTAA
GTCTGGAATTGAGTTATTAGAAGAGCAAGGTTGTGATGAGATAATCATTTTACCGTTATATCCACAATATTCTAGAACAA
CAACGGCGGCTGTTTTTGACCAAATCGGTAAGCAATATAAAACAACATCGGTGTTGCCTAATTTTACGATGGTTCATAAT
TACCACGATCACCCACTTTATATAAAAGCACTTGCAGAGTCGATTCGCCTTTCTTGGAAAGAAAAAGGAAAAGGGGATTA
TGTGTTATGTTCTTATCATGGTATCCCACAGCGTTTCGTTGATAATGGGGATATCTATGCTGAACATTGTATACGTACGA
CAGAATTACTTGCTGAAGAGCTTGGCTTAAACTCAGAACAAATTGGCATGAGTTATCAGTCGCGTTTTGGTCGAGAAGCA
TGGTTGCAACCCTATACTTCTGAAACATTAAAAGAACTGGCGCCAAAAGGGATAAAATCATTAGATATTATTAGCCCTGC
GTTTTCTGTTGATTGTTTAGAAACACTTGAAGAGTTGTCTGAAGAGTGTAAAGAAATTTATATGACAGCAGGTGGTGAAA
AATACACCTTTATTCCTTGTTTAAATGACGATGAATTACATATTGAGATGATGGCAGCTATTGTCAGTAGTAAGATTTCA
CGTAGTTAA

Upstream 100 bases:

>100_bases
AAAAAGTACTTTCGTAATCTTACCTAAGTCATCATTTATTGTTATATTGAAGGCGGCCTTATTGGTCGCCTTTTTTTATA
GACAATAATGGATAATAACA

Downstream 100 bases:

>100_bases
CCTCGTTTTTTAGAAAAAAAAGCGTTTAAAAGGGTTGAAAAATACTAGTCATTGCCCAATTTCTTATTAAAGATTATCTA
CGTGTGTAGTGAGCCTCGAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNNKKAGVLLVNLGTPTAPTAAAVKTFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYQSVWMEDDSPLMVYS
QRQVSALQDRLSLPVALGMTYGQPAIKSGIELLEEQGCDEIIILPLYPQYSRTTTAAVFDQIGKQYKTTSVLPNFTMVHN
YHDHPLYIKALAESIRLSWKEKGKGDYVLCSYHGIPQRFVDNGDIYAEHCIRTTELLAEELGLNSEQIGMSYQSRFGREA
WLQPYTSETLKELAPKGIKSLDIISPAFSVDCLETLEELSEECKEIYMTAGGEKYTFIPCLNDDELHIEMMAAIVSSKIS
RS

Sequences:

>Translated_322_residues
MNNKKAGVLLVNLGTPTAPTAAAVKTFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYQSVWMEDDSPLMVYS
QRQVSALQDRLSLPVALGMTYGQPAIKSGIELLEEQGCDEIIILPLYPQYSRTTTAAVFDQIGKQYKTTSVLPNFTMVHN
YHDHPLYIKALAESIRLSWKEKGKGDYVLCSYHGIPQRFVDNGDIYAEHCIRTTELLAEELGLNSEQIGMSYQSRFGREA
WLQPYTSETLKELAPKGIKSLDIISPAFSVDCLETLEELSEECKEIYMTAGGEKYTFIPCLNDDELHIEMMAAIVSSKIS
RS
>Mature_322_residues
MNNKKAGVLLVNLGTPTAPTAAAVKTFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYQSVWMEDDSPLMVYS
QRQVSALQDRLSLPVALGMTYGQPAIKSGIELLEEQGCDEIIILPLYPQYSRTTTAAVFDQIGKQYKTTSVLPNFTMVHN
YHDHPLYIKALAESIRLSWKEKGKGDYVLCSYHGIPQRFVDNGDIYAEHCIRTTELLAEELGLNSEQIGMSYQSRFGREA
WLQPYTSETLKELAPKGIKSLDIISPAFSVDCLETLEELSEECKEIYMTAGGEKYTFIPCLNDDELHIEMMAAIVSSKIS
RS

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=26.3636363636364, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=26.3636363636364, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=51.5723270440252, Blast_Score=340, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6324750, Length=327, Percent_Identity=23.8532110091743, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=26.5861027190332, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24651774, Length=262, Percent_Identity=26.3358778625954, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=28.2352941176471, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_ALISL (B6EHK1)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262324.1
- GeneID:   6988225
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0816
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36235; Mature: 36235

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKKAGVLLVNLGTPTAPTAAAVKTFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPK
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHEECCCCCH
VAKLYQSVWMEDDSPLMVYSQRQVSALQDRLSLPVALGMTYGQPAIKSGIELLEEQGCDE
HHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCE
IIILPLYPQYSRTTTAAVFDQIGKQYKTTSVLPNFTMVHNYHDHPLYIKALAESIRLSWK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
EKGKGDYVLCSYHGIPQRFVDNGDIYAEHCIRTTELLAEELGLNSEQIGMSYQSRFGREA
CCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCHHH
WLQPYTSETLKELAPKGIKSLDIISPAFSVDCLETLEELSEECKEIYMTAGGEKYTFIPC
HCCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
LNDDELHIEMMAAIVSSKISRS
CCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNKKAGVLLVNLGTPTAPTAAAVKTFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPK
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHEECCCCCH
VAKLYQSVWMEDDSPLMVYSQRQVSALQDRLSLPVALGMTYGQPAIKSGIELLEEQGCDE
HHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCE
IIILPLYPQYSRTTTAAVFDQIGKQYKTTSVLPNFTMVHNYHDHPLYIKALAESIRLSWK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
EKGKGDYVLCSYHGIPQRFVDNGDIYAEHCIRTTELLAEELGLNSEQIGMSYQSRFGREA
CCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCHHH
WLQPYTSETLKELAPKGIKSLDIISPAFSVDCLETLEELSEECKEIYMTAGGEKYTFIPC
HCCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
LNDDELHIEMMAAIVSSKISRS
CCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA