Click here to switch to the map view.

The map label for this gene is SelA

Identifier: 20808284

GI number: 20808284

Start: 1816203

End: 1817588

Strand: Reverse

Name: SelA

Synonym: TTE1872

Alternate gene names: 20808284

Gene position: 1817588-1816203 (Counterclockwise)

Preceding gene: 20808285

Following gene: 20808283

Centisome position: 67.58

GC content: 38.67

Gene sequence:

>1386_bases
ATGGAGGACTTGTACAGAAAACTTCCGTCAGTAGATGAGATACTTAGGGAAGAAAAAATAAATGAGGTTTTGAAATTTAA
TAAGAGGGAAGTAGTAAAAAACTGTATAAGGGAAGTTCTTGAAAGATACAGAGAAAAAATTAGAAGGGGAGAAGTAAAAA
AGATTGACATAGAAAAAATTTTGGAAGATGTGGTAAGCCAGATTGAAGAGAAAAAGAAAATGAGCTTGAGGAGGGTAGTG
AATGGAACAGGAATTATTCTACACACAAATCTTGGAAGAGCTCTATTCCCTCCTCAAGTGAAAGAACATCTGTTAGATAT
AGCCTTTTGCTATTCCACTTTAGAGTATGATGTGGAAAAAGGAGAGAGGGGTTCTAGGTATTCTCATGTAGAAAAGCTTT
TGTGCGAACTTTTGGATGTGGAGGCAGCTTTGGTTGTAAATAATAATGCAGCTGCTGTGCTCCTTGCTCTTAACACTCTC
GCTAAAGGGAAAGAGGTTATAGTTTCAAGGGGACAGCTTATTGAAATAGGAGGATCTTTTAGAATTCCCGATGTAATGCT
TCAAAGCGGAGCCATTTTAAAAGAAGTGGGTACTACGAACAAGACTTACGACTTTGACTATATAAATGCTATTACTGAGA
ATACCGCTCTTCTCTTAAAAGTTCACACCAGCAACTACAGAATTGTAGGTTTCACCCATGACATAGCAACTGAGGAATTG
GTTCAGATTGGCAGGAAGTACGACATTCCTACAATGGAGGATTTGGGCAGCGGAGTTATGGTAGATTTAAGAGAATACGG
TTTGCCCCATGAACCAACTGTCCAGGAAGTTGTAAAAGCAGGTGTGGATATTGTCACTTTCAGTGGAGATAAGCTTTTGG
GCGGACCACAGGCCGGGATAATCGTCGGGAAGAAAAAATACATTGACCTCATGAAAAAGAATCCTCTTACAAGGGCATTG
AGAGTGGATAAGCTTTGTCTTGTCTCTCTAGAATGTGTGTTAAGAATTTATAGGGATTCTAATCCAGTAGAAGCCATCCC
TACTTTAAAGATGCTGACTGCAAAACCTTCCCAATTATATGAAAAGGCAGCTATCTTAAATAAGCTTGTTTTAACAATTC
CTAAAGTTAAATCAAAAGTTGTAGAAATTACATCCTTGTCGGGGGGAGGATCACTGCCAGAAGAAAGTTTGCCTTCCTAT
GGTATTACTTTAGAGGTGGAAGGGTTTGATACTGAAGATTTAGAAAGAAGGCTAAGAATACGAGATATTCCTATAATAAC
CCGTATAGTTGATGGTGTTGTTACAATAGATGTGAGGACTTTATTAGAGGGTGATGAAGAGGTAATTCTTCATGCTCTAG
AAGAAATAACGGGGGTGTGCCAGTGA

Upstream 100 bases:

>100_bases
AATAAAAAGTTAAAATTTGGAGCTTTTATTGTAGGAAGGGTGAAAGAAAAACAAGAATATGATATTTATGTCAGATAACT
CCGGCGAGAGGAGCTGTGCT

Downstream 100 bases:

>100_bases
AAAATATTATAATTGGCACAGCAGGACATATTGACCACGGTAAAACGACCTTGATAAAAGCTCTTACAGGGAAGGATACA
GATAGGCTCAAAGAAGAAAA

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MEDLYRKLPSVDEILREEKINEVLKFNKREVVKNCIREVLERYREKIRRGEVKKIDIEKILEDVVSQIEEKKKMSLRRVV
NGTGIILHTNLGRALFPPQVKEHLLDIAFCYSTLEYDVEKGERGSRYSHVEKLLCELLDVEAALVVNNNAAAVLLALNTL
AKGKEVIVSRGQLIEIGGSFRIPDVMLQSGAILKEVGTTNKTYDFDYINAITENTALLLKVHTSNYRIVGFTHDIATEEL
VQIGRKYDIPTMEDLGSGVMVDLREYGLPHEPTVQEVVKAGVDIVTFSGDKLLGGPQAGIIVGKKKYIDLMKKNPLTRAL
RVDKLCLVSLECVLRIYRDSNPVEAIPTLKMLTAKPSQLYEKAAILNKLVLTIPKVKSKVVEITSLSGGGSLPEESLPSY
GITLEVEGFDTEDLERRLRIRDIPIITRIVDGVVTIDVRTLLEGDEEVILHALEEITGVCQ

Sequences:

>Translated_461_residues
MEDLYRKLPSVDEILREEKINEVLKFNKREVVKNCIREVLERYREKIRRGEVKKIDIEKILEDVVSQIEEKKKMSLRRVV
NGTGIILHTNLGRALFPPQVKEHLLDIAFCYSTLEYDVEKGERGSRYSHVEKLLCELLDVEAALVVNNNAAAVLLALNTL
AKGKEVIVSRGQLIEIGGSFRIPDVMLQSGAILKEVGTTNKTYDFDYINAITENTALLLKVHTSNYRIVGFTHDIATEEL
VQIGRKYDIPTMEDLGSGVMVDLREYGLPHEPTVQEVVKAGVDIVTFSGDKLLGGPQAGIIVGKKKYIDLMKKNPLTRAL
RVDKLCLVSLECVLRIYRDSNPVEAIPTLKMLTAKPSQLYEKAAILNKLVLTIPKVKSKVVEITSLSGGGSLPEESLPSY
GITLEVEGFDTEDLERRLRIRDIPIITRIVDGVVTIDVRTLLEGDEEVILHALEEITGVCQ
>Mature_461_residues
MEDLYRKLPSVDEILREEKINEVLKFNKREVVKNCIREVLERYREKIRRGEVKKIDIEKILEDVVSQIEEKKKMSLRRVV
NGTGIILHTNLGRALFPPQVKEHLLDIAFCYSTLEYDVEKGERGSRYSHVEKLLCELLDVEAALVVNNNAAAVLLALNTL
AKGKEVIVSRGQLIEIGGSFRIPDVMLQSGAILKEVGTTNKTYDFDYINAITENTALLLKVHTSNYRIVGFTHDIATEEL
VQIGRKYDIPTMEDLGSGVMVDLREYGLPHEPTVQEVVKAGVDIVTFSGDKLLGGPQAGIIVGKKKYIDLMKKNPLTRAL
RVDKLCLVSLECVLRIYRDSNPVEAIPTLKMLTAKPSQLYEKAAILNKLVLTIPKVKSKVVEITSLSGGGSLPEESLPSY
GITLEVEGFDTEDLERRLRIRDIPIITRIVDGVVTIDVRTLLEGDEEVILHALEEITGVCQ

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=456, Percent_Identity=45.1754385964912, Blast_Score=347, Evalue=9e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_THETN (Q8R8W4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623455.1
- ProteinModelPortal:   Q8R8W4
- GeneID:   997066
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1872
- NMPDR:   fig|273068.3.peg.1742
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- ProtClustDB:   PRK04311
- BioCyc:   TTEN273068:TTE1872-MONOMER
- BRENDA:   2.9.1.1
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 51669; Mature: 51669

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLYRKLPSVDEILREEKINEVLKFNKREVVKNCIREVLERYREKIRRGEVKKIDIEKI
CCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
LEDVVSQIEEKKKMSLRRVVNGTGIILHTNLGRALFPPQVKEHLLDIAFCYSTLEYDVEK
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GERGSRYSHVEKLLCELLDVEAALVVNNNAAAVLLALNTLAKGKEVIVSRGQLIEIGGSF
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHHCCCHHHHCCCCEEEECCCC
RIPDVMLQSGAILKEVGTTNKTYDFDYINAITENTALLLKVHTSNYRIVGFTHDIATEEL
CCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCEEEEEEEHHHHHHHH
VQIGRKYDIPTMEDLGSGVMVDLREYGLPHEPTVQEVVKAGVDIVTFSGDKLLGGPQAGI
HHHCCCCCCCCHHHCCCCEEEEHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCE
IVGKKKYIDLMKKNPLTRALRVDKLCLVSLECVLRIYRDSNPVEAIPTLKMLTAKPSQLY
EECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHH
EKAAILNKLVLTIPKVKSKVVEITSLSGGGSLPEESLPSYGITLEVEGFDTEDLERRLRI
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHH
RDIPIITRIVDGVVTIDVRTLLEGDEEVILHALEEITGVCQ
CCCHHHHHHHCCHHEEEHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDLYRKLPSVDEILREEKINEVLKFNKREVVKNCIREVLERYREKIRRGEVKKIDIEKI
CCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
LEDVVSQIEEKKKMSLRRVVNGTGIILHTNLGRALFPPQVKEHLLDIAFCYSTLEYDVEK
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GERGSRYSHVEKLLCELLDVEAALVVNNNAAAVLLALNTLAKGKEVIVSRGQLIEIGGSF
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHHCCCHHHHCCCCEEEECCCC
RIPDVMLQSGAILKEVGTTNKTYDFDYINAITENTALLLKVHTSNYRIVGFTHDIATEEL
CCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCEEEEEEEHHHHHHHH
VQIGRKYDIPTMEDLGSGVMVDLREYGLPHEPTVQEVVKAGVDIVTFSGDKLLGGPQAGI
HHHCCCCCCCCHHHCCCCEEEEHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCE
IVGKKKYIDLMKKNPLTRALRVDKLCLVSLECVLRIYRDSNPVEAIPTLKMLTAKPSQLY
EECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHH
EKAAILNKLVLTIPKVKSKVVEITSLSGGGSLPEESLPSYGITLEVEGFDTEDLERRLRI
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHH
RDIPIITRIVDGVVTIDVRTLLEGDEEVILHALEEITGVCQ
CCCHHHHHHHCCHHEEEHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336