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The map label for this gene is cusR [H]

Identifier: 209548528

GI number: 209548528

Start: 939754

End: 940500

Strand: Direct

Name: cusR [H]

Synonym: Rleg2_0925

Alternate gene names: 209548528

Gene position: 939754-940500 (Clockwise)

Preceding gene: 209548527

Following gene: 209548529

Centisome position: 20.71

GC content: 63.05

Gene sequence:

>747_bases
ATGAGCGCCGCCCCGCAGGAAGATGCTTTGAGCCTTGCCGAAACGCAGCCGGTGGGTAATGTCGGCCGCATGAAGATTCT
CATCATCGAAGATGATCTCGAAGCCGCCGTCTACCTCACGAAAGCCTTTCGCGAGGCGGGCATCGTCGCCGATCACGCCA
GCGACGGCGAGGCCGGCCTGTTCATGGGCTCGGAAAATACCTACGACGTCATCGTCATCGATCGCATGCTGCCGCGCCGG
GACGGGCTTTCCGTCATCAGCGAGCTCCGCCGCAAGGCGATCCACACGCCGGTTCTCATTCTCTCGGCCCTCGGCCAGGT
CGATGACCGCGTCACCGGTCTGCGCGCCGGCGGCGACGACTACCTGCCGAAGCCCTATGCCTTCAGCGAATTGCTGGCGC
GCGTCGAGGTGCTCGGCCGCCGCAAGGGCACGCCGGATCAGGATGTCGTCTACCGCGTCGCCGATCTCGAGCTCGATCGG
CTCTCCCATGAGGTGCGCCGCGGCGGCAAAGAAATCCCGCTGCAGCCGCGCGAATTCCGCCTGCTCGAATATCTGATGAA
GAATGCCGGCCAGGTGGTAACCCGCACCATGCTGCTCGAAAATGTCTGGGACTATCACTTCGATCCGCAGACCAATGTTA
TCGACGTCCACGTCTCGCGCCTGCGCTCGAAGATCGAGAAGGACTACAGCCAGCCGCTCCTGAAGACCATCCGGGGCGCG
GGGTACATGATCAAGGACGAGGGATGA

Upstream 100 bases:

>100_bases
TCTTCCGATCAACGGCCAGGGCTGATCCCTCAAGAAAACAGCAGCCGTGCGGATGAAAATCCGCGCGGCTGATTCTTCTG
ACCTTTGAAGGATGATCGCG

Downstream 100 bases:

>100_bases
GCCGCTTCAGGGTTCTCTTCAAGTCCACTGCAGTCCGCCTCTCGGCACTCTATATCCTGCTTTTCGCCATCTGCGCCGCG
ACCCTCGTCTTCTATGTGAC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSAAPQEDALSLAETQPVGNVGRMKILIIEDDLEAAVYLTKAFREAGIVADHASDGEAGLFMGSENTYDVIVIDRMLPRR
DGLSVISELRRKAIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGTPDQDVVYRVADLELDR
LSHEVRRGGKEIPLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDYSQPLLKTIRGA
GYMIKDEG

Sequences:

>Translated_248_residues
MSAAPQEDALSLAETQPVGNVGRMKILIIEDDLEAAVYLTKAFREAGIVADHASDGEAGLFMGSENTYDVIVIDRMLPRR
DGLSVISELRRKAIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGTPDQDVVYRVADLELDR
LSHEVRRGGKEIPLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDYSQPLLKTIRGA
GYMIKDEG
>Mature_247_residues
SAAPQEDALSLAETQPVGNVGRMKILIIEDDLEAAVYLTKAFREAGIVADHASDGEAGLFMGSENTYDVIVIDRMLPRRD
GLSVISELRRKAIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGTPDQDVVYRVADLELDRL
SHEVRRGGKEIPLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDYSQPLLKTIRGAG
YMIKDEG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=44.5945945945946, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.1990950226244, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=34.8214285714286, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=32.7272727272727, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=34.5454545454545, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=30.7359307359307, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.4841628959276, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=30.3964757709251, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.0851063829787, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=29.7297297297297, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27801; Mature: 27670

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPQEDALSLAETQPVGNVGRMKILIIEDDLEAAVYLTKAFREAGIVADHASDGEAGL
CCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCEE
FMGSENTYDVIVIDRMLPRRDGLSVISELRRKAIHTPVLILSALGQVDDRVTGLRAGGDD
EECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
YLPKPYAFSELLARVEVLGRRKGTPDQDVVYRVADLELDRLSHEVRRGGKEIPLQPREFR
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDYSQPLLKTIRGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYMIKDEG
CEEEECCC
>Mature Secondary Structure 
SAAPQEDALSLAETQPVGNVGRMKILIIEDDLEAAVYLTKAFREAGIVADHASDGEAGL
CCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCEE
FMGSENTYDVIVIDRMLPRRDGLSVISELRRKAIHTPVLILSALGQVDDRVTGLRAGGDD
EECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
YLPKPYAFSELLARVEVLGRRKGTPDQDVVYRVADLELDRLSHEVRRGGKEIPLQPREFR
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDYSQPLLKTIRGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYMIKDEG
CEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]