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The map label for this gene is lysS [H]

Identifier: 20808736

GI number: 20808736

Start: 2261413

End: 2262912

Strand: Reverse

Name: lysS [H]

Synonym: TTE2372

Alternate gene names: 20808736

Gene position: 2262912-2261413 (Counterclockwise)

Preceding gene: 20808737

Following gene: 20808735

Centisome position: 84.14

GC content: 39.07

Gene sequence:

>1500_bases
ATGAGTAATTCTAATGAGAACATTTTGAATGACCTTGAGAATTTGAATGAACTTTTAAGGGTGAGAAGAGAGAAACTCAA
TATCTTAAGGAGCATGGGGATAGAGCCCTATGGCATAGATAGGTTTGAAAGAACTAATCTTTCCTCAGACATTAAAAACG
ATTACGAAAATTTTGAAGGGAAAACTGTAACTCTAGCAGGAAGGATAATGACCAAGAGGAGCCACGGAAAAGCTTCTTTT
GCAGATATACAGGACAGGGACGGAAGAATTCAAATTTATGTGAGATATGATAATGTCGGAGGAAAAAACTACGAAATCTT
TAAGCTCCTTGACATAGGTGATATTATAGGGGTTACAGGAGAAGTCTTTAAGACAAAGACCGGAGAAATTACTATAAACG
TGAAAGACTTTAAGCTTTTATGCAAGTCACTGCAAGTTCTCCCTGAAAAGTGGCATGGTTTAAAAGACCCGGATTTAAGG
TATAGGCAAAGATACGTAGACCTAATAATAAATCCAAGCGTAAGGGAAGTATTCTTAAAAAGGACCAAGATAATAAAAGC
AATAAGAGAATTTTTAGACAATAGAGGATTTCTGGAAGTTGAAACTCCAGTTTTGCACACAATCGCAGGTGGAGCAGCGG
CAAGGCCCTTTATCACCCATCACAACGCTTTAGACATAGACATGTATTTACGAATTGCGCTGGAGCTTCACTTGAAGAGG
TTAATTGTCGGGGGATTTGAAAAGGTCTATGAAATAGGCAGAGTCTTTAGAAATGAGGGAATGGATATAAGGCACAATCC
GGAGTTTACACTCCTGGAACTTTATGAAGCTTATACGGATTATCACGGTATGATGGAACTTACTGAACAGCTTTTTGCGT
ATGTGGCTGAAAAAGTAAATGGCAGCACAAAAATAATCTATCAGGGCACTGAAATAGATTTGACGCCGCCGTGGAAGAGA
ATCACCATGGTGGATGCTATAAAAGAATATGTGGGGATTGACTTTGAAAAAGTTGCTACAGATGAAGAAGCGAGAAAAAT
AGCAAAGGATTTAAATCTGGAGTTGAAAAAGCCTGATATGAAAAAAGGAGAAGTAATAGCACTTGTTTTTGACGAACTGG
TAGAAAAGCACCTTATACAGCCTACTTTTGTCATGGACTATCCAGTGGAGGTTTCTCCTTTGGCTAAAAGAAAGCGCGAC
AACCCTGCTTTTACTTCCAGGTTTGAAGCTTTCATTTACGGCAGAGAAGTTGCAAACGCATTTTCAGAGCTAAATGACCC
GATTGACCAGAAAGAGAGATTTTTGGAACAGTTAAGGCAGAGAGAAGCGGGAGATGAAGAAGCTCACATGATGGATGAGG
ACTTTATAAATGCCCTTGAGGTAGGTATGCCACCTACAGGAGGTTTGGGTATAGGTGTAGACAGGCTTGTCATGTTTATG
ACAGATTCTTATTCTATAAGGGATGTAATACTCTTCCCTACAATGAAACCCAAAGATTAA

Upstream 100 bases:

>100_bases
GGCAAAAAGGTTGGAGAAACAATTTCTGTAGAAGTGCCTGCGGGAGTTATTAAACTCAAAATACTCGAAATACGAAGGTA
AAGGGTGATGGAGGTATAAT

Downstream 100 bases:

>100_bases
AAGCAGTCGCAGGACTGCTTTTAACTTTTATATGCTGGCTTTTTTTCGCAAAAAGTAATATAATTAAAGCTGTGCACAAC
AAAAAAGAAGGGGTATCAAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSNSNENILNDLENLNELLRVRREKLNILRSMGIEPYGIDRFERTNLSSDIKNDYENFEGKTVTLAGRIMTKRSHGKASF
ADIQDRDGRIQIYVRYDNVGGKNYEIFKLLDIGDIIGVTGEVFKTKTGEITINVKDFKLLCKSLQVLPEKWHGLKDPDLR
YRQRYVDLIINPSVREVFLKRTKIIKAIREFLDNRGFLEVETPVLHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
LIVGGFEKVYEIGRVFRNEGMDIRHNPEFTLLELYEAYTDYHGMMELTEQLFAYVAEKVNGSTKIIYQGTEIDLTPPWKR
ITMVDAIKEYVGIDFEKVATDEEARKIAKDLNLELKKPDMKKGEVIALVFDELVEKHLIQPTFVMDYPVEVSPLAKRKRD
NPAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLRQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFM
TDSYSIRDVILFPTMKPKD

Sequences:

>Translated_499_residues
MSNSNENILNDLENLNELLRVRREKLNILRSMGIEPYGIDRFERTNLSSDIKNDYENFEGKTVTLAGRIMTKRSHGKASF
ADIQDRDGRIQIYVRYDNVGGKNYEIFKLLDIGDIIGVTGEVFKTKTGEITINVKDFKLLCKSLQVLPEKWHGLKDPDLR
YRQRYVDLIINPSVREVFLKRTKIIKAIREFLDNRGFLEVETPVLHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
LIVGGFEKVYEIGRVFRNEGMDIRHNPEFTLLELYEAYTDYHGMMELTEQLFAYVAEKVNGSTKIIYQGTEIDLTPPWKR
ITMVDAIKEYVGIDFEKVATDEEARKIAKDLNLELKKPDMKKGEVIALVFDELVEKHLIQPTFVMDYPVEVSPLAKRKRD
NPAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLRQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFM
TDSYSIRDVILFPTMKPKD
>Mature_498_residues
SNSNENILNDLENLNELLRVRREKLNILRSMGIEPYGIDRFERTNLSSDIKNDYENFEGKTVTLAGRIMTKRSHGKASFA
DIQDRDGRIQIYVRYDNVGGKNYEIFKLLDIGDIIGVTGEVFKTKTGEITINVKDFKLLCKSLQVLPEKWHGLKDPDLRY
RQRYVDLIINPSVREVFLKRTKIIKAIREFLDNRGFLEVETPVLHTIAGGAAARPFITHHNALDIDMYLRIALELHLKRL
IVGGFEKVYEIGRVFRNEGMDIRHNPEFTLLELYEAYTDYHGMMELTEQLFAYVAEKVNGSTKIIYQGTEIDLTPPWKRI
TMVDAIKEYVGIDFEKVATDEEARKIAKDLNLELKKPDMKKGEVIALVFDELVEKHLIQPTFVMDYPVEVSPLAKRKRDN
PAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLRQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMT
DSYSIRDVILFPTMKPKD

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=506, Percent_Identity=43.0830039525692, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI194272210, Length=506, Percent_Identity=43.0830039525692, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI45439306, Length=472, Percent_Identity=23.5169491525424, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI40789249, Length=263, Percent_Identity=28.1368821292776, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI226491502, Length=464, Percent_Identity=23.2758620689655, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790571, Length=511, Percent_Identity=50.880626223092, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789256, Length=507, Percent_Identity=50.4930966469428, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI87082379, Length=323, Percent_Identity=32.1981424148607, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788173, Length=252, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17535925, Length=515, Percent_Identity=42.9126213592233, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17535927, Length=515, Percent_Identity=42.9126213592233, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71994340, Length=503, Percent_Identity=43.7375745526839, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17551876, Length=478, Percent_Identity=23.2217573221757, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32566633, Length=304, Percent_Identity=25.6578947368421, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=467, Percent_Identity=45.3961456102784, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=33.6820083682008, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323011, Length=360, Percent_Identity=25.8333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=300, Percent_Identity=24.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640849, Length=508, Percent_Identity=42.9133858267717, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24640851, Length=508, Percent_Identity=42.9133858267717, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17136276, Length=468, Percent_Identity=22.4358974358974, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57589; Mature: 57458

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSNENILNDLENLNELLRVRREKLNILRSMGIEPYGIDRFERTNLSSDIKNDYENFEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
KTVTLAGRIMTKRSHGKASFADIQDRDGRIQIYVRYDNVGGKNYEIFKLLDIGDIIGVTG
CEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEHHHHHCCCC
EVFKTKTGEITINVKDFKLLCKSLQVLPEKWHGLKDPDLRYRQRYVDLIINPSVREVFLK
HHHEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCHHHHHHHH
RTKIIKAIREFLDNRGFLEVETPVLHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
HHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LIVGGFEKVYEIGRVFRNEGMDIRHNPEFTLLELYEAYTDYHGMMELTEQLFAYVAEKVN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSTKIIYQGTEIDLTPPWKRITMVDAIKEYVGIDFEKVATDEEARKIAKDLNLELKKPDM
CCEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCEECCCCC
KKGEVIALVFDELVEKHLIQPTFVMDYPVEVSPLAKRKRDNPAFTSRFEAFIYGREVANA
CCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FSELNDPIDQKERFLEQLRQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFM
HHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
TDSYSIRDVILFPTMKPKD
CCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SNSNENILNDLENLNELLRVRREKLNILRSMGIEPYGIDRFERTNLSSDIKNDYENFEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
KTVTLAGRIMTKRSHGKASFADIQDRDGRIQIYVRYDNVGGKNYEIFKLLDIGDIIGVTG
CEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEHHHHHCCCC
EVFKTKTGEITINVKDFKLLCKSLQVLPEKWHGLKDPDLRYRQRYVDLIINPSVREVFLK
HHHEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCHHHHHHHH
RTKIIKAIREFLDNRGFLEVETPVLHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
HHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LIVGGFEKVYEIGRVFRNEGMDIRHNPEFTLLELYEAYTDYHGMMELTEQLFAYVAEKVN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSTKIIYQGTEIDLTPPWKRITMVDAIKEYVGIDFEKVATDEEARKIAKDLNLELKKPDM
CCEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCEECCCCC
KKGEVIALVFDELVEKHLIQPTFVMDYPVEVSPLAKRKRDNPAFTSRFEAFIYGREVANA
CCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FSELNDPIDQKERFLEQLRQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFM
HHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
TDSYSIRDVILFPTMKPKD
CCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA