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The map label for this gene is glyA [H]

Identifier: 20808520

GI number: 20808520

Start: 2045821

End: 2047062

Strand: Direct

Name: glyA [H]

Synonym: TTE2130

Alternate gene names: 20808520

Gene position: 2045821-2047062 (Clockwise)

Preceding gene: 20808519

Following gene: 20808521

Centisome position: 76.07

GC content: 39.45

Gene sequence:

>1242_bases
ATGGATATTGAAATAATAAGAAAAACAGACCCAGAAATCGCAGAAGTCATATTAAAAGAACTCAACAGACAGAGAAACAA
AATAGAGCTTATAGCCTCTGAAAACTTTGTGAGCAGGGCCGTAATGGAAGCAATGGGTACCCCTCTCACAAATAAATACG
CAGAAGGGTATCCCGGAAGGCGTTATTACGGTGGCTGTGAATATGTAGATATGGCAGAGGAACTTGCAAGGGAAAGGCTT
AAAAAGCTTTTCGGAGCGGAACACGCAAATGTGCAGCCTCACTCGGGAGCTCAGGCAAATATGGCAGCTTATTTTGCACT
TCTAAAACCTGGAGATACTGTACTAGGAATGGATTTAGCTCACGGCGGACATTTAACCCATGGAAGCAAAGTCAATTTTT
CTGGGCAAATATATAACTTTGTATCCTATGGCGTAAGAGAAGATACAGGATACATAGACTATGACCAAGTAGAAGACCTA
GCAAAAAAGCATAAACCAAAACTAATTGTAGCTGGCGCTAGTGCTTATCCAAGAATAATTGACTTTAAGAAATTTAGAGA
AATTGCAGACAAGGTAGGAGCATATCTGATGGTAGACATGGCTCACATTGCCGGGCTTGTCGCAGCAGGTTTACACCCAA
ATCCTGTTCCTTATGCAGACGTAGTGACAACTACTACTCATAAGACTTTAAGAGGACCTAGAGGAGGAGCTATACTCTGT
AAACAAGAACACGCAAAAGCCATCGACAAAGCCCTTTTCCCTGGAACACAAGGTGGACCCTTAATGCATATTATAGCAGC
AAAAGCTGTATGTTTTAAAGAAGCCCTTTCAGATGAGTTTAAAGAATATCAAAAAAGGATTGTAGAAAACGCAAAAGCTT
TAGCAAATGCATTAATGGAAAGAGGAATAAATTTGGTATCCGGCGGTACTGACAACCACTTAATGCTATTAGATTTGCGA
AACACAGGAATAACAGGAAAGGAATTGGAAACTAGATTAGATGAAGTAAACATAACTTGCAATAAAAACGCTATACCTTT
TGATCCATTAGGACCAAATGTAACCTCTGGCGTAAGATTAGGTACACCTGCAGTTACCACCAGAGGAATGAAACCGGAAG
ACATGGTAGAAATAGCAGATATAATAGCTAATATGATAAAAGATGAAAATTACAAAGAAAAAGCGAAAGAAAGGGTAGCA
AAACTACTTGAAAAATACCCTCTCTACCCAGACCTCTTATAA

Upstream 100 bases:

>100_bases
TGATTTTAAATTAAAAGAGTGTTAAATTTTTATTAACTTTGTGTAAAAAATAAATTGTTGTATAATAGAGGTAGAAACAC
AAAAATGAGGGGGTAAAACA

Downstream 100 bases:

>100_bases
CCCCAGACAAGGGGACGGTTCTTCCGTCCGGTTTCTCACAAAAAAATCGGACAAAGAAACCGTCCCCTTGTCCGGTTAAA
AGAGCCTCCTTCTTGGTAAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDIEIIRKTDPEIAEVILKELNRQRNKIELIASENFVSRAVMEAMGTPLTNKYAEGYPGRRYYGGCEYVDMAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALLKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDQVEDL
AKKHKPKLIVAGASAYPRIIDFKKFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KQEHAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALSDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIANMIKDENYKEKAKERVA
KLLEKYPLYPDLL

Sequences:

>Translated_413_residues
MDIEIIRKTDPEIAEVILKELNRQRNKIELIASENFVSRAVMEAMGTPLTNKYAEGYPGRRYYGGCEYVDMAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALLKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDQVEDL
AKKHKPKLIVAGASAYPRIIDFKKFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KQEHAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALSDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIANMIKDENYKEKAKERVA
KLLEKYPLYPDLL
>Mature_413_residues
MDIEIIRKTDPEIAEVILKELNRQRNKIELIASENFVSRAVMEAMGTPLTNKYAEGYPGRRYYGGCEYVDMAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALLKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDQVEDL
AKKHKPKLIVAGASAYPRIIDFKKFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KQEHAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALSDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIANMIKDENYKEKAKERVA
KLLEKYPLYPDLL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=424, Percent_Identity=45.7547169811321, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI261862352, Length=424, Percent_Identity=45.7547169811321, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI261862350, Length=424, Percent_Identity=45.7547169811321, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI261862348, Length=424, Percent_Identity=45.7547169811321, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI22547186, Length=403, Percent_Identity=47.6426799007444, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI261862346, Length=424, Percent_Identity=44.3396226415094, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=46.3917525773196, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1788902, Length=410, Percent_Identity=59.0243902439024, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI25144732, Length=405, Percent_Identity=47.1604938271605, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=405, Percent_Identity=47.1604938271605, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=414, Percent_Identity=47.3429951690821, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6323087, Length=403, Percent_Identity=47.1464019851117, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24640005, Length=401, Percent_Identity=48.6284289276808, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221329721, Length=401, Percent_Identity=48.6284289276808, Blast_Score=391, Evalue=1e-109,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45553; Mature: 45553

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEIIRKTDPEIAEVILKELNRQRNKIELIASENFVSRAVMEAMGTPLTNKYAEGYPGR
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHCCCCCC
RYYGGCEYVDMAEELARERLKKLFGAEHANVQPHSGAQANMAAYFALLKPGDTVLGMDLA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEECCCCCEEEEEEC
HGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDQVEDLAKKHKPKLIVAGASAYPRII
CCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHH
DFKKFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHCCCCCCEEEE
KQEHAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALSDEFKEYQKRIVENAKALANALME
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGINLVSGGTDNHLMLLDLRNTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRL
CCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
GTPAVTTRGMKPEDMVEIADIIANMIKDENYKEKAKERVAKLLEKYPLYPDLL
CCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDIEIIRKTDPEIAEVILKELNRQRNKIELIASENFVSRAVMEAMGTPLTNKYAEGYPGR
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHCCCCCC
RYYGGCEYVDMAEELARERLKKLFGAEHANVQPHSGAQANMAAYFALLKPGDTVLGMDLA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEECCCCCEEEEEEC
HGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDQVEDLAKKHKPKLIVAGASAYPRII
CCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHH
DFKKFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHCCCCCCEEEE
KQEHAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALSDEFKEYQKRIVENAKALANALME
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGINLVSGGTDNHLMLLDLRNTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRL
CCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
GTPAVTTRGMKPEDMVEIADIIANMIKDENYKEKAKERVAKLLEKYPLYPDLL
CCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA