Click here to switch to the map view.

The map label for this gene is 209551926

Identifier: 209551926

GI number: 209551926

Start: 4524922

End: 4525308

Strand: Direct

Name: 209551926

Synonym: Rleg2_4359

Alternate gene names: NA

Gene position: 4524922-4525308 (Clockwise)

Preceding gene: 209551925

Following gene: 209551935

Centisome position: 99.71

GC content: 59.43

Gene sequence:

>387_bases
ATGATCCGCATAGACCGTCTCGATCATCTCGTGCTGACCGTTGCCGATCTCGCAGCCACCTGTGATTTCTATTCCCGCAT
CCTCGGCATGTCGGTCCAATCCTTCGCGGAAGGCCGAAAGGCGCTGAAATTCGGCAGGCAGAAGATCAACCTGCATCAGG
CCGGCCACGAATTCGAACCCAAGGCAAAACATGCCGCCCCCGGCTCCGGTGACCTCTGCTTCATCGCCGAGGCACCGCTT
GCCGACGTCATCGCCCATCTGCAGGCGTCGGGCATTGTGATCGAAGAAGGTCCGGTCGAGCGCACCGGCGCGACCGGGCG
CCTGCGCTCGATCTATTTCAGAGATCCCGACGGCAATCTCATCGAAGTTTCGAATCTGATCGATTGA

Upstream 100 bases:

>100_bases
CGATGGAAGGCTGGACCGCCGTCGTCCTTTTCACGCTGGCCATGCTGGCGCTGGCCTTTATCTCCGCTTGTGTGGCGCAG
CACTTCGCACGGAGAAAAGC

Downstream 100 bases:

>100_bases
TCCTCGATTTGGCCATACAGGCCGCCCGACTCAATCCAGCCGGATATAGGGCACGTCCTTCTTCGCCACCTCGTCCAGCG
CCTCCTCGTAGCCAGCATCG

Product: glyoxalase/bleomycin resistance protein/dioxygenase

Products: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MIRIDRLDHLVLTVADLAATCDFYSRILGMSVQSFAEGRKALKFGRQKINLHQAGHEFEPKAKHAAPGSGDLCFIAEAPL
ADVIAHLQASGIVIEEGPVERTGATGRLRSIYFRDPDGNLIEVSNLID

Sequences:

>Translated_128_residues
MIRIDRLDHLVLTVADLAATCDFYSRILGMSVQSFAEGRKALKFGRQKINLHQAGHEFEPKAKHAAPGSGDLCFIAEAPL
ADVIAHLQASGIVIEEGPVERTGATGRLRSIYFRDPDGNLIEVSNLID
>Mature_128_residues
MIRIDRLDHLVLTVADLAATCDFYSRILGMSVQSFAEGRKALKFGRQKINLHQAGHEFEPKAKHAAPGSGDLCFIAEAPL
ADVIAHLQASGIVIEEGPVERTGATGRLRSIYFRDPDGNLIEVSNLID

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=124, Percent_Identity=62.9032258064516, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.39

Molecular weight: Translated: 13955; Mature: 13955

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIDRLDHLVLTVADLAATCDFYSRILGMSVQSFAEGRKALKFGRQKINLHQAGHEFEP
CEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KAKHAAPGSGDLCFIAEAPLADVIAHLQASGIVIEEGPVERTGATGRLRSIYFRDPDGNL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCCCE
IEVSNLID
EECCCCCC
>Mature Secondary Structure
MIRIDRLDHLVLTVADLAATCDFYSRILGMSVQSFAEGRKALKFGRQKINLHQAGHEFEP
CEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KAKHAAPGSGDLCFIAEAPLADVIAHLQASGIVIEEGPVERTGATGRLRSIYFRDPDGNL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCCCE
IEVSNLID
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: biphenyl-2,3-diol; O2

Specific reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]