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The map label for this gene is PepD

Identifier: 20808225

GI number: 20808225

Start: 1754223

End: 1755452

Strand: Direct

Name: PepD

Synonym: TTE1808

Alternate gene names: 20808225

Gene position: 1754223-1755452 (Clockwise)

Preceding gene: 20808224

Following gene: 20808228

Centisome position: 65.23

GC content: 37.89

Gene sequence:

>1230_bases
TTGTCAAAAGTAGTTGAACGTTTTTTGAAATATGTAAAATACCACACAACTTCAGATGAAAATTCCAACACTTTCCCGAG
TACAGAAGGACAGCTTATCTTTGCAAGAGAACTAGCAAAAGAATTAAAAGAATTAGGACTATCTGAGGTAGAGGTAGACG
AAAATGGATACGTCACAGCACTGCTTTCTGCCAACACAGATAAAAAAATCCCTACCATAGGTTTTATAGCTCATATGGAT
ACAAGCCCTGACATGTGCGGTAAAGACGTAAAACCACAAATAATTGAAAATTATGACGGAAATGATATAGTGCTAAACAA
AGAAAAAGGCATAATCCTCTCTACAAGTGAATTCCCTGAATTAAAAAACTACATAGGAAAGACCTTGATAACAACAGACG
GCACTACCCTTTTGGGGGCTGACGACAAAGCTGGAATAGCAGAGATAATCACTGCAATTGAGTATTTAATAAACCACCCA
GAAATAGAACATGGCAATGTAAAAATTGCCTTTACTCCTGACGAAGAAATTGGAAGAGGAGTAGACAAATTCAACGTAAA
AAAATTCGCCTGCGATTTTGCCTACACTGTAGACGGAGGAGAACTTGGCACCATAGAGTACGAAAATTTCAATGCTGCTA
GCGCTAAAATAAAGATACACGGCAGAAATGTTCATCCTGGAACTGCAAAAGGCAAAATGAAAAATTCCATTTTAATAGGA
ATAGAGCTTCAGAACATGCTGCCAGAACTAGAAAGACCTGAACACACAGAAGGATATCAGGGCTTCTACCACTTAAATAA
CTTTCAAGGCACTGTAGAAGAAACATCAATGTATTACATCATAAGAGATTTTGACAAACAGGCTTTTTCAGATAAAAAGG
AGTATATAAAAAGCATAGTAGAAGCTCTAAATAAAAAATATGGAGAAGGTACAGTAGAGCTGGAACTTAAAGACCAGTAC
TATAACATGAGAGAAGTTATAGAAAAGCACATGCACATAGTAGAAACTGCCATGGAAGCAATGAGGTCTTTGGGCATTGA
ACCAAAGGTGGTGCCAATAAGAGGAGGAACTGACGGAGCACGACTGAGTTTTATGGGACTTCCTACCCCTAATTTGTTCA
CTGGAGGGCATAATTTCCACGGCAAATATGAATTCATACCGATCCACGCCATGGAAAAAGCAGTTGAAGTGATAGTAAAA
ATTGTGGAACTTTATGGGAAAAAGGGATAG

Upstream 100 bases:

>100_bases
ATCGCTCGGTTACCCTGCTGAAGATCCACAACCCAAATACAAAAAAGACCTTTCTGAAGTTTTACACTGGGAAAAATTTT
AAGAGAAAGAGGGGTTAAAA

Downstream 100 bases:

>100_bases
CAAAAGGCTATCCCTTTAATTCTCTTTCAAAGAACTTCACAGATTCTTCTATCGCTTTTCTTTCCCATTCAAGGTTTTTA
AAAGTATGGTCCGCTCCTTC

Product: peptidase T

Products: NA

Alternate protein names: Aminotripeptidase; Tripeptidase; Tripeptide aminopeptidase

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSKVVERFLKYVKYHTTSDENSNTFPSTEGQLIFARELAKELKELGLSEVEVDENGYVTALLSANTDKKIPTIGFIAHMD
TSPDMCGKDVKPQIIENYDGNDIVLNKEKGIILSTSEFPELKNYIGKTLITTDGTTLLGADDKAGIAEIITAIEYLINHP
EIEHGNVKIAFTPDEEIGRGVDKFNVKKFACDFAYTVDGGELGTIEYENFNAASAKIKIHGRNVHPGTAKGKMKNSILIG
IELQNMLPELERPEHTEGYQGFYHLNNFQGTVEETSMYYIIRDFDKQAFSDKKEYIKSIVEALNKKYGEGTVELELKDQY
YNMREVIEKHMHIVETAMEAMRSLGIEPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGKYEFIPIHAMEKAVEVIVK
IVELYGKKG

Sequences:

>Translated_409_residues
MSKVVERFLKYVKYHTTSDENSNTFPSTEGQLIFARELAKELKELGLSEVEVDENGYVTALLSANTDKKIPTIGFIAHMD
TSPDMCGKDVKPQIIENYDGNDIVLNKEKGIILSTSEFPELKNYIGKTLITTDGTTLLGADDKAGIAEIITAIEYLINHP
EIEHGNVKIAFTPDEEIGRGVDKFNVKKFACDFAYTVDGGELGTIEYENFNAASAKIKIHGRNVHPGTAKGKMKNSILIG
IELQNMLPELERPEHTEGYQGFYHLNNFQGTVEETSMYYIIRDFDKQAFSDKKEYIKSIVEALNKKYGEGTVELELKDQY
YNMREVIEKHMHIVETAMEAMRSLGIEPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGKYEFIPIHAMEKAVEVIVK
IVELYGKKG
>Mature_408_residues
SKVVERFLKYVKYHTTSDENSNTFPSTEGQLIFARELAKELKELGLSEVEVDENGYVTALLSANTDKKIPTIGFIAHMDT
SPDMCGKDVKPQIIENYDGNDIVLNKEKGIILSTSEFPELKNYIGKTLITTDGTTLLGADDKAGIAEIITAIEYLINHPE
IEHGNVKIAFTPDEEIGRGVDKFNVKKFACDFAYTVDGGELGTIEYENFNAASAKIKIHGRNVHPGTAKGKMKNSILIGI
ELQNMLPELERPEHTEGYQGFYHLNNFQGTVEETSMYYIIRDFDKQAFSDKKEYIKSIVEALNKKYGEGTVELELKDQYY
NMREVIEKHMHIVETAMEAMRSLGIEPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGKYEFIPIHAMEKAVEVIVKI
VELYGKKG

Specific function: Cleaves the N-terminal amino acid of tripeptides

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20B family

Homologues:

Organism=Escherichia coli, GI1787372, Length=412, Percent_Identity=53.1553398058252, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPT_THETN (Q8R922)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623396.1
- ProteinModelPortal:   Q8R922
- SMR:   Q8R922
- MEROPS:   M20.003
- GeneID:   996989
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1808
- NMPDR:   fig|273068.3.peg.1338
- HOGENOM:   HBG288638
- OMA:   HMDTAPD
- ProtClustDB:   PRK05469
- BioCyc:   TTEN273068:TTE1808-MONOMER
- BRENDA:   3.4.11.4
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00550
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR010161
- PIRSF:   PIRSF037215
- TIGRFAMs:   TIGR01882

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.4.11.4

Molecular weight: Translated: 45850; Mature: 45719

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 80-80 ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVVERFLKYVKYHTTSDENSNTFPSTEGQLIFARELAKELKELGLSEVEVDENGYVTA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCEEE
LLSANTDKKIPTIGFIAHMDTSPDMCGKDVKPQIIENYDGNDIVLNKEKGIILSTSEFPE
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEECCCCHH
LKNYIGKTLITTDGTTLLGADDKAGIAEIITAIEYLINHPEIEHGNVKIAFTPDEEIGRG
HHHHCCCEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCC
VDKFNVKKFACDFAYTVDGGELGTIEYENFNAASAKIKIHGRNVHPGTAKGKMKNSILIG
CCCCCCEEEEEEEEEEECCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEE
IELQNMLPELERPEHTEGYQGFYHLNNFQGTVEETSMYYIIRDFDKQAFSDKKEYIKSIV
EEHHHHCCCCCCCCCCCCCCCEEEECCCCCCEECCEEEEEEEECCHHHHHHHHHHHHHHH
EALNKKYGEGTVELELKDQYYNMREVIEKHMHIVETAMEAMRSLGIEPKVVPIRGGTDGA
HHHHHHCCCCEEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
RLSFMGLPTPNLFTGGHNFHGKYEFIPIHAMEKAVEVIVKIVELYGKKG
EEEEEECCCCCEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKVVERFLKYVKYHTTSDENSNTFPSTEGQLIFARELAKELKELGLSEVEVDENGYVTA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCEEE
LLSANTDKKIPTIGFIAHMDTSPDMCGKDVKPQIIENYDGNDIVLNKEKGIILSTSEFPE
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEECCCCHH
LKNYIGKTLITTDGTTLLGADDKAGIAEIITAIEYLINHPEIEHGNVKIAFTPDEEIGRG
HHHHCCCEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCC
VDKFNVKKFACDFAYTVDGGELGTIEYENFNAASAKIKIHGRNVHPGTAKGKMKNSILIG
CCCCCCEEEEEEEEEEECCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEE
IELQNMLPELERPEHTEGYQGFYHLNNFQGTVEETSMYYIIRDFDKQAFSDKKEYIKSIV
EEHHHHCCCCCCCCCCCCCCCEEEECCCCCCEECCEEEEEEEECCHHHHHHHHHHHHHHH
EALNKKYGEGTVELELKDQYYNMREVIEKHMHIVETAMEAMRSLGIEPKVVPIRGGTDGA
HHHHHHCCCCEEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
RLSFMGLPTPNLFTGGHNFHGKYEFIPIHAMEKAVEVIVKIVELYGKKG
EEEEEECCCCCEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336