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The map label for this gene is pyrH

Identifier: 20807854

GI number: 20807854

Start: 1390174

End: 1390887

Strand: Reverse

Name: pyrH

Synonym: TTE1407

Alternate gene names: 20807854

Gene position: 1390887-1390174 (Counterclockwise)

Preceding gene: 20807855

Following gene: 20807853

Centisome position: 51.72

GC content: 43.84

Gene sequence:

>714_bases
GTGTCATCAGTAGTGTATAAAAGAGTAGTTCTGAAAATCTCAGGGGAGGCCTTGGCCGGAGATAAGGAATTTGGAATAGA
CTTTAATGTAGTAAATAGAATTGCAGACGAGATAAAAGAAGTGAGAGACTTAGGAGTACAAATTGGTCTCGTGGTAGGAG
GCGGAAACATCTGGCGGGGCAGAGACGCTGTAGGGATGGACAGAACTACTGCAGACCACATGGGGATGCTTGCAACTGTC
ATAAACGCTCTGGCTCTACAGGATGCTTTAGAACAAAGGGGCGTACCTACAAGAGTGCAGACGGCAATAGAGATGAGGGC
CATTGCAGAACCTTATATCCGCAGAAGAGCCATAAGACACCTGGAAAAAGGGCGAGTAGTCATATTTGCAGCAGGCACAG
GTAATCCCTTTTTCTCGACAGACACTGCTGCTTCATTAAGAGCTGCTGAAATAGATGCAGAAGTAATACTGCTTGCTAAA
AAGGTGGACGGCGTTTATGACAAAGACCCTCTAAAGCACAAAGATGCTGTAAAGTTTAAAGAATTAAGTTATCTGGACGT
GTTAAACAAAGGATTGGGAGTCATGGATTCTACTGCAACTTCCCTCTGCATGGACAATAAAATCCCCATCATAGTGTTTG
ACCTGACCACATATGGAAACATTAAGAAAGTGGTAATGGGAAATGATATCGGTACGATTGTGAAGGAGGGTTAA

Upstream 100 bases:

>100_bases
ATAAAGGGACACTGATGTGTCCCCTTTTTATAGAAATTTCGAAATTTCAGAAGGATTTTTTGAAATTGTATAGAAACTTA
TATAAGAATGGGGTGTTATT

Downstream 100 bases:

>100_bases
CATGAGCGATTATTTGAAAGACAGTGAAGAGAGGATGAAGAAAACTTTAAACGTCTTAAAAAGCGAACTTGCGGCAATAC
GTGCTGGAAGAGCGAATCCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRGRDAVGMDRTTADHMGMLATV
INALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAK
KVDGVYDKDPLKHKDAVKFKELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG

Sequences:

>Translated_237_residues
MSSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRGRDAVGMDRTTADHMGMLATV
INALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAK
KVDGVYDKDPLKHKDAVKFKELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG
>Mature_236_residues
SSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRGRDAVGMDRTTADHMGMLATVI
NALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAKK
VDGVYDKDPLKHKDAVKFKELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=50, Blast_Score=234, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_THETN (Q8RA23)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623025.1
- ProteinModelPortal:   Q8RA23
- SMR:   Q8RA23
- GeneID:   996224
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1407
- NMPDR:   fig|273068.3.peg.1372
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   TTEN273068:TTE1407-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25789; Mature: 25658

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 72-72 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRG
CCCHHEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECC
RDAVGMDRTTADHMGMLATVINALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAKKVDGVYDKDPLKHKDAVKFK
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCCHHHH
ELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHEECC
>Mature Secondary Structure 
SSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRG
CCHHEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECC
RDAVGMDRTTADHMGMLATVINALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAKKVDGVYDKDPLKHKDAVKFK
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCCHHHH
ELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336