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The map label for this gene is PyrD

Identifier: 20807966

GI number: 20807966

Start: 1493185

End: 1494090

Strand: Reverse

Name: PyrD

Synonym: TTE1530

Alternate gene names: 20807966

Gene position: 1494090-1493185 (Counterclockwise)

Preceding gene: 20807967

Following gene: 20807965

Centisome position: 55.55

GC content: 38.85

Gene sequence:

>906_bases
TTGAACCTATCGGTTGAGATTGGAAAGATAAAGCTTAAAAACCCTGTGATTACTGCCTCAGGAACTTTTGGTTTTGGCAG
GGAGTACAGTGAATACATCGACCTTAATAAATTAGGAGCGATAGTTGTAAAAGGACTTACTGTAAAGCCAAGAGAAGGCA
ATCCTCCGCCCAGGTTGTTTGAGACCGCTTCTGGGATTTTAAACAGCATAGGCCTTCAAAATCCGGGAGTAGATGCGTTT
ATTGAAAGGGAACTTCCTTTTTTGAAAAGTTTCGATGTTCCAGTGATTGTAAATATTGCTGGGGAAACGGTTGAGGAATT
TGTGTATATGGCAGAAAAACTTGATATTGAAGGGATAGAAGGGATTGAAATTAACGTTTCCTGCCCCAACGTGAAAAAAG
GCGGAATGGCTTTTGGTGTAAATCCAGATGATATTTTTGACATTACAAGAAAGGTTAGAAAGGCTACCAGTAAGACTGTC
ATAGTGAAGTTAACCCCAAATGTAACAGACATAAAAGTTTGCGCAAAGGCTGCGGAAAAAGGAGGAGCAGATGCTATATC
TTTGATTAACACGGTGGCAGGGATGGCTGTAGACATCGATAAAAGGAGGCCTGTTTTTGAGAATGTAATTGGGGGGCTAT
CCGGGCCTGCTATAAAGCCTATTGCTCTTAAAATGGTGTACGAAGTAGTCACAGTTGTGAGCATTCCTGTGATAGGCATG
GGAGGAATAATGAACTACAAAGATGCTTTGGAATTTTTAATTGTAGGTGCAAGAGCTATTGCAGTGGGAACTTGTAATTT
TGTAAATCCTTACTGTACTGTTGAGATTATTGATGGAATAAAAAAGTACATGGAAGAAAACGAAATTGAAGACATAAATG
AAATTATTGGAAGTATAAAAATTTAA

Upstream 100 bases:

>100_bases
CCTGCCTTGGATGTGCGTGCAAGGTCAGAGAAGATAAAGGCTTTTCTTACAAGAGAGTTTGCAGAGATGGGCCGGTTTTC
TGGGCAGAGGAGGTGCTATT

Downstream 100 bases:

>100_bases
AGAGGGGATTTGGAAATGGAAAAAGAAAAGGTTTTGGAAATTTTTGAAAAACTAGAAGTTATAAATAAAGGGCATTTTCT
GCTGAGTTCTGGGAAACACA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLFETASGILNSIGLQNPGVDAF
IERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIEGIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTV
IVKLTPNVTDIKVCAKAAEKGGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGM
GGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIKI

Sequences:

>Translated_301_residues
MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLFETASGILNSIGLQNPGVDAF
IERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIEGIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTV
IVKLTPNVTDIKVCAKAAEKGGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGM
GGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIKI
>Mature_301_residues
MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLFETASGILNSIGLQNPGVDAF
IERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIEGIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTV
IVKLTPNVTDIKVCAKAAEKGGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGM
GGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIKI

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=341, Percent_Identity=29.3255131964809, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI45006951, Length=323, Percent_Identity=24.4582043343653, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082059, Length=320, Percent_Identity=28.75, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=189, Percent_Identity=31.7460317460317, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322633, Length=267, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640763, Length=185, Percent_Identity=35.6756756756757, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI18858217, Length=185, Percent_Identity=35.6756756756757, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_THETN (Q8R9R7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623137.1
- ProteinModelPortal:   Q8R9R7
- SMR:   Q8R9R7
- GeneID:   996616
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1530
- NMPDR:   fig|273068.3.peg.1484
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   PRK07259
- BioCyc:   TTEN273068:TTE1530-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32419; Mature: 32419

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLF
CCCEEEECEEEECCCEEEECCCCCCCCHHHHHHCHHHHHHHEEECCEECCCCCCCCHHHH
ETASGILNSIGLQNPGVDAFIERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIE
HHHHHHHHHCCCCCCCCCHHHHCCCCHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCC
GIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTVIVKLTPNVTDIKVCAKAAEK
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGM
CCHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIK
CCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
I
C
>Mature Secondary Structure
MNLSVEIGKIKLKNPVITASGTFGFGREYSEYIDLNKLGAIVVKGLTVKPREGNPPPRLF
CCCEEEECEEEECCCEEEECCCCCCCCHHHHHHCHHHHHHHEEECCEECCCCCCCCHHHH
ETASGILNSIGLQNPGVDAFIERELPFLKSFDVPVIVNIAGETVEEFVYMAEKLDIEGIE
HHHHHHHHHCCCCCCCCCHHHHCCCCHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCC
GIEINVSCPNVKKGGMAFGVNPDDIFDITRKVRKATSKTVIVKLTPNVTDIKVCAKAAEK
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GGADAISLINTVAGMAVDIDKRRPVFENVIGGLSGPAIKPIALKMVYEVVTVVSIPVIGM
CCHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GGIMNYKDALEFLIVGARAIAVGTCNFVNPYCTVEIIDGIKKYMEENEIEDINEIIGSIK
CCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336