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The map label for this gene is folE [H]

Identifier: 20808735

GI number: 20808735

Start: 2260745

End: 2261311

Strand: Reverse

Name: folE [H]

Synonym: TTE2371

Alternate gene names: 20808735

Gene position: 2261311-2260745 (Counterclockwise)

Preceding gene: 20808736

Following gene: 20808734

Centisome position: 84.08

GC content: 42.5

Gene sequence:

>567_bases
ATGATAGACAAAGAAAAGATTAAAAAAGCTGTAAGAGAGATACTTGAAGCCATAGGCGAAGACCCCGATAGGGAGGGGCT
CCTTGAGACTCCTGACAGAGTAGCCAGGATGTACGAAGAAATTTTTTCTGGACTTCACACAGATGTAAAAGACGTTATAA
AAATTTTCCAAGAAGATGAGCATCAAGAGATAATCCTGGTAAAAGATATTCCCCTTTACTCTATGTGTGAGCATCATCTT
CTTCCTTTTATAGGTGTTGCCCATGTGGCATACCTTCCAAGAAAAGGGCGAATTTTAGGCCTTTCAAAAGTTGCTCGTAT
AGTAGACGTTTTATCAAAAAGGCCTCAGCTCCAAGAAAGGCTCACTAGTGAAATTGCGGATACCATAATGGAAGCCGTCA
ATCCTTTGGGAGTTGCTGTTGTCATAGAGGCAGAGCATCTGTGCATGACTATGAGGGGGGTTAAAAAGCCGGGCTCTAAA
ACTGTTACCTCTGCCCTAAGGGGAATATTTAGAACGGACCAGAAAGCCAGAGCGGAAGTGATGGCTTTGATAAATTCCAA
GAGATAG

Upstream 100 bases:

>100_bases
AGCAGTCGCAGGACTGCTTTTAACTTTTATATGCTGGCTTTTTTTCGCAAAAAGTAATATAATTAAAGCTGTGCACAACA
AAAAAGAAGGGGTATCAAAA

Downstream 100 bases:

>100_bases
GGGGAAGGCTATGATTTTAAAGTGCAGGGATAAGACTTTAGAGATTGGCAAAAGGACCTACATAATGGGTATTTTGAACA
TGACTCCTGATTCCTTTTCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIDKEKIKKAVREILEAIGEDPDREGLLETPDRVARMYEEIFSGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKVARIVDVLSKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGVKKPGSK
TVTSALRGIFRTDQKARAEVMALINSKR

Sequences:

>Translated_188_residues
MIDKEKIKKAVREILEAIGEDPDREGLLETPDRVARMYEEIFSGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKVARIVDVLSKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGVKKPGSK
TVTSALRGIFRTDQKARAEVMALINSKR
>Mature_188_residues
MIDKEKIKKAVREILEAIGEDPDREGLLETPDRVARMYEEIFSGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKVARIVDVLSKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGVKKPGSK
TVTSALRGIFRTDQKARAEVMALINSKR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=183, Percent_Identity=51.9125683060109, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI4503949, Length=183, Percent_Identity=51.9125683060109, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI66932970, Length=141, Percent_Identity=50.354609929078, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI66932972, Length=141, Percent_Identity=50.354609929078, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1788476, Length=180, Percent_Identity=39.4444444444444, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560486, Length=181, Percent_Identity=48.0662983425414, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321706, Length=186, Percent_Identity=46.7741935483871, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24656782, Length=183, Percent_Identity=50.2732240437158, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24656796, Length=183, Percent_Identity=50.2732240437158, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24656791, Length=183, Percent_Identity=50.2732240437158, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21219; Mature: 21219

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKEKIKKAVREILEAIGEDPDREGLLETPDRVARMYEEIFSGLHTDVKDVIKIFQEDE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
HQEIILVKDIPLYSMCEHHLLPFIGVAHVAYLPRKGRILGLSKVARIVDVLSKRPQLQER
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCHHHHHH
LTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGVKKPGSKTVTSALRGIFRTDQKARAEV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHH
MALINSKR
HHHHHCCC
>Mature Secondary Structure
MIDKEKIKKAVREILEAIGEDPDREGLLETPDRVARMYEEIFSGLHTDVKDVIKIFQEDE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
HQEIILVKDIPLYSMCEHHLLPFIGVAHVAYLPRKGRILGLSKVARIVDVLSKRPQLQER
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCHHHHHH
LTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGVKKPGSKTVTSALRGIFRTDQKARAEV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHH
MALINSKR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA