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The map label for this gene is mutM

Identifier: 209551935

GI number: 209551935

Start: 4535561

End: 4536466

Strand: Direct

Name: mutM

Synonym: Rleg2_4368

Alternate gene names: 209551935

Gene position: 4535561-4536466 (Clockwise)

Preceding gene: 209551926

Following gene: 209551936

Centisome position: 99.95

GC content: 64.24

Gene sequence:

>906_bases
ATGCCGGAATTGCCAGAAGTCGAAACGGTAAAACGCGGCCTGGCGCCGGCGATGGAGGGTGCTCGTGTCGCCAAGCTTGA
GCTGCGCCGCGGCGATCTGCGCTTTCCCTTTCCCGACGCTTTCGCCGACAGGGTTTCCGGTCGCACCATCGTCAGCCTTG
GCCGTCGCGCCAAATATCTGCTGGTCGATCTCGACGACGGCAACACGCTGATTTCCCATCTCGGCATGTCCGGCTCTTTT
CGCATCGAGGAGGGTCGCATCGAGGAGGGCGCTGGAGCGGCCACGCCTGGCGAATTCCACCATGCCCGCTCGAAGGACGA
GAAGCACGACCACGTCGTCTTTCATCTGGAAAGTCCAGCCGGTCCGCGCCGTGTCGTTTATAACGATCCGCGCCGTTTCG
GCTTCATGGATATGGTGGGGCGCGCCGACCTTGCCGCCCATCCCTTCTTCCGTGATCTCGGCCCGGAGCCGACGGGAAAC
GAGCTCGGCGCCGCCTATCTCGCCGAGCGCTTCCGCCACAAGGCGCAGCCGTTGAAGAGTGCGCTGCTCGACCAGAAGAA
CATTGCCGGTCTCGGCAATATATATGTCTGCGAGGCGCTGTGGCGCGCCCACCTTTCGCCGATCCGCGCCGCCGGCACGC
TGGCAACCGCAGGCGGCCGGCCGAAAGAGCAGCTTAACCTGCTCGTGGCCTCGATCCGCGATGTCATTGCCGATGCGATC
ACCGCCGGCGGATCGTCGCTGCGCGACCATATCCAGACCGACGGATCGCTCGGCTATTTCCAGCATTCCTTCTCCGTCTA
TGATCGCGAAGGTCAGGCTTGCCGCACGCCCGGCTGCGGCGGTACGGTCGCCCGCATCGTCCAGGCGGGCCGCTCCACCT
TCTATTGCGCCACCTGCCAGAAGTAA

Upstream 100 bases:

>100_bases
CCGCGCGCGACGTTATCACTGGGCCGCGCTCTCCGCGGACCACTGGCGCTATAGCGCACATCGTCCTCGGTTGAAACACG
TTAGATACAGATGGGTTAAG

Downstream 100 bases:

>100_bases
GAACGGGAGAACAGCATGGCCTATGAGACCCTGATCGTCGAAACCCGAGGCAATGTCGGCCTCGTCACGCTGAACCGACC
GCAGGCGCTGAACGCGCTGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPELPEVETVKRGLAPAMEGARVAKLELRRGDLRFPFPDAFADRVSGRTIVSLGRRAKYLLVDLDDGNTLISHLGMSGSF
RIEEGRIEEGAGAATPGEFHHARSKDEKHDHVVFHLESPAGPRRVVYNDPRRFGFMDMVGRADLAAHPFFRDLGPEPTGN
ELGAAYLAERFRHKAQPLKSALLDQKNIAGLGNIYVCEALWRAHLSPIRAAGTLATAGGRPKEQLNLLVASIRDVIADAI
TAGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACRTPGCGGTVARIVQAGRSTFYCATCQK

Sequences:

>Translated_301_residues
MPELPEVETVKRGLAPAMEGARVAKLELRRGDLRFPFPDAFADRVSGRTIVSLGRRAKYLLVDLDDGNTLISHLGMSGSF
RIEEGRIEEGAGAATPGEFHHARSKDEKHDHVVFHLESPAGPRRVVYNDPRRFGFMDMVGRADLAAHPFFRDLGPEPTGN
ELGAAYLAERFRHKAQPLKSALLDQKNIAGLGNIYVCEALWRAHLSPIRAAGTLATAGGRPKEQLNLLVASIRDVIADAI
TAGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACRTPGCGGTVARIVQAGRSTFYCATCQK
>Mature_300_residues
PELPEVETVKRGLAPAMEGARVAKLELRRGDLRFPFPDAFADRVSGRTIVSLGRRAKYLLVDLDDGNTLISHLGMSGSFR
IEEGRIEEGAGAATPGEFHHARSKDEKHDHVVFHLESPAGPRRVVYNDPRRFGFMDMVGRADLAAHPFFRDLGPEPTGNE
LGAAYLAERFRHKAQPLKSALLDQKNIAGLGNIYVCEALWRAHLSPIRAAGTLATAGGRPKEQLNLLVASIRDVIADAIT
AGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACRTPGCGGTVARIVQAGRSTFYCATCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=301, Percent_Identity=38.5382059800665, Blast_Score=192, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_RHILW (B5ZYK9)

Other databases:

- EMBL:   CP001191
- RefSeq:   YP_002283852.1
- ProteinModelPortal:   B5ZYK9
- SMR:   B5ZYK9
- GeneID:   6983142
- GenomeReviews:   CP001191_GR
- KEGG:   rlt:Rleg2_4368
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32791; Mature: 32659

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 291-291 BINDING 109-109 BINDING 131-131 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVKRGLAPAMEGARVAKLELRRGDLRFPFPDAFADRVSGRTIVSLGRRAKYL
CCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHCCCCEEE
LVDLDDGNTLISHLGMSGSFRIEEGRIEEGAGAATPGEFHHARSKDEKHDHVVFHLESPA
EEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCC
GPRRVVYNDPRRFGFMDMVGRADLAAHPFFRDLGPEPTGNELGAAYLAERFRHKAQPLKS
CCCEEEECCCCCCCHHHHHCCCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLDQKNIAGLGNIYVCEALWRAHLSPIRAAGTLATAGGRPKEQLNLLVASIRDVIADAI
HHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHH
TAGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACRTPGCGGTVARIVQAGRSTFYCATCQ
HCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECC
K
C
>Mature Secondary Structure 
PELPEVETVKRGLAPAMEGARVAKLELRRGDLRFPFPDAFADRVSGRTIVSLGRRAKYL
CCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHCCCCEEE
LVDLDDGNTLISHLGMSGSFRIEEGRIEEGAGAATPGEFHHARSKDEKHDHVVFHLESPA
EEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCC
GPRRVVYNDPRRFGFMDMVGRADLAAHPFFRDLGPEPTGNELGAAYLAERFRHKAQPLKS
CCCEEEECCCCCCCHHHHHCCCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLDQKNIAGLGNIYVCEALWRAHLSPIRAAGTLATAGGRPKEQLNLLVASIRDVIADAI
HHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHH
TAGGSSLRDHIQTDGSLGYFQHSFSVYDREGQACRTPGCGGTVARIVQAGRSTFYCATCQ
HCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA