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The map label for this gene is pgi [H]

Identifier: 209399227

GI number: 209399227

Start: 5151372

End: 5153021

Strand: Direct

Name: pgi [H]

Synonym: ECH74115_5504

Alternate gene names: 209399227

Gene position: 5151372-5153021 (Clockwise)

Preceding gene: 209400390

Following gene: 209396054

Centisome position: 92.45

GC content: 51.45

Gene sequence:

>1650_bases
ATGAAAAACATCAATCCAACGCAGACCGCTGCCTGGCAGGCACTACAGAAACACTTCGATGAAATGAAAGACGTTACGAT
CGCCGATCTTTTTGCTAAAGACGGCGATCGTTTTTCTAAGTTCTCCGCAACCTTCGACGATCAGATGCTGGTGGATTACT
CCAAAAACCGCATCACTGAAGAGACGCTGGCGAAATTACAAGATCTGGCGAAAGAGTGCGATCTGGCGGGCGCGATTAAG
TCGATGTTCTCTGGCGAGAAGATCAACCGCACTGAAAACCGCGCCGTGCTGCACGTAGCGCTGCGTAATCGTAGCAATAC
CCCGATTCTGGTTGATGGCAAAGATGTTATGCCAGAAGTCAACGCGGTGCTGGAGAAGATGAAAACCTTCTCGGAAGCGA
TTATCTCCGGTGAGTGGAAGGGTTATACCGGCAAAGCAATCACTGACGTAGTGAACATCGGGATCGGCGGTTCTGACCTC
GGCCCGTACATGGTGACCGAAGCACTGCGTCCGTACAAAAATCACCTGAACATGCACTTTGTTTCTAACGTCGATGGGAC
TCACATCGCTGAAGTGCTGAAAAAAGTAAACCCGGAAACCACGCTGTTCCTGGTAGCATCTAAAACCTTCACCACTCAGG
AAACCATGACCAACGCCCATAGCGCGCGTGACTGGTTCCTGAAAGCGGCAGGTGATGAAAAACACGTTGCGAAACACTTT
GCGGCGCTCTCAACCAATGCCAAAGCCGTTGGCGAGTTTGGTATTGATACTGCCAACATGTTCGAGTTCTGGGACTGGGT
CGGCGGTCGTTACTCTTTGTGGTCAGCGATTGGCCTGTCGATTGTTCTCTCCATCGGCTTTGATAACTTCGTTGAACTGC
TTTCTGGCGCACACGCGATGGACAAGCATTTCTCCACCACGCCTGCCGAGAAAAACCTGCCTGTACTGTTGGCGCTGATT
GGCATCTGGTACAACAATTTCTTTGGTGCGGAAACTGAAGCGATTCTGCCGTATGACCAGTATATGCACCGTTTCGCGGC
GTACTTCCAGCAGGGCAATATGGAGTCCAACGGTAAGTATGTTGACCGTAACGGTAACGTTGTGGATTACCAGACTGGCC
CGATTATCTGGGGTGAACCAGGCACTAACGGTCAGCACGCGTTCTACCAGCTGATCCACCAGGGAACCAAAATGGTACCG
TGCGATTTCATCGCTCCGGCTATCACCCATAACCCGCTCTCTGATCACCACCAGAAACTGCTGTCTAACTTCTTCGCCCA
GACCGAAGCGCTGGCGTTTGGTAAATCCCGCGAAGTGGTTGAGCAGGAATATCGCGATCAGGGTAAAGATCCGGCAACGC
TTGACTACGTGGTGCCGTTCAAAGTGTTCGAAGGTAACCGCCCGACCAACTCTATCCTGTTGCGCGAAATCACTCCGTTC
AGCCTGGGTGCGTTGATTGCGCTGTATGAGCACAAAATCTTTACTCAGGGCGTGATCCTGAACATCTTCACCTTCGACCA
GTGGGGCGTGGAACTGGGTAAACAGCTGGCGAACCGTATTCTGCCAGAGCTGAAAGATGATAAAGAAATCAGCAGCCACG
ATAGCTCGACCAATGGTCTGATTAACCGCTATAAAGCGTGGCGCGGTTAA

Upstream 100 bases:

>100_bases
CTCAACATTACGCTAACGGCACTAAAACCATCACATTTTTCTGTGACTGGCGCTACAATCTTCCAAAGTCACAATTCTCA
AAATCAGAAGAGTATTGCTA

Downstream 100 bases:

>100_bases
TCATCGTTCATGCCTGATGCCGCTATGTAGGCCGGATAAGGCGTTTACGCCGCATCCGGCAACTGGTGCCTGATGCGACG
CTTTACGCGTCTTATCAGGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Sequences:

>Translated_549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
>Mature_549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=549, Percent_Identity=64.8451730418944, Blast_Score=740, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=549, Percent_Identity=60.8378870673953, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=100, Blast_Score=1144, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=64.4688644688645, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=64.8798521256932, Blast_Score=722, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=59.3806921675774, Blast_Score=655, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=65.7559198542805, Blast_Score=733, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=65.7559198542805, Blast_Score=733, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=65.7559198542805, Blast_Score=733, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61530; Mature: 61530

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCCCCHHHCCHHHCCCH
ETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
EECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHH
INRYKAWRG
HHHHHHCCC
>Mature Secondary Structure
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCCCCHHHCCHHHCCCH
ETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
EECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHH
INRYKAWRG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA