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The map label for this gene is rnhA

Identifier: 20807809

GI number: 20807809

Start: 1344849

End: 1345310

Strand: Direct

Name: rnhA

Synonym: TTE1362

Alternate gene names: 20807809

Gene position: 1344849-1345310 (Clockwise)

Preceding gene: 20807808

Following gene: 20807810

Centisome position: 50.0

GC content: 36.8

Gene sequence:

>462_bases
ATGAAAAATAATAACGAAATAGTAGAAATCTACACAGATGGGGCTTGCAGCGGCAATCCTGGACCAGGCGGCTGGGCGGC
AGTTTTGATATATAAAGGAATAAAAAAAGAAATATCAGGGTTTGAAGAAAACACCACAAATAACAGGATGGAATTAAAGG
CAGCCATTGAGGGTTTAAAGGCTTTAAAAAGGCCTTGTAAGGTGAATTTATATAGCGACAGCAGTTATTTAATAAACGCT
TTTAATGAGGGATGGATTGAAAAGTGGCAGAAGAACAACTGGCTTAAATCTGACAAAACTCCAGTAGAAAATCAGGACTT
ATGGAAAGAGTTATTAGAAGTTTCTAAACCGCATCAGATAAACTGGATTAAGGTTAAAGGTCATTCTGATAATGAGTACA
ACAACTTGTGCGACAGACTGGCCACAGAACAAATAAAAAAACACATAAAAGAGAATCCCTAA

Upstream 100 bases:

>100_bases
ACTATAGAAGGCATAAGAGTTTTGGAAAAAAGCGGTATGAGAAGTGCGGTGATTGAAGCTGTGATTGCAGCTTATCAGAA
GGCAAAAGGGCTGAAATAAA

Downstream 100 bases:

>100_bases
GTTTTGGGATTCTCTTTTAGTTTTTGTGCTTGATTTTTCCTTGTTTGTGTGGTACCATAGATTATGTAATTATACGAAAT
ATCTATTTCGTATAATTAGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKNNNEIVEIYTDGACSGNPGPGGWAAVLIYKGIKKEISGFEENTTNNRMELKAAIEGLKALKRPCKVNLYSDSSYLINA
FNEGWIEKWQKNNWLKSDKTPVENQDLWKELLEVSKPHQINWIKVKGHSDNEYNNLCDRLATEQIKKHIKENP

Sequences:

>Translated_153_residues
MKNNNEIVEIYTDGACSGNPGPGGWAAVLIYKGIKKEISGFEENTTNNRMELKAAIEGLKALKRPCKVNLYSDSSYLINA
FNEGWIEKWQKNNWLKSDKTPVENQDLWKELLEVSKPHQINWIKVKGHSDNEYNNLCDRLATEQIKKHIKENP
>Mature_153_residues
MKNNNEIVEIYTDGACSGNPGPGGWAAVLIYKGIKKEISGFEENTTNNRMELKAAIEGLKALKRPCKVNLYSDSSYLINA
FNEGWIEKWQKNNWLKSDKTPVENQDLWKELLEVSKPHQINWIKVKGHSDNEYNNLCDRLATEQIKKHIKENP

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=148, Percent_Identity=31.7567567567568, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786408, Length=134, Percent_Identity=50.7462686567164, Blast_Score=135, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI115532542, Length=165, Percent_Identity=30.9090909090909, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=31.5068493150685, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_THETN (Q8RA67)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622980.1
- ProteinModelPortal:   Q8RA67
- SMR:   Q8RA67
- GeneID:   997776
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1362
- NMPDR:   fig|273068.3.peg.121
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   TTEN273068:TTE1362-MONOMER
- BRENDA:   3.1.26.4
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 17561; Mature: 17561

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNNEIVEIYTDGACSGNPGPGGWAAVLIYKGIKKEISGFEENTTNNRMELKAAIEGLK
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALKRPCKVNLYSDSSYLINAFNEGWIEKWQKNNWLKSDKTPVENQDLWKELLEVSKPHQI
HHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
NWIKVKGHSDNEYNNLCDRLATEQIKKHIKENP
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNNNEIVEIYTDGACSGNPGPGGWAAVLIYKGIKKEISGFEENTTNNRMELKAAIEGLK
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ALKRPCKVNLYSDSSYLINAFNEGWIEKWQKNNWLKSDKTPVENQDLWKELLEVSKPHQI
HHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
NWIKVKGHSDNEYNNLCDRLATEQIKKHIKENP
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336