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The map label for this gene is FolP [C]

Identifier: 20808734

GI number: 20808734

Start: 2259922

End: 2260734

Strand: Reverse

Name: FolP [C]

Synonym: TTE2370

Alternate gene names: 20808734

Gene position: 2260734-2259922 (Counterclockwise)

Preceding gene: 20808735

Following gene: 20808733

Centisome position: 84.06

GC content: 41.08

Gene sequence:

>813_bases
ATGATTTTAAAGTGCAGGGATAAGACTTTAGAGATTGGCAAAAGGACCTACATAATGGGTATTTTGAACATGACTCCTGA
TTCCTTTTCAGACGGAGGCAAATACAATACTTTGGAAAAAGGGATTGAAAGAGCTTTGCAGATGATTGAAGAGGGAGCAG
ATATAATAGATGTAGGAGGAGAGTCTACAAGGCCCGGATACACTCCTGTCGATGAAGAGGAAGAAATTAGAAGGGTTATA
CCTGTAATCGAAAGGCTTTCTAAAATTTCAGATGTGATAATTTCTGTGGATACTATGAAGGCGAATGTAGCTTTAAGGGC
GCTGGAGGCAGGAGCCCATATAGTAAATGATGTGTGGGGGCTTCAGAGAGACCCCAAGATGGCAGAAGTAGTTGCCAAAT
ATAAAGCAGGGGTTGTCATGATGCACAACAGCAATGTGGCTGAGTACGGCGATGTAGTAAAATCTATCATAGAATTTTTG
AAAAAGAGCATAGAAATTGCTGAGAAAGCTGGAATTGAAAGAAACCAGATGATAGTTGACCCTGGCATAGGCTTTGGAAA
GACTTTAGAGCATAATTTGGAAGTCATGAATCGCCTGGAGGAATTAAAAGTTCTGGGACTTCCTGTCCTTTTGGGTACTT
CCAGAAAATCTATGATAGGCAAAGTCTTAAACGTAGATGTAGAGGATAGATTGGAGGGGACAGCGGCGACTGTAGCTGTG
GGAATAGTAAAAGGAGTGGATATAATAAGAGTCCACGATGTAAAAGAGATGTCAAGAGTAGCTAAAATGACTGATGCGAT
GGTGAGAAGATGA

Upstream 100 bases:

>100_bases
AAAACTGTTACCTCTGCCCTAAGGGGAATATTTAGAACGGACCAGAAAGCCAGAGCGGAAGTGATGGCTTTGATAAATTC
CAAGAGATAGGGGGAAGGCT

Downstream 100 bases:

>100_bases
CAGAGGTATACCTTTCTTTGGGTTCAAATTTAGGAGATAGAGAAAAGTATTTAAAAGAGGCGGTCAAAAGGCTTAAGTCA
AATAAAAACATAGTTTTAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MILKCRDKTLEIGKRTYIMGILNMTPDSFSDGGKYNTLEKGIERALQMIEEGADIIDVGGESTRPGYTPVDEEEEIRRVI
PVIERLSKISDVIISVDTMKANVALRALEAGAHIVNDVWGLQRDPKMAEVVAKYKAGVVMMHNSNVAEYGDVVKSIIEFL
KKSIEIAEKAGIERNQMIVDPGIGFGKTLEHNLEVMNRLEELKVLGLPVLLGTSRKSMIGKVLNVDVEDRLEGTAATVAV
GIVKGVDIIRVHDVKEMSRVAKMTDAMVRR

Sequences:

>Translated_270_residues
MILKCRDKTLEIGKRTYIMGILNMTPDSFSDGGKYNTLEKGIERALQMIEEGADIIDVGGESTRPGYTPVDEEEEIRRVI
PVIERLSKISDVIISVDTMKANVALRALEAGAHIVNDVWGLQRDPKMAEVVAKYKAGVVMMHNSNVAEYGDVVKSIIEFL
KKSIEIAEKAGIERNQMIVDPGIGFGKTLEHNLEVMNRLEELKVLGLPVLLGTSRKSMIGKVLNVDVEDRLEGTAATVAV
GIVKGVDIIRVHDVKEMSRVAKMTDAMVRR
>Mature_270_residues
MILKCRDKTLEIGKRTYIMGILNMTPDSFSDGGKYNTLEKGIERALQMIEEGADIIDVGGESTRPGYTPVDEEEEIRRVI
PVIERLSKISDVIISVDTMKANVALRALEAGAHIVNDVWGLQRDPKMAEVVAKYKAGVVMMHNSNVAEYGDVVKSIIEFL
KKSIEIAEKAGIERNQMIVDPGIGFGKTLEHNLEVMNRLEELKVLGLPVLLGTSRKSMIGKVLNVDVEDRLEGTAATVAV
GIVKGVDIIRVHDVKEMSRVAKMTDAMVRR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=275, Percent_Identity=42.5454545454545, Blast_Score=219, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=33.125, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29815; Mature: 29815

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKCRDKTLEIGKRTYIMGILNMTPDSFSDGGKYNTLEKGIERALQMIEEGADIIDVGG
CEEECCCCHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGYTPVDEEEEIRRVIPVIERLSKISDVIISVDTMKANVALRALEAGAHIVNDVWG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQRDPKMAEVVAKYKAGVVMMHNSNVAEYGDVVKSIIEFLKKSIEIAEKAGIERNQMIVD
CCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PGIGFGKTLEHNLEVMNRLEELKVLGLPVLLGTSRKSMIGKVLNVDVEDRLEGTAATVAV
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHCCCHHHHHCCHHHHHHH
GIVKGVDIIRVHDVKEMSRVAKMTDAMVRR
HHHHCCCEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILKCRDKTLEIGKRTYIMGILNMTPDSFSDGGKYNTLEKGIERALQMIEEGADIIDVGG
CEEECCCCHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGYTPVDEEEEIRRVIPVIERLSKISDVIISVDTMKANVALRALEAGAHIVNDVWG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQRDPKMAEVVAKYKAGVVMMHNSNVAEYGDVVKSIIEFLKKSIEIAEKAGIERNQMIVD
CCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PGIGFGKTLEHNLEVMNRLEELKVLGLPVLLGTSRKSMIGKVLNVDVEDRLEGTAATVAV
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHCCCHHHHHCCHHHHHHH
GIVKGVDIIRVHDVKEMSRVAKMTDAMVRR
HHHHCCCEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]