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The map label for this gene is UxaC

Identifier: 20808343

GI number: 20808343

Start: 1883318

End: 1884718

Strand: Reverse

Name: UxaC

Synonym: TTE1939

Alternate gene names: 20808343

Gene position: 1884718-1883318 (Counterclockwise)

Preceding gene: 20808344

Following gene: 20808342

Centisome position: 70.08

GC content: 33.83

Gene sequence:

>1401_bases
ATGAGAAAGTTTATGGATGAAGACTTTTTACTCACAAATGAAACAGCAGTGAAATTGTATCATCAATATGCAAAAGATAT
GTCAATTTATGACTTTCACTGCCATTTAAGTCCAAAAGAAATATATGAGGATAGGAGGTTTAAAAATATCACAGAGGTAT
GGCTATACGGCGACCATTACAAATGGAGGCTGATGAGAGCTAATGGTATAGATGAAAAATATATTACAGGGGATGCAGAT
GATTATGAAAAATTTGTTGCCTATGCTAAAACAATACCCATGGCAATAGGAAATCCCGTTTATCACTGGACTCATTTAGA
ATTGCAGAGATATTTTGGCATATATGACCTTTTAAATGAGAAGACAGCAAAGTCCATTTGGGAAAGAGCAAATGAAGTTA
TAAGTCAAGAAGATTTTAGTGCTAGAAATATATTGAAAAAATCAAATGTAAAAGTAGTGATAACTACAGATGACCCAGTG
GATTCATTAGAATATCACATCAAATTGAAAGAAGAAAAAGATTTTGACATAAAAGTTTTACCTGCTTTCAGACCAGATAA
GGGGCTAAATATAGAAAAAGATGATTTTCTCTCGTGGATTAAAAAATTAGAGAGTGCAAGTGGTATAAAAATAACCACAT
ATGATGACTTTCTACAGGCTCTTGAGAAAAGGATAGAATTTTTCCACTCTGTAGGATGTAGAATTTCTGACCATGCCCTA
GATTATGTATTTTATCAAAAGACATCAAAACAAGAAGCAGAAAAAGTATTTAAAAAGGTCCTGACGGAACAGCATTTAAC
AAAAGAAGAAATAGACAGTTTCAAAACATATACAATGATTTTCTTGGGTAAAAAATATGCTGAACTAAACTGGGTAATGC
AACTTCACATTGGAGCAATGAGAAACAATAATACTAAGATGTACAGAATTCTTGGACCGGATACAGGATATGATTCCATA
GGAGATTTTCCAATTGCTTATTCACTTTCAAGGCTTTTAGATTCTCTTGAAATAGAGGGTGCTCTGCCCAAAACAATTCT
ATATACACTGAATCCTGCTGCCAATTATGTGATTGCAACGATGATAGGGAATTTTCAAGACGGCAAGATAGCAGGAAAAA
TGCAATTTGGAGCTGCATGGTGGTTTAATGATAATAAAGATGGAATAAAGGAGCAGTTAAAGACTTTGGCAAATGTAGGA
TTGCTGGGGAGATTTGTAGGTATGGTGACAGACTCAAGAAGCTTCCTATCCTATGCAAGGCATGAATATTTTAGGAGAAT
ACTTTGCGATTTAATAGGTGAATGGGTAGAAAATGGAGAAGTGCCAAATGATATAGAATTATTAGGCAAAATAGTTCAGG
ATATTTCATTTAATAATGCGAAAGAGTACATGGGGGTATAA

Upstream 100 bases:

>100_bases
TGGGAGAAAGGATAGAAAGTTATTTCAAAGAGTTTATAGAAGGACCAGGTGCAGTGAGAAGAGTATTAGAAAAATATCTT
GGATGTAAGGAATGATGGCA

Downstream 100 bases:

>100_bases
ATATCTTAAAACGAAAGAAGTAAAGAAGATGGTAGAAAATGATATAAAGGAGGTGATATACCAAAGAAACATATTCAATA
CCTAGTTTAAAATGTTTAAG

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MRKFMDEDFLLTNETAVKLYHQYAKDMSIYDFHCHLSPKEIYEDRRFKNITEVWLYGDHYKWRLMRANGIDEKYITGDAD
DYEKFVAYAKTIPMAIGNPVYHWTHLELQRYFGIYDLLNEKTAKSIWERANEVISQEDFSARNILKKSNVKVVITTDDPV
DSLEYHIKLKEEKDFDIKVLPAFRPDKGLNIEKDDFLSWIKKLESASGIKITTYDDFLQALEKRIEFFHSVGCRISDHAL
DYVFYQKTSKQEAEKVFKKVLTEQHLTKEEIDSFKTYTMIFLGKKYAELNWVMQLHIGAMRNNNTKMYRILGPDTGYDSI
GDFPIAYSLSRLLDSLEIEGALPKTILYTLNPAANYVIATMIGNFQDGKIAGKMQFGAAWWFNDNKDGIKEQLKTLANVG
LLGRFVGMVTDSRSFLSYARHEYFRRILCDLIGEWVENGEVPNDIELLGKIVQDISFNNAKEYMGV

Sequences:

>Translated_466_residues
MRKFMDEDFLLTNETAVKLYHQYAKDMSIYDFHCHLSPKEIYEDRRFKNITEVWLYGDHYKWRLMRANGIDEKYITGDAD
DYEKFVAYAKTIPMAIGNPVYHWTHLELQRYFGIYDLLNEKTAKSIWERANEVISQEDFSARNILKKSNVKVVITTDDPV
DSLEYHIKLKEEKDFDIKVLPAFRPDKGLNIEKDDFLSWIKKLESASGIKITTYDDFLQALEKRIEFFHSVGCRISDHAL
DYVFYQKTSKQEAEKVFKKVLTEQHLTKEEIDSFKTYTMIFLGKKYAELNWVMQLHIGAMRNNNTKMYRILGPDTGYDSI
GDFPIAYSLSRLLDSLEIEGALPKTILYTLNPAANYVIATMIGNFQDGKIAGKMQFGAAWWFNDNKDGIKEQLKTLANVG
LLGRFVGMVTDSRSFLSYARHEYFRRILCDLIGEWVENGEVPNDIELLGKIVQDISFNNAKEYMGV
>Mature_466_residues
MRKFMDEDFLLTNETAVKLYHQYAKDMSIYDFHCHLSPKEIYEDRRFKNITEVWLYGDHYKWRLMRANGIDEKYITGDAD
DYEKFVAYAKTIPMAIGNPVYHWTHLELQRYFGIYDLLNEKTAKSIWERANEVISQEDFSARNILKKSNVKVVITTDDPV
DSLEYHIKLKEEKDFDIKVLPAFRPDKGLNIEKDDFLSWIKKLESASGIKITTYDDFLQALEKRIEFFHSVGCRISDHAL
DYVFYQKTSKQEAEKVFKKVLTEQHLTKEEIDSFKTYTMIFLGKKYAELNWVMQLHIGAMRNNNTKMYRILGPDTGYDSI
GDFPIAYSLSRLLDSLEIEGALPKTILYTLNPAANYVIATMIGNFQDGKIAGKMQFGAAWWFNDNKDGIKEQLKTLANVG
LLGRFVGMVTDSRSFLSYARHEYFRRILCDLIGEWVENGEVPNDIELLGKIVQDISFNNAKEYMGV

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=467, Percent_Identity=54.8179871520343, Blast_Score=560, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_THETN (Q8R8Q6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623514.1
- ProteinModelPortal:   Q8R8Q6
- SMR:   Q8R8Q6
- GeneID:   997134
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1939
- NMPDR:   fig|273068.3.peg.1801
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   TTEN273068:TTE1939-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54326; Mature: 54326

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFMDEDFLLTNETAVKLYHQYAKDMSIYDFHCHLSPKEIYEDRRFKNITEVWLYGDHY
CCCCCCCCCEEECHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCEEEEEECCCE
KWRLMRANGIDEKYITGDADDYEKFVAYAKTIPMAIGNPVYHWTHLELQRYFGIYDLLNE
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
KTAKSIWERANEVISQEDFSARNILKKSNVKVVITTDDPVDSLEYHIKLKEEKDFDIKVL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCEEEE
PAFRPDKGLNIEKDDFLSWIKKLESASGIKITTYDDFLQALEKRIEFFHSVGCRISDHAL
ECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECHHHH
DYVFYQKTSKQEAEKVFKKVLTEQHLTKEEIDSFKTYTMIFLGKKYAELNWVMQLHIGAM
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCHHHHHHHHEEEEEHHE
RNNNTKMYRILGPDTGYDSIGDFPIAYSLSRLLDSLEIEGALPKTILYTLNPAANYVIAT
ECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHEEEEH
MIGNFQDGKIAGKMQFGAAWWFNDNKDGIKEQLKTLANVGLLGRFVGMVTDSRSFLSYAR
HHCCCCCCCEEEEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRILCDLIGEWVENGEVPNDIELLGKIVQDISFNNAKEYMGV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure
MRKFMDEDFLLTNETAVKLYHQYAKDMSIYDFHCHLSPKEIYEDRRFKNITEVWLYGDHY
CCCCCCCCCEEECHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCEEEEEECCCE
KWRLMRANGIDEKYITGDADDYEKFVAYAKTIPMAIGNPVYHWTHLELQRYFGIYDLLNE
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
KTAKSIWERANEVISQEDFSARNILKKSNVKVVITTDDPVDSLEYHIKLKEEKDFDIKVL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCEEEE
PAFRPDKGLNIEKDDFLSWIKKLESASGIKITTYDDFLQALEKRIEFFHSVGCRISDHAL
ECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECHHHH
DYVFYQKTSKQEAEKVFKKVLTEQHLTKEEIDSFKTYTMIFLGKKYAELNWVMQLHIGAM
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCHHHHHHHHEEEEEHHE
RNNNTKMYRILGPDTGYDSIGDFPIAYSLSRLLDSLEIEGALPKTILYTLNPAANYVIAT
ECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHEEEEH
MIGNFQDGKIAGKMQFGAAWWFNDNKDGIKEQLKTLANVGLLGRFVGMVTDSRSFLSYAR
HHCCCCCCCEEEEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HEYFRRILCDLIGEWVENGEVPNDIELLGKIVQDISFNNAKEYMGV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336