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The map label for this gene is FolK [H]

Identifier: 20808733

GI number: 20808733

Start: 2259425

End: 2259925

Strand: Reverse

Name: FolK [H]

Synonym: TTE2369

Alternate gene names: 20808733

Gene position: 2259925-2259425 (Counterclockwise)

Preceding gene: 20808734

Following gene: 20808732

Centisome position: 84.03

GC content: 37.52

Gene sequence:

>501_bases
ATGACAGAGGTATACCTTTCTTTGGGTTCAAATTTAGGAGATAGAGAAAAGTATTTAAAAGAGGCGGTCAAAAGGCTTAA
GTCAAATAAAAACATAGTTTTAAAGAAGCTCTCTCCCATATATGAGACAAAGCCTGTAGGATATTTAGAACAGGACAATT
TTTTAAACGCTGCAATTTTAATAGAAACAGACCTAACGCCCTATGAACTTCTAGATGTCACTACAAGTATTGAGGCAGAA
CTCAAAAGAGAGCGCACAATAAAATGGGGACCCCGAACCATTGACATAGACATTCTTTTGTATGATGGACTTATTCTAAA
TGATGAGAAGCTAACTATTCCTCATCCTCACATGTGGGAAAGAGCTTTTGTGCTGATACCATTAAGGGATATAAATCCTT
CATTGAGTAAAAACGGTTTATCCATCGATGAGTTGATACAAGGCCTTATAGACAAGCAGGGCGTATGGCTCTACAAAAAG
GATTGGTGTGGAGAGGTGTAA

Upstream 100 bases:

>100_bases
CTGTAGCTGTGGGAATAGTAAAAGGAGTGGATATAATAAGAGTCCACGATGTAAAAGAGATGTCAAGAGTAGCTAAAATG
ACTGATGCGATGGTGAGAAG

Downstream 100 bases:

>100_bases
AAAGTGAGAGTTACAAAAATATTTACCTTTGACAGTGCCCACAACCTTGTTAATTACCATGGGAAATGTGAAGAGTTGCA
CGGCCATACTTATAGGTTAG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTEVYLSLGSNLGDREKYLKEAVKRLKSNKNIVLKKLSPIYETKPVGYLEQDNFLNAAILIETDLTPYELLDVTTSIEAE
LKRERTIKWGPRTIDIDILLYDGLILNDEKLTIPHPHMWERAFVLIPLRDINPSLSKNGLSIDELIQGLIDKQGVWLYKK
DWCGEV

Sequences:

>Translated_166_residues
MTEVYLSLGSNLGDREKYLKEAVKRLKSNKNIVLKKLSPIYETKPVGYLEQDNFLNAAILIETDLTPYELLDVTTSIEAE
LKRERTIKWGPRTIDIDILLYDGLILNDEKLTIPHPHMWERAFVLIPLRDINPSLSKNGLSIDELIQGLIDKQGVWLYKK
DWCGEV
>Mature_165_residues
TEVYLSLGSNLGDREKYLKEAVKRLKSNKNIVLKKLSPIYETKPVGYLEQDNFLNAAILIETDLTPYELLDVTTSIEAEL
KRERTIKWGPRTIDIDILLYDGLILNDEKLTIPHPHMWERAFVLIPLRDINPSLSKNGLSIDELIQGLIDKQGVWLYKKD
WCGEV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=41.1764705882353, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324073, Length=131, Percent_Identity=41.9847328244275, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19139; Mature: 19008

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVYLSLGSNLGDREKYLKEAVKRLKSNKNIVLKKLSPIYETKPVGYLEQDNFLNAAIL
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCEEEEE
IETDLTPYELLDVTTSIEAELKRERTIKWGPRTIDIDILLYDGLILNDEKLTIPHPHMWE
EEECCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEEECCEEECCCEEECCCCCCCC
RAFVLIPLRDINPSLSKNGLSIDELIQGLIDKQGVWLYKKDWCGEV
CEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TEVYLSLGSNLGDREKYLKEAVKRLKSNKNIVLKKLSPIYETKPVGYLEQDNFLNAAIL
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCEEEEE
IETDLTPYELLDVTTSIEAELKRERTIKWGPRTIDIDILLYDGLILNDEKLTIPHPHMWE
EEECCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEEECCEEECCCEEECCCCCCCC
RAFVLIPLRDINPSLSKNGLSIDELIQGLIDKQGVWLYKKDWCGEV
CEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]