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The map label for this gene is ProC [H]

Identifier: 20807808

GI number: 20807808

Start: 1344053

End: 1344847

Strand: Direct

Name: ProC [H]

Synonym: TTE1361

Alternate gene names: 20807808

Gene position: 1344053-1344847 (Clockwise)

Preceding gene: 20807807

Following gene: 20807809

Centisome position: 49.98

GC content: 41.01

Gene sequence:

>795_bases
ATGAAAATTGGCTTTATAGGTGCCGGGAACATGGGCATGGCCCTTATAAAGGGTATTTTGAAGTCAGACTTTGTGGAAGC
AGAAGACTTGATACTTTATGACCCTGTAAGAGAAAAAGTAGAAGGATTGGAAAGAGAGTTTGGGACAGTTACTGCTAAAG
ACAATCTAGAATTAACTGAAAAATCGGATGTAGTAATAGTAGCGGTAAAGCCAAATGTTTACGATGAAGTGCTCAAGGAA
ATTAGAGAAAAAGTGACAGAGGAAAAAATAATAATCACGATAGCTCCAGGGATTACTATAGACCATGTAAAAAAGCTTTT
GGGCAGGGGGAAAATAGTTAGGACAATCCCTAATACTCCTGCGTTAATAGGAGAAGGCATAACGGCCGTTACATATTCCG
AAGAAGTAAAAGAAGAAGACAAAGAACTTGTGCGAAAGATTTTTAGCACTTGTGGAGAAATAGTGGAGATAGAAGAAAAG
TTAATAGATGTGGCAATGGCCGTGTCAAGTTGCAGCCCAGCCTTCGTATACATGTTTATAGAAGCCTTAGCAGACGGAGG
AGTCCTGCTGGGATTGCCAAGAGATGTAGCTTATAAACTGGCTTCTAAAGCGGTATCTGGAGCGGGAAGCATGGTATTTA
AGACAGGCTTTCATCCAGGACAGTTAAAAGACATGGTCACTTCTCCGGGGGGAACTACTATAGAAGGCATAAGAGTTTTG
GAAAAAAGCGGTATGAGAAGTGCGGTGATTGAAGCTGTGATTGCAGCTTATCAGAAGGCAAAAGGGCTGAAATAA

Upstream 100 bases:

>100_bases
GAAAGATGATAAGAAGGAGGAGTAAGATCAAAAAAACAGTATTAGGCCTAACTAATACTGTTTTTTTGAAATAATTTAAA
AAACAGGGGAGTTTTAAAGG

Downstream 100 bases:

>100_bases
AATGAAAAATAATAACGAAATAGTAGAAATCTACACAGATGGGGCTTGCAGCGGCAATCCTGGACCAGGCGGCTGGGCGG
CAGTTTTGATATATAAAGGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKIGFIGAGNMGMALIKGILKSDFVEAEDLILYDPVREKVEGLEREFGTVTAKDNLELTEKSDVVIVAVKPNVYDEVLKE
IREKVTEEKIIITIAPGITIDHVKKLLGRGKIVRTIPNTPALIGEGITAVTYSEEVKEEDKELVRKIFSTCGEIVEIEEK
LIDVAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVSGAGSMVFKTGFHPGQLKDMVTSPGGTTIEGIRVL
EKSGMRSAVIEAVIAAYQKAKGLK

Sequences:

>Translated_264_residues
MKIGFIGAGNMGMALIKGILKSDFVEAEDLILYDPVREKVEGLEREFGTVTAKDNLELTEKSDVVIVAVKPNVYDEVLKE
IREKVTEEKIIITIAPGITIDHVKKLLGRGKIVRTIPNTPALIGEGITAVTYSEEVKEEDKELVRKIFSTCGEIVEIEEK
LIDVAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVSGAGSMVFKTGFHPGQLKDMVTSPGGTTIEGIRVL
EKSGMRSAVIEAVIAAYQKAKGLK
>Mature_264_residues
MKIGFIGAGNMGMALIKGILKSDFVEAEDLILYDPVREKVEGLEREFGTVTAKDNLELTEKSDVVIVAVKPNVYDEVLKE
IREKVTEEKIIITIAPGITIDHVKKLLGRGKIVRTIPNTPALIGEGITAVTYSEEVKEEDKELVRKIFSTCGEIVEIEEK
LIDVAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVSGAGSMVFKTGFHPGQLKDMVTSPGGTTIEGIRVL
EKSGMRSAVIEAVIAAYQKAKGLK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=36.6666666666667, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=36.6666666666667, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=37.7777777777778, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=45.8333333333333, Blast_Score=234, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=41.06463878327, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17540664, Length=274, Percent_Identity=38.6861313868613, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320861, Length=280, Percent_Identity=32.8571428571429, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21358587, Length=255, Percent_Identity=40.3921568627451, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24648116, Length=269, Percent_Identity=36.0594795539033, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=41.566265060241, Blast_Score=141, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28502; Mature: 28502

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGAGNMGMALIKGILKSDFVEAEDLILYDPVREKVEGLEREFGTVTAKDNLELTE
CEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCEECCCCCEEEC
KSDVVIVAVKPNVYDEVLKEIREKVTEEKIIITIAPGITIDHVKKLLGRGKIVRTIPNTP
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCCC
ALIGEGITAVTYSEEVKEEDKELVRKIFSTCGEIVEIEEKLIDVAMAVSSCSPAFVYMFI
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EALADGGVLLGLPRDVAYKLASKAVSGAGSMVFKTGFHPGQLKDMVTSPGGTTIEGIRVL
HHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
EKSGMRSAVIEAVIAAYQKAKGLK
HHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGFIGAGNMGMALIKGILKSDFVEAEDLILYDPVREKVEGLEREFGTVTAKDNLELTE
CEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCEECCCCCEEEC
KSDVVIVAVKPNVYDEVLKEIREKVTEEKIIITIAPGITIDHVKKLLGRGKIVRTIPNTP
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCCC
ALIGEGITAVTYSEEVKEEDKELVRKIFSTCGEIVEIEEKLIDVAMAVSSCSPAFVYMFI
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EALADGGVLLGLPRDVAYKLASKAVSGAGSMVFKTGFHPGQLKDMVTSPGGTTIEGIRVL
HHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
EKSGMRSAVIEAVIAAYQKAKGLK
HHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]