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The map label for this gene is vllY [H]

Identifier: 209549009

GI number: 209549009

Start: 1426208

End: 1427317

Strand: Direct

Name: vllY [H]

Synonym: Rleg2_1406

Alternate gene names: 209549009

Gene position: 1426208-1427317 (Clockwise)

Preceding gene: 209549007

Following gene: 209549010

Centisome position: 31.43

GC content: 59.37

Gene sequence:

>1110_bases
ATGGGTCCTTTCCCGCACGATGCGCCGCCATCCGAAATCACCGCGGACAACCCGGCCGGCACCGACGGTTTCGAATTCGT
CGAGTTCGCACATCCCGAACCCGAGAAGCTCAGCGAACTTTTCACGCGCATGGGCTATGTCGCGGTCGCCAGGCACAAGA
CGAAAGACATCACCGTCTGGCGCCAGGGTGACATCAACTATGTCGTCAATGCCGAGCCCGGCAGCCATGCCGCCCGCTTT
GTCGGGCAACATGGTCCCTGCGCCGCATCGATGGCCTGGCGTGTCGTCGATGCCAAACATGCTTTCGACCATGCGGTGTC
GAAAGGCGCCGTTCCCTATGAAGGCGACGACAAGATGCTCGACGTTCCGGCCATCACAGGCATCGGCGGCTCGCTGCTCT
ATTTCGTCGAGACCTATGGGGCGAAGGGGTCGGCTTACGAGGCCGAGTTCGATTGGCTGGGTGAGCGCAATCCGCGACCC
GAGGGGATCGGTTTCTATTATCTCGACCATCTCACCCACAACGTCTTCCGCGGCAATATGGACAAGTGGTGGGATTTTTA
CCGCGAGCTGTTCAACTTCAAGCAGATCCACTTCTTCGACATTGACGGCCGCATCACCGGCCTGGTCAGCCGCGCCATCA
CCTCGCCCTGCGGCAAGATCCGCATTCCGCTGAATGAATCGAAGGACGACACCAGCCAGATCGAGGAATATCTGAAGAAG
TACCGGGGCGAGGGCATCCAGCACATCGCCGTCGGCACCGAGGACATTTATGGGGCGACCGACAAGCTCGCCGATAACGG
CCTGCGCTTCATGCCGGGTCCGCCGGAGACCTATTACAACATGTCCTATGAGCGGGTGAACGGCCATAGCGAACCCATCG
AACGCATGAAGAAACACGGCATCCTGATCGACGGGGAGGGCGTGGTGAATGGCGGCATGACGAAAATCCTGCTGCAGATC
TTTTCCAAAACCGTCATCGGCCCGATCTTCTTCGAATTTATCCAGCGCAAGGGCGACGAGGGTTTCGGCGAAGGCAACTT
CCGGGCGCTGTTCGAGTCGATCGAAGCCGATCAGATCAAGCGTGGTGTCATCGGGACGGCAGCGGAGTAA

Upstream 100 bases:

>100_bases
CGTGCATAATATCTTCTCCAAGCATGAAGAATGCAAGGATTTTGCACGTGTTTTGCGCCACACTTTGCGCAGTTAAACTC
CATCTCGTCAGGAGGAGAAA

Downstream 100 bases:

>100_bases
ACTCCTGAGCGCCGCGTCTCTGAACGATGCGCGGCGCTGGAGGGATTGAGGGAGGAGTTGAGCAATGGACCAGACATCGA
TCCAGGCTTCCGGCGGTGAA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MGPFPHDAPPSEITADNPAGTDGFEFVEFAHPEPEKLSELFTRMGYVAVARHKTKDITVWRQGDINYVVNAEPGSHAARF
VGQHGPCAASMAWRVVDAKHAFDHAVSKGAVPYEGDDKMLDVPAITGIGGSLLYFVETYGAKGSAYEAEFDWLGERNPRP
EGIGFYYLDHLTHNVFRGNMDKWWDFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLKK
YRGEGIQHIAVGTEDIYGATDKLADNGLRFMPGPPETYYNMSYERVNGHSEPIERMKKHGILIDGEGVVNGGMTKILLQI
FSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIKRGVIGTAAE

Sequences:

>Translated_369_residues
MGPFPHDAPPSEITADNPAGTDGFEFVEFAHPEPEKLSELFTRMGYVAVARHKTKDITVWRQGDINYVVNAEPGSHAARF
VGQHGPCAASMAWRVVDAKHAFDHAVSKGAVPYEGDDKMLDVPAITGIGGSLLYFVETYGAKGSAYEAEFDWLGERNPRP
EGIGFYYLDHLTHNVFRGNMDKWWDFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLKK
YRGEGIQHIAVGTEDIYGATDKLADNGLRFMPGPPETYYNMSYERVNGHSEPIERMKKHGILIDGEGVVNGGMTKILLQI
FSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIKRGVIGTAAE
>Mature_368_residues
GPFPHDAPPSEITADNPAGTDGFEFVEFAHPEPEKLSELFTRMGYVAVARHKTKDITVWRQGDINYVVNAEPGSHAARFV
GQHGPCAASMAWRVVDAKHAFDHAVSKGAVPYEGDDKMLDVPAITGIGGSLLYFVETYGAKGSAYEAEFDWLGERNPRPE
GIGFYYLDHLTHNVFRGNMDKWWDFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLKKY
RGEGIQHIAVGTEDIYGATDKLADNGLRFMPGPPETYYNMSYERVNGHSEPIERMKKHGILIDGEGVVNGGMTKILLQIF
SKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIKRGVIGTAAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=337, Percent_Identity=27.893175074184, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4504477, Length=337, Percent_Identity=27.893175074184, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI14249394, Length=375, Percent_Identity=26.1333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=322, Percent_Identity=32.6086956521739, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17550752, Length=211, Percent_Identity=30.3317535545024, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667510, Length=335, Percent_Identity=31.6417910447761, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356105, Length=306, Percent_Identity=32.0261437908497, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 41245; Mature: 41114

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAPPSEITADNPAGTDGFEFVEFAHPEPEKLSELFTRMGYVAVARHKTKDITVW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEE
RQGDINYVVNAEPGSHAARFVGQHGPCAASMAWRVVDAKHAFDHAVSKGAVPYEGDDKML
EECCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DVPAITGIGGSLLYFVETYGAKGSAYEAEFDWLGERNPRPEGIGFYYLDHLTHNVFRGNM
ECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHCCCH
DKWWDFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLKK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
YRGEGIQHIAVGTEDIYGATDKLADNGLRFMPGPPETYYNMSYERVNGHSEPIERMKKHG
HCCCCEEEEEECCHHHHCCHHHHHCCCCEECCCCCHHHHCCCHHHCCCCHHHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIK
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVIGTAAE
HCCCCCCCC
>Mature Secondary Structure 
GPFPHDAPPSEITADNPAGTDGFEFVEFAHPEPEKLSELFTRMGYVAVARHKTKDITVW
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEE
RQGDINYVVNAEPGSHAARFVGQHGPCAASMAWRVVDAKHAFDHAVSKGAVPYEGDDKML
EECCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DVPAITGIGGSLLYFVETYGAKGSAYEAEFDWLGERNPRPEGIGFYYLDHLTHNVFRGNM
ECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHCCCH
DKWWDFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLKK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
YRGEGIQHIAVGTEDIYGATDKLADNGLRFMPGPPETYYNMSYERVNGHSEPIERMKKHG
HCCCCEEEEEECCHHHHCCHHHHHCCCCEECCCCCHHHHCCCHHHCCCCHHHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIK
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVIGTAAE
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA