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The map label for this gene is NorM2 [H]

Identifier: 20808228

GI number: 20808228

Start: 1757367

End: 1758716

Strand: Direct

Name: NorM2 [H]

Synonym: TTE1811

Alternate gene names: 20808228

Gene position: 1757367-1758716 (Clockwise)

Preceding gene: 20808225

Following gene: 20808294

Centisome position: 65.34

GC content: 39.85

Gene sequence:

>1350_bases
ATGAGTAGCAAAAAAGAAGTAAAAAAAATACTCAACTTGGCTTTACCTGCTGTAGGGGAAATGCTTCTTTACATGGTAGT
ATGGGTACTAGACACCATGATGGTGGGGCAGTATGGCGGAAAAGACAGCGTTAGCGCTGTAGGACTAGCGTCAGAAATAA
TATACACTTTCGCTGCAATATTTGTAACAATGGGAATAGCCATAGGAGTTACCTCTTATGTTGCTCGAAGCATTGGAGCT
CAGGAATTTGAAAAGGCAAAAAGGTATGCCAGTCAGGGAATCTTTTTAGGGATACTAGGCAGTTTTATAATTTCTTCTCT
AATGTTCCTACTGGCAGAAAAAATACTAATCTTAGCTGGTGCAAGTGGAAACGTCCTTGCGCTGGGAAAAGTTTTTATGA
AAATAGCTTCTGTAGGGATATTCTTCAACATGGTGATGAGCACTTTAAATGCCATTTTAAGAGCTACAGGAAACACTAAG
ACTCCCATGACAGCTGCTGCTATTGTAGTGATACTCAATATTCTACTGGATTGGATTCTAATCTTTGGAAAGCTGGGCTT
CCCTGCTCTAGGGGTTAAAGGGTCTGCTATTGCTACGACAATCGCCCATATAGTAGGATTTTTCTTTGTTTTATGGTATT
ATATAATCCAGAAAACCTTGAATCTAACTTTTAGAGATGTTTTACAATATCATCATAAGTTAGCCATAGAAATAATAAAA
CTTTCTATCCCCGCCTCACTTCAGGAAGCAGCTTTTGATATAAGTAGGCTCTTATCTATTTTCATGATAATGCATCTGGG
CACAGTGGCTTTTGCTGCAAATCAAATAGCTACAACTATAGAGTCTATTTCCTTCATGCCAGGATGGGGATTTGCTGTCG
CTGCAACCACTATGGCAGGACAAATGGTGGGGGCAAAAAATTATGAAGGGGCTATTAGGTACACGAGAATTTCTGCCACA
TTTGCCGCCTCTATCATGGGAACAATGTCTTTACTCTTTCTCACAATACCCAAACTTTTAATGAGAGCCTTCATAAACGA
TCCAGAAGTAATAGCAGTGGGAGCTTTATGCCTTATGGTAGCTTCAATAGAACAGCCCTTTATGGCTCTAGGAATGGTGT
ACGGGGGTGGTTTAAAAGGAAGTGGAAATACAAAAATTCCTTTTATCATATCCACAATCTCAAGCTGGCTGATTCGATTG
CCTTTAATGTACGTGGTCATATACATCCTTAAATGGGGAGTCGTAGCAGTTTGGTTTGTAACTGCTCTCCAGTGGTCTTT
CGAAGGAACTGCCATGTACCTCTTCTTCAAGAGAGAGATAAACAAACTAAAAAGAGCAGTAAAAGGGTAA

Upstream 100 bases:

>100_bases
TCAATAAAAGTACATGTGTTATAATACTGTTAGTGTAATTTTTGAACTATACATAAAACAGCGTTAAAGCTTGCTTTGTA
CTAGTTTTAGGGGGTGTTAT

Downstream 100 bases:

>100_bases
CTCCCCTTTACCGCTCTTTTAAACTTTTTTCGACTTCTTTTAAAGTTTGATATATTTTCTACATTCTTTCTACTAAGGCC
ACGCTTTCCACATGATAAGT

Product: Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSSKKEVKKILNLALPAVGEMLLYMVVWVLDTMMVGQYGGKDSVSAVGLASEIIYTFAAIFVTMGIAIGVTSYVARSIGA
QEFEKAKRYASQGIFLGILGSFIISSLMFLLAEKILILAGASGNVLALGKVFMKIASVGIFFNMVMSTLNAILRATGNTK
TPMTAAAIVVILNILLDWILIFGKLGFPALGVKGSAIATTIAHIVGFFFVLWYYIIQKTLNLTFRDVLQYHHKLAIEIIK
LSIPASLQEAAFDISRLLSIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKNYEGAIRYTRISAT
FAASIMGTMSLLFLTIPKLLMRAFINDPEVIAVGALCLMVASIEQPFMALGMVYGGGLKGSGNTKIPFIISTISSWLIRL
PLMYVVIYILKWGVVAVWFVTALQWSFEGTAMYLFFKREINKLKRAVKG

Sequences:

>Translated_449_residues
MSSKKEVKKILNLALPAVGEMLLYMVVWVLDTMMVGQYGGKDSVSAVGLASEIIYTFAAIFVTMGIAIGVTSYVARSIGA
QEFEKAKRYASQGIFLGILGSFIISSLMFLLAEKILILAGASGNVLALGKVFMKIASVGIFFNMVMSTLNAILRATGNTK
TPMTAAAIVVILNILLDWILIFGKLGFPALGVKGSAIATTIAHIVGFFFVLWYYIIQKTLNLTFRDVLQYHHKLAIEIIK
LSIPASLQEAAFDISRLLSIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKNYEGAIRYTRISAT
FAASIMGTMSLLFLTIPKLLMRAFINDPEVIAVGALCLMVASIEQPFMALGMVYGGGLKGSGNTKIPFIISTISSWLIRL
PLMYVVIYILKWGVVAVWFVTALQWSFEGTAMYLFFKREINKLKRAVKG
>Mature_448_residues
SSKKEVKKILNLALPAVGEMLLYMVVWVLDTMMVGQYGGKDSVSAVGLASEIIYTFAAIFVTMGIAIGVTSYVARSIGAQ
EFEKAKRYASQGIFLGILGSFIISSLMFLLAEKILILAGASGNVLALGKVFMKIASVGIFFNMVMSTLNAILRATGNTKT
PMTAAAIVVILNILLDWILIFGKLGFPALGVKGSAIATTIAHIVGFFFVLWYYIIQKTLNLTFRDVLQYHHKLAIEIIKL
SIPASLQEAAFDISRLLSIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKNYEGAIRYTRISATF
AASIMGTMSLLFLTIPKLLMRAFINDPEVIAVGALCLMVASIEQPFMALGMVYGGGLKGSGNTKIPFIISTISSWLIRLP
LMYVVIYILKWGVVAVWFVTALQWSFEGTAMYLFFKREINKLKRAVKG

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=469, Percent_Identity=22.8144989339019, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI226510954, Length=435, Percent_Identity=26.6666666666667, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI48994890, Length=411, Percent_Identity=22.1411192214112, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48836; Mature: 48705

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKKEVKKILNLALPAVGEMLLYMVVWVLDTMMVGQYGGKDSVSAVGLASEIIYTFAAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH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HHHHHCCCCCEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]