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The map label for this gene is mprB [H]

Identifier: 209548529

GI number: 209548529

Start: 940497

End: 941906

Strand: Direct

Name: mprB [H]

Synonym: Rleg2_0926

Alternate gene names: 209548529

Gene position: 940497-941906 (Clockwise)

Preceding gene: 209548528

Following gene: 209548530

Centisome position: 20.73

GC content: 63.83

Gene sequence:

>1410_bases
ATGAGCCGCTTCAGGGTTCTCTTCAAGTCCACTGCAGTCCGCCTCTCGGCACTCTATATCCTGCTTTTCGCCATCTGCGC
CGCGACCCTCGTCTTCTATGTGACGGCGATGTCGGAACGGCTGCTGACCGGCCAGATCCGCGACGCCGTCAAGCAGGAGG
TGGAGCAGGTGCAGCGCGCCTATGATACCGGTGGCATGAACCTTCTGCTGCGCACGATGGAGCGGCGCGCCCGCCAGCCG
GGCGCAAATCTCTATGTCATCGCCGGTCCCTCGGGCGATATTCTCGCCGGTAACGTCGCTTCGGTGCAGCCCGGTGTCTT
CGAGGAAATCGGCTGGACGTCCGCACCCTTCATCTATCAGCGTTATACCGACAGCGGCGTCGAGCGCCGCCACAAGGCGA
TCGCCAATATCTTCGTGCTCGACAACGGCTTGCGGATCCTGATCGGCCGCGACCTTGGTGACCCCGAGCGTTTCCGGCTT
CTGGTGCGCCAGGCGTTGATGGTGGCGCTGGCGATCATGGGGCTTGGCGCCATCATCATCTGGTTCGCTATCGGCCGCAA
TGCGCTGAAACGCATCGACCGCATGTCGGATGCCAGCAAGAAGATCATGGCCGGCGACCTGTCGCAGCGCCTGCCGGTCG
GCGGCTCCGGCGATGAGTTCGACCGGTTGTCGATGTCTTTGAACACCATGCTGGAGCGCATCGAAAAGCTGAACGAGGGC
TTGCGGCAGGTTTCCGATAATATCGCCCACGATCTCAAGACGCCGCTGACGCGGCTGCGCAACAAGGCGGCCGATGCGCT
CGATATCGCCGATGGCGAGACGCGGCGAACCGCGCTCGAAGGCATTATTTCCGAATCGGACCAGCTGATCCGCACCTTCA
ACGCGCTGCTGATGATCTCCCGTGTCGAGGCTGGATCGGTGGCGGCCGAGATGTCGCCGGTGGAGCTTTCGGCGATCGTC
TCCGACAGCGCCGAGCTTTACGAACCGGCGGCCGAGGAAGCCGGGCTCGACCTCAGCGCCAGCGTCGAACCCGGCGTCGA
GGTCCAGGGTAATCGCGAACTGATCGGCCAGGCGATCTTCAACCTGCTCGACAATGCCATCAAATATTCCGCCGATACCG
AAGGCGCCGGCACGGTGTCGCTGAAGCTTGCCCGCCGCCCGGACGGCATCTGCCTTTCGGTCGCCGACCATGGTCCGGGT
GTCCCGGCCGAACGGCGCGACGACGTGGTGAAGCGCTTCGTTCGCCTTGATGAAAGCCGCTCGAAGCCCGGCACCGGGCT
CGGCCTTTCGCTGGTGGAAGCCGTCATGGAGCTGCACAATGGCCGGCTGGAGCTCTCGGACACCGATCCCGACAAGCCCG
AACAGCGCGGCTTGACCGTCAGCATGATCTTCCCGGCCAAGGCGGCGTGA

Upstream 100 bases:

>100_bases
ACGTCCACGTCTCGCGCCTGCGCTCGAAGATCGAGAAGGACTACAGCCAGCCGCTCCTGAAGACCATCCGGGGCGCGGGG
TACATGATCAAGGACGAGGG

Downstream 100 bases:

>100_bases
TCTTTTCCGCCGAAATCCGATGGGCTGAATCGCGTATTGGCGGTTTGGCGCCAAGACCCTAGTTTAATCCCGACCGAAGG
AGAGAGTTCGCGATTCGACG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSRFRVLFKSTAVRLSALYILLFAICAATLVFYVTAMSERLLTGQIRDAVKQEVEQVQRAYDTGGMNLLLRTMERRARQP
GANLYVIAGPSGDILAGNVASVQPGVFEEIGWTSAPFIYQRYTDSGVERRHKAIANIFVLDNGLRILIGRDLGDPERFRL
LVRQALMVALAIMGLGAIIIWFAIGRNALKRIDRMSDASKKIMAGDLSQRLPVGGSGDEFDRLSMSLNTMLERIEKLNEG
LRQVSDNIAHDLKTPLTRLRNKAADALDIADGETRRTALEGIISESDQLIRTFNALLMISRVEAGSVAAEMSPVELSAIV
SDSAELYEPAAEEAGLDLSASVEPGVEVQGNRELIGQAIFNLLDNAIKYSADTEGAGTVSLKLARRPDGICLSVADHGPG
VPAERRDDVVKRFVRLDESRSKPGTGLGLSLVEAVMELHNGRLELSDTDPDKPEQRGLTVSMIFPAKAA

Sequences:

>Translated_469_residues
MSRFRVLFKSTAVRLSALYILLFAICAATLVFYVTAMSERLLTGQIRDAVKQEVEQVQRAYDTGGMNLLLRTMERRARQP
GANLYVIAGPSGDILAGNVASVQPGVFEEIGWTSAPFIYQRYTDSGVERRHKAIANIFVLDNGLRILIGRDLGDPERFRL
LVRQALMVALAIMGLGAIIIWFAIGRNALKRIDRMSDASKKIMAGDLSQRLPVGGSGDEFDRLSMSLNTMLERIEKLNEG
LRQVSDNIAHDLKTPLTRLRNKAADALDIADGETRRTALEGIISESDQLIRTFNALLMISRVEAGSVAAEMSPVELSAIV
SDSAELYEPAAEEAGLDLSASVEPGVEVQGNRELIGQAIFNLLDNAIKYSADTEGAGTVSLKLARRPDGICLSVADHGPG
VPAERRDDVVKRFVRLDESRSKPGTGLGLSLVEAVMELHNGRLELSDTDPDKPEQRGLTVSMIFPAKAA
>Mature_468_residues
SRFRVLFKSTAVRLSALYILLFAICAATLVFYVTAMSERLLTGQIRDAVKQEVEQVQRAYDTGGMNLLLRTMERRARQPG
ANLYVIAGPSGDILAGNVASVQPGVFEEIGWTSAPFIYQRYTDSGVERRHKAIANIFVLDNGLRILIGRDLGDPERFRLL
VRQALMVALAIMGLGAIIIWFAIGRNALKRIDRMSDASKKIMAGDLSQRLPVGGSGDEFDRLSMSLNTMLERIEKLNEGL
RQVSDNIAHDLKTPLTRLRNKAADALDIADGETRRTALEGIISESDQLIRTFNALLMISRVEAGSVAAEMSPVELSAIVS
DSAELYEPAAEEAGLDLSASVEPGVEVQGNRELIGQAIFNLLDNAIKYSADTEGAGTVSLKLARRPDGICLSVADHGPGV
PAERRDDVVKRFVRLDESRSKPGTGLGLSLVEAVMELHNGRLELSDTDPDKPEQRGLTVSMIFPAKAA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=28.6259541984733, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789808, Length=236, Percent_Identity=30.9322033898305, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=258, Percent_Identity=26.7441860465116, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786783, Length=309, Percent_Identity=24.5954692556634, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=26.8181818181818, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=25.390625, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=24.7422680412371, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=26.5993265993266, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=346, Percent_Identity=26.3005780346821, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=230, Percent_Identity=24.3478260869565, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=199, Percent_Identity=26.6331658291457, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=26.4462809917355, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51119; Mature: 50988

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFRVLFKSTAVRLSALYILLFAICAATLVFYVTAMSERLLTGQIRDAVKQEVEQVQRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDTGGMNLLLRTMERRARQPGANLYVIAGPSGDILAGNVASVQPGVFEEIGWTSAPFIYQ
HCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCHHHHCCCCCCCHHHH
RYTDSGVERRHKAIANIFVLDNGLRILIGRDLGDPERFRLLVRQALMVALAIMGLGAIII
HHHHHHHHHHHHHHHHEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WFAIGRNALKRIDRMSDASKKIMAGDLSQRLPVGGSGDEFDRLSMSLNTMLERIEKLNEG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRQVSDNIAHDLKTPLTRLRNKAADALDIADGETRRTALEGIISESDQLIRTFNALLMIS
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVEAGSVAAEMSPVELSAIVSDSAELYEPAAEEAGLDLSASVEPGVEVQGNRELIGQAIF
HCCCCCHHHHCCCHHHHHHHHCCHHHHCCHHHHCCCCCCCCCCCCCEECCCHHHHHHHHH
NLLDNAIKYSADTEGAGTVSLKLARRPDGICLSVADHGPGVPAERRDDVVKRFVRLDESR
HHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
SKPGTGLGLSLVEAVMELHNGRLELSDTDPDKPEQRGLTVSMIFPAKAA
CCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHCCCEEEEECCCCCC
>Mature Secondary Structure 
SRFRVLFKSTAVRLSALYILLFAICAATLVFYVTAMSERLLTGQIRDAVKQEVEQVQRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDTGGMNLLLRTMERRARQPGANLYVIAGPSGDILAGNVASVQPGVFEEIGWTSAPFIYQ
HCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCHHHHCCCCCCCHHHH
RYTDSGVERRHKAIANIFVLDNGLRILIGRDLGDPERFRLLVRQALMVALAIMGLGAIII
HHHHHHHHHHHHHHHHEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WFAIGRNALKRIDRMSDASKKIMAGDLSQRLPVGGSGDEFDRLSMSLNTMLERIEKLNEG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRQVSDNIAHDLKTPLTRLRNKAADALDIADGETRRTALEGIISESDQLIRTFNALLMIS
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVEAGSVAAEMSPVELSAIVSDSAELYEPAAEEAGLDLSASVEPGVEVQGNRELIGQAIF
HCCCCCHHHHCCCHHHHHHHHCCHHHHCCHHHHCCCCCCCCCCCCCEECCCHHHHHHHHH
NLLDNAIKYSADTEGAGTVSLKLARRPDGICLSVADHGPGVPAERRDDVVKRFVRLDESR
HHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
SKPGTGLGLSLVEAVMELHNGRLELSDTDPDKPEQRGLTVSMIFPAKAA
CCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA