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The map label for this gene is folE [H]

Identifier: 209549443

GI number: 209549443

Start: 1897930

End: 1898544

Strand: Direct

Name: folE [H]

Synonym: Rleg2_1849

Alternate gene names: 209549443

Gene position: 1897930-1898544 (Clockwise)

Preceding gene: 209549438

Following gene: 209549444

Centisome position: 41.82

GC content: 62.44

Gene sequence:

>615_bases
ATGGACGCCATCGTAAAGAACTTTCCGCAGACGAACCGCGACTCCGATCGCCCCTCCCAGCAGGAGGCGGAGGAAGCCGT
TCGTGTCCTGCTGCGCTGGGCCGGTGAGAACCCTACGCGCGAAGGCCTGATCGAAACGCCGGCGCGTGTCGTCAAATCCT
ACCGCGAGCTTTTTGCCGGTTACGACATGGCGCCGGAAGACGTGCTCGGCCGCACCTTCGAAGAGGTCGCCGGCTACGAC
GACATGGTTCTCGTCAAGGACATACCGTTCTTCTCGCATTGCGAACATCACGTGGTGCCGATCATCGGCAAGGCTCACGT
CGCCTACATGCCGGACGGGCGCGTGCTCGGCCTGTCGAAGATTGCCCGTGTCGTCGAGATCTATGGCCGCCGTCTGCAGA
CCCAGGAAACGATGACAGCGCAGATCGCCCGGGCGATCGACGATACGCTTAACCCGCGCGGTGTCGCGGTGATGATCGAG
GCCGAACATATGTGCATGGCGATGCGCGGCGTTCAGAAGCAGGGCTCGACCACGTTGACGACCACCTTTACCGGAACGTT
CAAGACCGAGCCGGCCGATCAGGCCCGTTTCATGACCATGGTGCGGAGCCGCTGA

Upstream 100 bases:

>100_bases
AGCCCCGGAGCCTGCCAAAGGTGCATGAATTCCCGCATGGGATTGACCAGTGGCGATTCCGACAGATCGGTCCGCGGTGC
GGACCAGGAGACCATTGTTC

Downstream 100 bases:

>100_bases
TACCGGCTCCCTCAGGAGGGCCGCGATGAGCCAATTGATCTTCAGTCAACCATCCGAGGACAAGTCGGCGTTGGAAGACG
CCGGCGATTTCACGCCGCGT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MDAIVKNFPQTNRDSDRPSQQEAEEAVRVLLRWAGENPTREGLIETPARVVKSYRELFAGYDMAPEDVLGRTFEEVAGYD
DMVLVKDIPFFSHCEHHVVPIIGKAHVAYMPDGRVLGLSKIARVVEIYGRRLQTQETMTAQIARAIDDTLNPRGVAVMIE
AEHMCMAMRGVQKQGSTTLTTTFTGTFKTEPADQARFMTMVRSR

Sequences:

>Translated_204_residues
MDAIVKNFPQTNRDSDRPSQQEAEEAVRVLLRWAGENPTREGLIETPARVVKSYRELFAGYDMAPEDVLGRTFEEVAGYD
DMVLVKDIPFFSHCEHHVVPIIGKAHVAYMPDGRVLGLSKIARVVEIYGRRLQTQETMTAQIARAIDDTLNPRGVAVMIE
AEHMCMAMRGVQKQGSTTLTTTFTGTFKTEPADQARFMTMVRSR
>Mature_204_residues
MDAIVKNFPQTNRDSDRPSQQEAEEAVRVLLRWAGENPTREGLIETPARVVKSYRELFAGYDMAPEDVLGRTFEEVAGYD
DMVLVKDIPFFSHCEHHVVPIIGKAHVAYMPDGRVLGLSKIARVVEIYGRRLQTQETMTAQIARAIDDTLNPRGVAVMIE
AEHMCMAMRGVQKQGSTTLTTTFTGTFKTEPADQARFMTMVRSR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=204, Percent_Identity=47.0588235294118, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI4503949, Length=204, Percent_Identity=47.0588235294118, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI66932970, Length=162, Percent_Identity=46.2962962962963, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI66932972, Length=162, Percent_Identity=46.2962962962963, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI1788476, Length=165, Percent_Identity=43.030303030303, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=180, Percent_Identity=45.5555555555556, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321706, Length=186, Percent_Identity=44.0860215053763, Blast_Score=167, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24656782, Length=180, Percent_Identity=50.5555555555556, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24656796, Length=180, Percent_Identity=50.5555555555556, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24656791, Length=180, Percent_Identity=50.5555555555556, Blast_Score=176, Evalue=8e-45,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22950; Mature: 22950

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAIVKNFPQTNRDSDRPSQQEAEEAVRVLLRWAGENPTREGLIETPARVVKSYRELFAG
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
YDMAPEDVLGRTFEEVAGYDDMVLVKDIPFFSHCEHHVVPIIGKAHVAYMPDGRVLGLSK
CCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCEEEECCEEEEECCCCCEECHHH
IARVVEIYGRRLQTQETMTAQIARAIDDTLNPRGVAVMIEAEHMCMAMRGVQKQGSTTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEE
TTFTGTFKTEPADQARFMTMVRSR
EEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDAIVKNFPQTNRDSDRPSQQEAEEAVRVLLRWAGENPTREGLIETPARVVKSYRELFAG
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
YDMAPEDVLGRTFEEVAGYDDMVLVKDIPFFSHCEHHVVPIIGKAHVAYMPDGRVLGLSK
CCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCEEEECCEEEEECCCCCEECHHH
IARVVEIYGRRLQTQETMTAQIARAIDDTLNPRGVAVMIEAEHMCMAMRGVQKQGSTTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEE
TTFTGTFKTEPADQARFMTMVRSR
EEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA