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The map label for this gene is Gnd2 [H]

Identifier: 20808345

GI number: 20808345

Start: 1886540

End: 1887949

Strand: Reverse

Name: Gnd2 [H]

Synonym: TTE1941

Alternate gene names: 20808345

Gene position: 1887949-1886540 (Counterclockwise)

Preceding gene: 20808346

Following gene: 20808344

Centisome position: 70.2

GC content: 35.11

Gene sequence:

>1410_bases
ATGAATGAAATAGGGCTGATTGGCTTAGCAGTTATGGGTCAAAATTTAGCTTTAAACATTGCCAGGAAAGGTTATTCCGT
ATCTGTATTTAACAGAACTTCAGAAAAGACAAAAGAATTCTTAGAAGAAAGAGTAAAAAATGAAAAAATAGAGGGGTATC
ACGATATAAAATCTTTTGTTGAATCTTTAAAAAAACCTAGAAAAATTATACTTATGGTAAAGGCAGGGAAGCCTGTAGAT
GATGTTATACAGGAGCTTCTGCCCTATCTTGAAAAAGGTGACCTTATCATTGATGGGGGCAATTCCTATTTTAAAGATAC
TTCAAGGCGTATAAAAGAATTAAAAGAAAAAGGCATACTCTATTTAGGAATGGGAGTATCGGGAGGAGAGGCAGGAGCAT
TGCACGGTCCTTCATTAATGCCTGGAGGAAGTATTGAGGCTTATGAAATGGTAAAAGATGTTCTTTTAAAGATTGCAGCA
CAGACAGAATCAGGTCCTTGCTGTACATATGTAGGAAATGACTCAGCAGGACATTTTGTTAAAATGGTTCACAATGGAAT
AGAATATGCCATAATGCAGGCAATATCTGAAGTTTACGATATAATGAGAAAAATTTTAAAGTTTTCTCCTGAAGAGATAG
GAGATGTATTTGAAAGATGGAATAATGGAGAATTGAACTCTTTCCTAATGGAGATATCCTTCAAGATTATGAGATATAAG
GATGAAGAGACAGGAAAACATCTTGTAGATTTGATATTGGATGAAGCAGAACAAAAAGGTACAGGAAAATGGACTTCTCA
GACTGCACTGGATTTAGGAATACCAACTCCCTCACTGAGCCTTGCTGTGGAGGCAAGGAGTTTGTCATTCTTTAAAGAAG
ATAGAGTAAAACTTTCAGGGAAAGTTAAAAAAACATATCCTGATGTAAAATTGGATAAAGAAAAAGTGATAAAAGACTTA
GAAAATGCCCTTTTATTTAGCGTATTCACCTCCTTTTCTCAAGGGTTGTGGCTTATACATGAGGCCTCAAAAACTTTTGA
GTACAATATTGACCTTCCAGAGGTATTGCGCATATGGAAGGGCGGCTGTATTATAAGGGCAAAGATTTTAGATTTTTTGA
GAGAAATATTAAATGAAAACAAAGAAAATGTGAACTTGTTAGACAGCGATAAATCTATTTCATTCCTCATGGATAAGTTG
GATTCAATAAGATATGTGACTAACTTAGCAAAAGAATTTTATATCCCAACTCTAGTACTTAGTTCTTCACTTGACTATTT
CTTAAGCATGGTTGAAGGTAACCTACCTGCAAACCTGATACAGGCGCAAAGAGATTTCTTTGGAGCCCACACCTATAGAA
GAATAGATAAAGAAGGAATTTTCCATACAGAATGGGAGCCAATTGATTAA

Upstream 100 bases:

>100_bases
ATTATTATGAAAAGAAATTTCAATTTTTCAAAAAATTATCTCGAGAGCTCAAAAGCCTATTCGAAGCTCACAGCAAATTA
TAAAACAGGAGGTATTAAAA

Downstream 100 bases:

>100_bases
ATGTTGAATTAGTGGGAGTTTCTTGTCCTCCCATTTTCTTTCAACAAAAATTCAATAAAAAAATTTAAAAATCAAGAAGG
ATTTTTTGGATTTGTGTAGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNEIGLIGLAVMGQNLALNIARKGYSVSVFNRTSEKTKEFLEERVKNEKIEGYHDIKSFVESLKKPRKIILMVKAGKPVD
DVIQELLPYLEKGDLIIDGGNSYFKDTSRRIKELKEKGILYLGMGVSGGEAGALHGPSLMPGGSIEAYEMVKDVLLKIAA
QTESGPCCTYVGNDSAGHFVKMVHNGIEYAIMQAISEVYDIMRKILKFSPEEIGDVFERWNNGELNSFLMEISFKIMRYK
DEETGKHLVDLILDEAEQKGTGKWTSQTALDLGIPTPSLSLAVEARSLSFFKEDRVKLSGKVKKTYPDVKLDKEKVIKDL
ENALLFSVFTSFSQGLWLIHEASKTFEYNIDLPEVLRIWKGGCIIRAKILDFLREILNENKENVNLLDSDKSISFLMDKL
DSIRYVTNLAKEFYIPTLVLSSSLDYFLSMVEGNLPANLIQAQRDFFGAHTYRRIDKEGIFHTEWEPID

Sequences:

>Translated_469_residues
MNEIGLIGLAVMGQNLALNIARKGYSVSVFNRTSEKTKEFLEERVKNEKIEGYHDIKSFVESLKKPRKIILMVKAGKPVD
DVIQELLPYLEKGDLIIDGGNSYFKDTSRRIKELKEKGILYLGMGVSGGEAGALHGPSLMPGGSIEAYEMVKDVLLKIAA
QTESGPCCTYVGNDSAGHFVKMVHNGIEYAIMQAISEVYDIMRKILKFSPEEIGDVFERWNNGELNSFLMEISFKIMRYK
DEETGKHLVDLILDEAEQKGTGKWTSQTALDLGIPTPSLSLAVEARSLSFFKEDRVKLSGKVKKTYPDVKLDKEKVIKDL
ENALLFSVFTSFSQGLWLIHEASKTFEYNIDLPEVLRIWKGGCIIRAKILDFLREILNENKENVNLLDSDKSISFLMDKL
DSIRYVTNLAKEFYIPTLVLSSSLDYFLSMVEGNLPANLIQAQRDFFGAHTYRRIDKEGIFHTEWEPID
>Mature_469_residues
MNEIGLIGLAVMGQNLALNIARKGYSVSVFNRTSEKTKEFLEERVKNEKIEGYHDIKSFVESLKKPRKIILMVKAGKPVD
DVIQELLPYLEKGDLIIDGGNSYFKDTSRRIKELKEKGILYLGMGVSGGEAGALHGPSLMPGGSIEAYEMVKDVLLKIAA
QTESGPCCTYVGNDSAGHFVKMVHNGIEYAIMQAISEVYDIMRKILKFSPEEIGDVFERWNNGELNSFLMEISFKIMRYK
DEETGKHLVDLILDEAEQKGTGKWTSQTALDLGIPTPSLSLAVEARSLSFFKEDRVKLSGKVKKTYPDVKLDKEKVIKDL
ENALLFSVFTSFSQGLWLIHEASKTFEYNIDLPEVLRIWKGGCIIRAKILDFLREILNENKENVNLLDSDKSISFLMDKL
DSIRYVTNLAKEFYIPTLVLSSSLDYFLSMVEGNLPANLIQAQRDFFGAHTYRRIDKEGIFHTEWEPID

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=466, Percent_Identity=46.137339055794, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1788341, Length=465, Percent_Identity=49.0322580645161, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17542558, Length=467, Percent_Identity=45.3961456102784, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321695, Length=471, Percent_Identity=46.7091295116773, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321977, Length=457, Percent_Identity=47.9212253829322, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=45.1612903225806, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53058; Mature: 53058

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIGLIGLAVMGQNLALNIARKGYSVSVFNRTSEKTKEFLEERVKNEKIEGYHDIKSFV
CCCCCEEEHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
ESLKKPRKIILMVKAGKPVDDVIQELLPYLEKGDLIIDGGNSYFKDTSRRIKELKEKGIL
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCEE
YLGMGVSGGEAGALHGPSLMPGGSIEAYEMVKDVLLKIAAQTESGPCCTYVGNDSAGHFV
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
KMVHNGIEYAIMQAISEVYDIMRKILKFSPEEIGDVFERWNNGELNSFLMEISFKIMRYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DEETGKHLVDLILDEAEQKGTGKWTSQTALDLGIPTPSLSLAVEARSLSFFKEDRVKLSG
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCC
KVKKTYPDVKLDKEKVIKDLENALLFSVFTSFSQGLWLIHEASKTFEYNIDLPEVLRIWK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHC
GGCIIRAKILDFLREILNENKENVNLLDSDKSISFLMDKLDSIRYVTNLAKEFYIPTLVL
CCCEEHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSLDYFLSMVEGNLPANLIQAQRDFFGAHTYRRIDKEGIFHTEWEPID
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MNEIGLIGLAVMGQNLALNIARKGYSVSVFNRTSEKTKEFLEERVKNEKIEGYHDIKSFV
CCCCCEEEHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
ESLKKPRKIILMVKAGKPVDDVIQELLPYLEKGDLIIDGGNSYFKDTSRRIKELKEKGIL
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCEE
YLGMGVSGGEAGALHGPSLMPGGSIEAYEMVKDVLLKIAAQTESGPCCTYVGNDSAGHFV
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
KMVHNGIEYAIMQAISEVYDIMRKILKFSPEEIGDVFERWNNGELNSFLMEISFKIMRYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DEETGKHLVDLILDEAEQKGTGKWTSQTALDLGIPTPSLSLAVEARSLSFFKEDRVKLSG
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCC
KVKKTYPDVKLDKEKVIKDLENALLFSVFTSFSQGLWLIHEASKTFEYNIDLPEVLRIWK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHC
GGCIIRAKILDFLREILNENKENVNLLDSDKSISFLMDKLDSIRYVTNLAKEFYIPTLVL
CCCEEHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSLDYFLSMVEGNLPANLIQAQRDFFGAHTYRRIDKEGIFHTEWEPID
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]