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The map label for this gene is NuoL2 [H]

Identifier: 20808127

GI number: 20808127

Start: 1649435

End: 1650874

Strand: Reverse

Name: NuoL2 [H]

Synonym: TTE1701

Alternate gene names: 20808127

Gene position: 1650874-1649435 (Counterclockwise)

Preceding gene: 20808128

Following gene: 20808126

Centisome position: 61.38

GC content: 42.29

Gene sequence:

>1440_bases
ATGGTTTGGTATGCACTGGGCAGCATCCTTCTACCATTGGTAGGAAGTTTAGTTGTGCTGTTTTTGTCAGAACAACAGGT
AAAAAAGGCAGGTCAGTTGTTCTCTTTCCTGGCCTTTCTGTGTGGTTTGGCCTTATTGGTTTCTTTTGCACTAACCGGTG
AAAGTTTTAGCCGGGAATTGGTGGCTATAAATGGTGTAACCTGCTATGGGATTACTGTAGATGCTTTAAGCGTTTTGACC
AACTTTTTAGTAGTTTTAATTGGATGGCTTATATGTACCTATTCAGCGGGATATATGAGCCCCGATAACAGAGAGCATCC
AATTTGCGAGGGGATTAACAGGTTTTATTCTCTCATGCTGCTTTTTATCGGTTCTATGGCGGGTGTGGTTTTCTCTACAA
CATTACTTGGACTTTTGTTTTTCTTTGAAATTACCGGTATTTGTTCATGGAGCTTGATTGGATTTTATGGAGATGAAAAA
TCCCGAAAGTCCGCCCTTTGGGCAATTGCACTTACTCATTCTGCTGCACTGGGACTTTATGTGGCTACTGCTTATCTTTA
CGTAAAGACGGGCAGCTTTTCTGTAACCGCTCTTGGCAAATTGACGGAGGCGGAAAAAACCATTGCTTTTATAGGAATCC
TGATCGCCTGCTGGGGAAAGTCTGCACAACTTCCTTTTCATCCCTGGCTTCCGCGGGCGATGGTGGCACCTACTCCCGTC
AGTGCCTATTTGCATGCTGCTTCAATGGTCAAAGTCGGAGTCTATATCTACGCCAGAACTGTCCTGGCGGCGGGGAAAGT
TCCAGCAGTAATCGGCCAGGTTGGGGCTATTATGGCAGTGATTACCATGATATATGGATTTATCATGTATTTTCCACAGC
AGGATATGAAGCGACTGCTTGCTTATTCTACTATCACCCAGCTTTCCTATATTTTTCTGGCTATTTCTATCTTCATTTTG
GGTTCACAAATGGCTTTTAAAGGAGGGGTAGCCCATATCTTTAACCATGCCTTTGGCAAAAGCCTGTTTTTCTTGGTGGC
AGGGGCACTGTCTTATACAACTGGTACCCGTAAGCTTCTAATGTTCAGAGGAATTTTAAAAAAAATGCCCGTCATTGGCC
TGGGATATATTGCGGCTTCGATGGCCATAACTGGTGTTCCTCCTTTTAATGGTTTTTTCAGTAAAATTATGATCATAATT
AGCGGTTTTGAGATTAGCAGGCACAATTTATTGATTCTTATTTTAACTATTATAACTGTCATTGAGTCTGTTGGAAGTTT
TATATGGTTTCTCAAATGGATGGGAACAAATGTCTTTGGTACACCTTCCGAAACGGTGGCTACTGCTGGAAAACCTCCGC
TGGCTATCAAGTTTGTCCTTGCCTTTCTCATAATTATGACTCTTATATCCCAATACATTGCTTTGGCGCTGTTAAGTTAA

Upstream 100 bases:

>100_bases
CTTGTTTGTGTTTATGGCAGCGCTGGGGTTACATTTGCCTTCTACTTTAAGTCAACTATTGCAAAGGGCAGTGACCATTG
TTTTAGGAGGGACGATATAA

Downstream 100 bases:

>100_bases
AAATTGGGTATGTGTCAGAATAAAAAGGAGGTTGAAAAGGGTGGAGAATGAAATAAAGGCACAACAAGACAGAAAAAAAT
ATGTTAGGGCTTTGTACTCA

Product: hydrogenase 4 subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MVWYALGSILLPLVGSLVVLFLSEQQVKKAGQLFSFLAFLCGLALLVSFALTGESFSRELVAINGVTCYGITVDALSVLT
NFLVVLIGWLICTYSAGYMSPDNREHPICEGINRFYSLMLLFIGSMAGVVFSTTLLGLLFFFEITGICSWSLIGFYGDEK
SRKSALWAIALTHSAALGLYVATAYLYVKTGSFSVTALGKLTEAEKTIAFIGILIACWGKSAQLPFHPWLPRAMVAPTPV
SAYLHAASMVKVGVYIYARTVLAAGKVPAVIGQVGAIMAVITMIYGFIMYFPQQDMKRLLAYSTITQLSYIFLAISIFIL
GSQMAFKGGVAHIFNHAFGKSLFFLVAGALSYTTGTRKLLMFRGILKKMPVIGLGYIAASMAITGVPPFNGFFSKIMIII
SGFEISRHNLLILILTIITVIESVGSFIWFLKWMGTNVFGTPSETVATAGKPPLAIKFVLAFLIIMTLISQYIALALLS

Sequences:

>Translated_479_residues
MVWYALGSILLPLVGSLVVLFLSEQQVKKAGQLFSFLAFLCGLALLVSFALTGESFSRELVAINGVTCYGITVDALSVLT
NFLVVLIGWLICTYSAGYMSPDNREHPICEGINRFYSLMLLFIGSMAGVVFSTTLLGLLFFFEITGICSWSLIGFYGDEK
SRKSALWAIALTHSAALGLYVATAYLYVKTGSFSVTALGKLTEAEKTIAFIGILIACWGKSAQLPFHPWLPRAMVAPTPV
SAYLHAASMVKVGVYIYARTVLAAGKVPAVIGQVGAIMAVITMIYGFIMYFPQQDMKRLLAYSTITQLSYIFLAISIFIL
GSQMAFKGGVAHIFNHAFGKSLFFLVAGALSYTTGTRKLLMFRGILKKMPVIGLGYIAASMAITGVPPFNGFFSKIMIII
SGFEISRHNLLILILTIITVIESVGSFIWFLKWMGTNVFGTPSETVATAGKPPLAIKFVLAFLIIMTLISQYIALALLS
>Mature_479_residues
MVWYALGSILLPLVGSLVVLFLSEQQVKKAGQLFSFLAFLCGLALLVSFALTGESFSRELVAINGVTCYGITVDALSVLT
NFLVVLIGWLICTYSAGYMSPDNREHPICEGINRFYSLMLLFIGSMAGVVFSTTLLGLLFFFEITGICSWSLIGFYGDEK
SRKSALWAIALTHSAALGLYVATAYLYVKTGSFSVTALGKLTEAEKTIAFIGILIACWGKSAQLPFHPWLPRAMVAPTPV
SAYLHAASMVKVGVYIYARTVLAAGKVPAVIGQVGAIMAVITMIYGFIMYFPQQDMKRLLAYSTITQLSYIFLAISIFIL
GSQMAFKGGVAHIFNHAFGKSLFFLVAGALSYTTGTRKLLMFRGILKKMPVIGLGYIAASMAITGVPPFNGFFSKIMIII
SGFEISRHNLLILILTIITVIESVGSFIWFLKWMGTNVFGTPSETVATAGKPPLAIKFVLAFLIIMTLISQYIALALLS

Specific function: Unknown

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=348, Percent_Identity=30.1724137931034, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI251831116, Length=320, Percent_Identity=23.4375, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1788829, Length=471, Percent_Identity=51.8046709129512, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1788614, Length=429, Percent_Identity=31.7016317016317, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788827, Length=352, Percent_Identity=26.7045454545455, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788831, Length=350, Percent_Identity=30.8571428571429, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788613, Length=426, Percent_Identity=25.3521126760563, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI2367154, Length=192, Percent_Identity=30.2083333333333, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=415, Percent_Identity=25.5421686746988, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 51992; Mature: 51992

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWYALGSILLPLVGSLVVLFLSEQQVKKAGQLFSFLAFLCGLALLVSFALTGESFSREL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCE
VAINGVTCYGITVDALSVLTNFLVVLIGWLICTYSAGYMSPDNREHPICEGINRFYSLML
EEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
LFIGSMAGVVFSTTLLGLLFFFEITGICSWSLIGFYGDEKSRKSALWAIALTHSAALGLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHH
VATAYLYVKTGSFSVTALGKLTEAEKTIAFIGILIACWGKSAQLPFHPWLPRAMVAPTPV
HHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
SAYLHAASMVKVGVYIYARTVLAAGKVPAVIGQVGAIMAVITMIYGFIMYFPQQDMKRLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AYSTITQLSYIFLAISIFILGSQMAFKGGVAHIFNHAFGKSLFFLVAGALSYTTGTRKLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MFRGILKKMPVIGLGYIAASMAITGVPPFNGFFSKIMIIISGFEISRHNLLILILTIITV
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHH
IESVGSFIWFLKWMGTNVFGTPSETVATAGKPPLAIKFVLAFLIIMTLISQYIALALLS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVWYALGSILLPLVGSLVVLFLSEQQVKKAGQLFSFLAFLCGLALLVSFALTGESFSREL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCE
VAINGVTCYGITVDALSVLTNFLVVLIGWLICTYSAGYMSPDNREHPICEGINRFYSLML
EEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
LFIGSMAGVVFSTTLLGLLFFFEITGICSWSLIGFYGDEKSRKSALWAIALTHSAALGLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHH
VATAYLYVKTGSFSVTALGKLTEAEKTIAFIGILIACWGKSAQLPFHPWLPRAMVAPTPV
HHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
SAYLHAASMVKVGVYIYARTVLAAGKVPAVIGQVGAIMAVITMIYGFIMYFPQQDMKRLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AYSTITQLSYIFLAISIFILGSQMAFKGGVAHIFNHAFGKSLFFLVAGALSYTTGTRKLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MFRGILKKMPVIGLGYIAASMAITGVPPFNGFFSKIMIIISGFEISRHNLLILILTIITV
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHH
IESVGSFIWFLKWMGTNVFGTPSETVATAGKPPLAIKFVLAFLIIMTLISQYIALALLS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]