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The map label for this gene is pyrE

Identifier: 20807965

GI number: 20807965

Start: 1492597

End: 1493169

Strand: Reverse

Name: pyrE

Synonym: TTE1529

Alternate gene names: 20807965

Gene position: 1493169-1492597 (Counterclockwise)

Preceding gene: 20807966

Following gene: 20807962

Centisome position: 55.52

GC content: 37.35

Gene sequence:

>573_bases
ATGGAAAAAGAAAAGGTTTTGGAAATTTTTGAAAAACTAGAAGTTATAAATAAAGGGCATTTTCTGCTGAGTTCTGGGAA
ACACAGTGATACGTACCTTCAATGTGCAAAGATATTTCAATATCCTAACTATAGTGAAATTTTTAGCAGGGAATTGGCAG
AGAAGTTCAAAGGATACAGAATAGATGTGGTAATAGGCCCTGCGATTGGAGGCATTATATTGGCGTATGAGGTTGCGCGG
CAAATCGGTGTAAGAGCTTTATTTGCGGAAAGAGAAGACAATGTTATGAAGTTGAGAAGAGGATTTGAGATAAGTAAAGG
AGAAAGAGTATTGGTGGTAGAAGATGTAGTGACAACAGGAGGTTCTGTAAAAGAGGTAATAGAATTGGTCAGATCTTTAG
GAGGAGAAGTGATAGGAGTAGGAACTATTGTTGATAGAAGCGATGGGAAAATAGATTTTGGTGTGCCTTTTGAGTCAATT
GTAAAGTTACAGATTAAAACTTATGAAAAAGAGGAATGCCCTCTTTGTAAAGAGGGTATTCCTCTGGTAAAGCCAGGAAG
CAGAAAGCTTTAG

Upstream 100 bases:

>100_bases
TGAGATTATTGATGGAATAAAAAAGTACATGGAAGAAAACGAAATTGAAGACATAAATGAAATTATTGGAAGTATAAAAA
TTTAAAGAGGGGATTTGGAA

Downstream 100 bases:

>100_bases
GGCACTAACATCCTTATAACTTTCATCGTTTCAGGGCCCACAATGCCGTCTACTTTAAGGCCGTTGTCTCGCTGAAATTT
CATGACGGCCTTTTTTGTTC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MEKEKVLEIFEKLEVINKGHFLLSSGKHSDTYLQCAKIFQYPNYSEIFSRELAEKFKGYRIDVVIGPAIGGIILAYEVAR
QIGVRALFAEREDNVMKLRRGFEISKGERVLVVEDVVTTGGSVKEVIELVRSLGGEVIGVGTIVDRSDGKIDFGVPFESI
VKLQIKTYEKEECPLCKEGIPLVKPGSRKL

Sequences:

>Translated_190_residues
MEKEKVLEIFEKLEVINKGHFLLSSGKHSDTYLQCAKIFQYPNYSEIFSRELAEKFKGYRIDVVIGPAIGGIILAYEVAR
QIGVRALFAEREDNVMKLRRGFEISKGERVLVVEDVVTTGGSVKEVIELVRSLGGEVIGVGTIVDRSDGKIDFGVPFESI
VKLQIKTYEKEECPLCKEGIPLVKPGSRKL
>Mature_190_residues
MEKEKVLEIFEKLEVINKGHFLLSSGKHSDTYLQCAKIFQYPNYSEIFSRELAEKFKGYRIDVVIGPAIGGIILAYEVAR
QIGVRALFAEREDNVMKLRRGFEISKGERVLVVEDVVTTGGSVKEVIELVRSLGGEVIGVGTIVDRSDGKIDFGVPFESI
VKLQIKTYEKEECPLCKEGIPLVKPGSRKL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_THETN (P58858)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623136.1
- ProteinModelPortal:   P58858
- SMR:   P58858
- GeneID:   997965
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1529
- NMPDR:   fig|273068.3.peg.1483
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   TTEN273068:TTE1529-MONOMER
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 21251; Mature: 21251

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEKVLEIFEKLEVINKGHFLLSSGKHSDTYLQCAKIFQYPNYSEIFSRELAEKFKGYR
CCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
IDVVIGPAIGGIILAYEVARQIGVRALFAEREDNVMKLRRGFEISKGERVLVVEDVVTTG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEEHHHHCC
GSVKEVIELVRSLGGEVIGVGTIVDRSDGKIDFGVPFESIVKLQIKTYEKEECPLCKEGI
CCHHHHHHHHHHCCCCEEEEEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCC
PLVKPGSRKL
CCCCCCCCCC
>Mature Secondary Structure
MEKEKVLEIFEKLEVINKGHFLLSSGKHSDTYLQCAKIFQYPNYSEIFSRELAEKFKGYR
CCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
IDVVIGPAIGGIILAYEVARQIGVRALFAEREDNVMKLRRGFEISKGERVLVVEDVVTTG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEEHHHHCC
GSVKEVIELVRSLGGEVIGVGTIVDRSDGKIDFGVPFESIVKLQIKTYEKEECPLCKEGI
CCHHHHHHHHHHCCCCEEEEEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCC
PLVKPGSRKL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336