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The map label for this gene is hmgA [H]

Identifier: 209549010

GI number: 209549010

Start: 1427382

End: 1428743

Strand: Direct

Name: hmgA [H]

Synonym: Rleg2_1407

Alternate gene names: 209549010

Gene position: 1427382-1428743 (Clockwise)

Preceding gene: 209549009

Following gene: 209549011

Centisome position: 31.45

GC content: 60.28

Gene sequence:

>1362_bases
ATGGACCAGACATCGATCCAGGCTTCCGGCGGTGAATCTGCGACGGCAAGCACGCTGAAATATATGCCGGGCTTCGGCAA
TGATTTCGAGACCGAGTCGCTTCCCGGCGCTTTGCCGCAGGGTCAGAACAGCCCGCAGAAATGCAATTACGGTCTTTATG
CCGAGCAGCTTTCCGGCTCGCCTTTCACTGCGCCGCGCGGGACGAACGAAAGATCCTGGCTTTACCGCATTCGCCCGAGC
GTGCGCCACACCCGCCGCTTCTCCAACGCTTCCTACCCGCTCTGGAAGACCGCGCCTTGCCTCGACGAGCATTCGCTGCC
TCTCGGCCAGCTTCGCTGGGATCCCATCCCCGCACCTGAGGAGAGGCTGACATTTCTTGAAGGGGTGCGGACCATCACCA
CGGCAGGCGATGCCGCAACCCAGGTCGGCATGTCGGCGCATGCCTATGTCTTCAACCAGGACATGGTCGACGATTACTTC
TTCAATGCCGATGGCGAATTGCTGATCGTGCCGCAGCTCGGCGCTCTCAGGGTGTTCACCGAAATGGGCATCATGGACGT
CGAGCCCCTGGAAATATGCCTCATCCCACGCGGCATGATGTTCAAGATCCTCAAGACCGGCGAGCAGGCGGTCTGGCGCG
GCTATATATGCGAAAACTACGGTGCCAAATTCACGCTGCCGGACCGTGGGCCGATCGGCGCCAACTGCCTGGCAAACCCG
CGCGACTTCAAGACACCCGTCGCCGCCTTCGAGGACAAGGAAACACCTTGCCGTGTCCACGTGAAATGGTGCGGAAAATT
CTATGTGACGGAGATCGGCCACTCGCCGCTCGACGTGGTGGCCTGGCACGGCAACTACGCCCCGTTCAAATATGACCTCA
GAACATTTTCTCCGGTCGGCGCCATCCGCTTCGATCACCCCGATCCGTCGATTTTCTCGGTGCTGACGGCGCCGACCGAG
GATGCCGGGACGGCGAATGTCGATTTCGTCATCTTTCCGCCGCGCTGGCTGGTCGCCGAGCACACCTTCCGTCCACCCTG
GTATCACCGCAACATCATGAGCGAGTTCATGGGCCTGATCCACGGCCAGTATGACGCCAAGGAGGAGGGCTTCGTGCCTG
GCGGTATGAGCCTTCACAATATGATGCTTCCCCACGGGCCGGACGCGCTCGCCTTCGAAAAGGCAGCCAATGCCGAGCTG
AAACCTGTGAAGCTCGACCACACCATGGCCTTCATGTTCGAGACCCGATACCCGCAGCAGCTGACGAAATATGCGGCCGA
GCTGGAAACACTGCAGGACGATTATCTCGAATGCTGGGACGGCCTGGAGCGCAAGTTCGACGGCACCCCGGGTATTAAGT
GA

Upstream 100 bases:

>100_bases
ATCAAGCGTGGTGTCATCGGGACGGCAGCGGAGTAAACTCCTGAGCGCCGCGTCTCTGAACGATGCGCGGCGCTGGAGGG
ATTGAGGGAGGAGTTGAGCA

Downstream 100 bases:

>100_bases
CAGCATCGGAATTGGAACATGAAACTTGCGACCTTGAAGGACTCCACCCGGGACGGCCGCCTCGTCGTCGTTTCCCGCGA
CCTGACCCGCTGCTCGGAAG

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPEERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYF
FNADGELLIVPQLGALRVFTEMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVGAIRFDHPDPSIFSVLTAPTE
DAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAEL
KPVKLDHTMAFMFETRYPQQLTKYAAELETLQDDYLECWDGLERKFDGTPGIK

Sequences:

>Translated_453_residues
MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPEERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYF
FNADGELLIVPQLGALRVFTEMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVGAIRFDHPDPSIFSVLTAPTE
DAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAEL
KPVKLDHTMAFMFETRYPQQLTKYAAELETLQDDYLECWDGLERKFDGTPGIK
>Mature_453_residues
MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPEERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYF
FNADGELLIVPQLGALRVFTEMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVGAIRFDHPDPSIFSVLTAPTE
DAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAEL
KPVKLDHTMAFMFETRYPQQLTKYAAELETLQDDYLECWDGLERKFDGTPGIK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=439, Percent_Identity=50.7972665148064, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17507969, Length=440, Percent_Identity=51.1363636363636, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24583650, Length=443, Percent_Identity=51.2415349887133, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50843; Mature: 50843

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGS
CCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCC
PFTAPRGTNERSWLYRIRPSVRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPE
CCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCH
ERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYFFNADGELLIVPQLGALRVFT
HHHHHHHHHHHEECCCCHHHHHCCCEEEEEECCCCHHHEEECCCCCEEEEECCCHHHHHH
EMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANP
HCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHCCEEECCCCCEEECCCCCCCCCCCCCCC
RDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVG
HHCCCCHHHCCCCCCCEEEEEEECCEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCCC
AIRFDHPDPSIFSVLTAPTEDAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLI
EEEECCCCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHH
HGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAELKPVKLDHTMAFMFETRYPQQ
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCHHH
LTKYAAELETLQDDYLECWDGLERKFDGTPGIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGS
CCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCC
PFTAPRGTNERSWLYRIRPSVRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPE
CCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCH
ERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYFFNADGELLIVPQLGALRVFT
HHHHHHHHHHHEECCCCHHHHHCCCEEEEEECCCCHHHEEECCCCCEEEEECCCHHHHHH
EMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANP
HCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHCCEEECCCCCEEECCCCCCCCCCCCCCC
RDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVG
HHCCCCHHHCCCCCCCEEEEEEECCEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCCC
AIRFDHPDPSIFSVLTAPTEDAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLI
EEEECCCCCCEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHH
HGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAELKPVKLDHTMAFMFETRYPQQ
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCHHH
LTKYAAELETLQDDYLECWDGLERKFDGTPGIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA