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The map label for this gene is fmt [H]

Identifier: 209547670

GI number: 209547670

Start: 58841

End: 59776

Strand: Direct

Name: fmt [H]

Synonym: Rleg2_0058

Alternate gene names: 209547670

Gene position: 58841-59776 (Clockwise)

Preceding gene: 209547669

Following gene: 209547671

Centisome position: 1.3

GC content: 66.03

Gene sequence:

>936_bases
ATGTCGCTTAGCATCATTTTCATGGGAACCCCCGAGTTCTCGGTTCCGACCCTGCGCCTGCTCGTCGATGCCGGGCACAG
GATCGTCGCCGTCTACACGCAGCCGCCGCGGCCGGGCGGGCGGCGCGGGCTCGATCTGCAGAAATCGCCGGTGCATCAGG
CGGCCGAGCTGCTCGGCCTGCCGGTCTTCACACCGGTCAATTTCAAAGATCCCGAGGAGCGCGAGAGGTTTGCCGCCCTC
AAGGCCGATGTCGCCGTCGTCGTTGCGTATGGATTGCTGCTGCCGGAGGCGGTTTTGAACGGCACCCGCGACGGCTGCTA
TAACGGCCACGCCTCGCTGCTGCCCCGCTGGCGGGGTGCAGCACCCATCCAGCGGGCGATCATGGCGGGTGATGCTGAAA
CCGGTATGATGGTGATGAAGATGGACAAGGGCCTCGATACCGGCGCCGTGGCGCTGACCCGAAAAGTCGAGATCGGCCCG
AACATGACGGCAGGCGAGCTGCACGACCGGCTGATGCAGGTCGGCGCCAAGGCGATGGCCGAAGCCATGGTGAAGCTGGA
AATGAACGACCTGCCGCTGACGCCGCAGCCGCAAGACGGCGTGCTCTATGCCGCCAAGATCGACAAGGCCGAAACCCGCA
TCGATTTCGCCAGGCCTGCCCTGGATGTGCACAATCATATCCGCGGTCTGGCGCCATTTCCCGGCGCCTGGTTCGAACTC
GAGATCGGCGGCAAGCCTGAGCGCGTGAAGGTGCTGGGATCCGAGCTGGCTGAGGGGCAGGGTGCCGCCGGAGAGCTGCT
GACCGATGATCTCGTGGTCGCCTGCGCCTCGGGTGCTGTGCGGCTGACCAGGCTGCAGAAGGCAGGCGGCAAGCCGCTGG
CGGCGGCCGATTTCCTCAGGGGCACGCCGCTTGCCGCCGGCATGAGGCTTTCCTGA

Upstream 100 bases:

>100_bases
GCGCCACACTCGCGACCCGCAACACCAGAGATTTCGAGGGGCTTGATCTCAAGCTCGTAAACCCGTTTGAAGACGGCTGA
TCCTCAATTGGCGAGATAGA

Downstream 100 bases:

>100_bases
TGCCGCGTTTCCGCATGACGGTCGAATATGACGGCGGCCCCTATGTCGGCTGGCAGAGGCAGGAGAATGGCCCCTCGGTG
CAGGGCGCGATCGAAGCCGC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGLPVFTPVNFKDPEERERFAAL
KADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGAAPIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGP
NMTAGELHDRLMQVGAKAMAEAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFEL
EIGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLRGTPLAAGMRLS

Sequences:

>Translated_311_residues
MSLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGLPVFTPVNFKDPEERERFAAL
KADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGAAPIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGP
NMTAGELHDRLMQVGAKAMAEAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFEL
EIGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLRGTPLAAGMRLS
>Mature_310_residues
SLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGLPVFTPVNFKDPEERERFAALK
ADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGAAPIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGPN
MTAGELHDRLMQVGAKAMAEAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFELE
IGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLRGTPLAAGMRLS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=243, Percent_Identity=31.2757201646091, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI238814322, Length=316, Percent_Identity=30.379746835443, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI164663775, Length=321, Percent_Identity=28.6604361370716, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789683, Length=305, Percent_Identity=44.2622950819672, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI1788589, Length=293, Percent_Identity=26.6211604095563, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI133930964, Length=268, Percent_Identity=29.1044776119403, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=281, Percent_Identity=26.6903914590747, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550868, Length=314, Percent_Identity=31.2101910828025, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571984, Length=229, Percent_Identity=33.6244541484716, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585660, Length=322, Percent_Identity=27.3291925465839, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33166; Mature: 33035

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGL
CCEEEEEEECCCCCCCHHEEEEECCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
PVFTPVNFKDPEERERFAALKADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
APIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGPNMTAGELHDRLMQVGAKAMA
CHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
EAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFEL
HHHHHEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
EIGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLR
EECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHCCCCCCHHHHHHC
GTPLAAGMRLS
CCCCCCCCCCC
>Mature Secondary Structure 
SLSIIFMGTPEFSVPTLRLLVDAGHRIVAVYTQPPRPGGRRGLDLQKSPVHQAAELLGL
CEEEEEEECCCCCCCHHEEEEECCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
PVFTPVNFKDPEERERFAALKADVAVVVAYGLLLPEAVLNGTRDGCYNGHASLLPRWRGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
APIQRAIMAGDAETGMMVMKMDKGLDTGAVALTRKVEIGPNMTAGELHDRLMQVGAKAMA
CHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
EAMVKLEMNDLPLTPQPQDGVLYAAKIDKAETRIDFARPALDVHNHIRGLAPFPGAWFEL
HHHHHEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
EIGGKPERVKVLGSELAEGQGAAGELLTDDLVVACASGAVRLTRLQKAGGKPLAAADFLR
EECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHCCCCCCHHHHHHC
GTPLAAGMRLS
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA