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The map label for this gene is hisI [H]

Identifier: 209549444

GI number: 209549444

Start: 1898570

End: 1899022

Strand: Direct

Name: hisI [H]

Synonym: Rleg2_1850

Alternate gene names: 209549444

Gene position: 1898570-1899022 (Clockwise)

Preceding gene: 209549443

Following gene: 209549445

Centisome position: 41.84

GC content: 60.49

Gene sequence:

>453_bases
ATGAGCCAATTGATCTTCAGTCAACCATCCGAGGACAAGTCGGCGTTGGAAGACGCCGGCGATTTCACGCCGCGTTTCGA
CGACCGTGGCCTGATCACCGCGATCGTCACCGACGCCGGCGACGGCGAGTTGCTGATGGTGGCGCACATGAATGCCCAGG
CGCTGGCGCTGACCATCCAGACCGGCACGGCCCATTATTTCAGCCGGTCGCGCGGCAAGATCTGGAAGAAGGGCGAGACC
TCGGGCAATCTCCAGACGGTGAAGGAAATTCGCACCGATTGCGATCAGGACGCCATCTGGCTGAAGGTCGAGGTCGCCGG
CCATGACGCCACCTGTCACACCGGCCGCCGCTCCTGCTTCTATCGGACAATCGCGCTTCGGGATGGAAAGCCGATGCTTG
ATATCGTCGACGACGAGCGTCATTTCGATCCGCAGGACGTTTACGGAAAATAG

Upstream 100 bases:

>100_bases
ACCACCTTTACCGGAACGTTCAAGACCGAGCCGGCCGATCAGGCCCGTTTCATGACCATGGTGCGGAGCCGCTGATACCG
GCTCCCTCAGGAGGGCCGCG

Downstream 100 bases:

>100_bases
GCCCGGAAAATAGCCTGGGAAAATGGAGCCGGAATTTCCCGGCATCTGCTCCTTATTGCGCCAGAAGTCGCCTCTATATA
CCATTTGGAAACTGATCGGG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSQLIFSQPSEDKSALEDAGDFTPRFDDRGLITAIVTDAGDGELLMVAHMNAQALALTIQTGTAHYFSRSRGKIWKKGET
SGNLQTVKEIRTDCDQDAIWLKVEVAGHDATCHTGRRSCFYRTIALRDGKPMLDIVDDERHFDPQDVYGK

Sequences:

>Translated_150_residues
MSQLIFSQPSEDKSALEDAGDFTPRFDDRGLITAIVTDAGDGELLMVAHMNAQALALTIQTGTAHYFSRSRGKIWKKGET
SGNLQTVKEIRTDCDQDAIWLKVEVAGHDATCHTGRRSCFYRTIALRDGKPMLDIVDDERHFDPQDVYGK
>Mature_149_residues
SQLIFSQPSEDKSALEDAGDFTPRFDDRGLITAIVTDAGDGELLMVAHMNAQALALTIQTGTAHYFSRSRGKIWKKGETS
GNLQTVKEIRTDCDQDAIWLKVEVAGHDATCHTGRRSCFYRTIALRDGKPMLDIVDDERHFDPQDVYGK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=43.956043956044, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=41.7582417582418, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 16720; Mature: 16589

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLIFSQPSEDKSALEDAGDFTPRFDDRGLITAIVTDAGDGELLMVAHMNAQALALTIQ
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEEEEEE
TGTAHYFSRSRGKIWKKGETSGNLQTVKEIRTDCDQDAIWLKVEVAGHDATCHTGRRSCF
CCCCHHHHCCCCCEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEE
YRTIALRDGKPMLDIVDDERHFDPQDVYGK
EEEEEECCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SQLIFSQPSEDKSALEDAGDFTPRFDDRGLITAIVTDAGDGELLMVAHMNAQALALTIQ
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEEEEEE
TGTAHYFSRSRGKIWKKGETSGNLQTVKEIRTDCDQDAIWLKVEVAGHDATCHTGRRSCF
CCCCHHHHCCCCCEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEE
YRTIALRDGKPMLDIVDDERHFDPQDVYGK
EEEEEECCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA