Click here to switch to the map view.

The map label for this gene is AarF [C]

Identifier: 20807646

GI number: 20807646

Start: 1186973

End: 1188640

Strand: Direct

Name: AarF [C]

Synonym: TTE1190

Alternate gene names: 20807646

Gene position: 1186973-1188640 (Clockwise)

Preceding gene: 20807645

Following gene: 20807647

Centisome position: 44.13

GC content: 37.05

Gene sequence:

>1668_bases
ATGAGGATTCCTTTGTTTTTGCGAAATAGAGAGATTTACAAGAGATATAGAGACATTCTAAAGATTCTTACAAAAAATGG
ATTTGGGTTTATAGTGGACATTCTCTCAAGAGGCGGGCGCGTGCCTTTTTACCTTCTGAGAGGGCATGATGTAATGGAAA
TCGGGGAGCGAATAAGAAATACTCTGGAAGAATTAGGACCTACTTTTATAAAGTTGGGGCAGCTCATAAGCACCAGAGCT
GACCTCATTCCCCACGACATTTTAATAGAGCTTTCCAAACTGCAGGATGAAGTAGCTCCAGAGGAATTTGAGTCAATAAA
AAAGGTTTTAGAGAGCGAATTAGGGGGAAACATTGAGGAGTTTTTCAGTTATTTTGAAGAAAAACCTCTGGCTTCAGCCT
CCATCGGGCAGGTTTACAGAGCAAGGACTAAAGAAGGAAAAGATGTAGTAGTGAAGGTTCAAAGGCCTGAAGTAGATAAA
AAGATACATGCGGATGTTGTGATCCTTAAAAATATAGCCAGGATTTTGAACGAGAGAATAGTAGATTCTCCAGTAGATTT
TGTGGAAATAGTGGAAGAACTTACGGATTCTCTGCTAAATGAACTTGATTACACTCAGGAAGGCAATAATGCCGATAGGT
TTAGAGAAAATTTTAAAAATCAGGATTATATATACATACCTGAGGTGTACTGGGATTATACCACAAAAAGAGTGCTGACA
ATGGAGTACATAGACGGGATAAGCGTTAAAAATAAAGAAATTTTGCGGGAAAAGGGTTATGACCTTAAAAGAATTGCGAG
GAATGGTGCTTGGTCTATCTTCTTACAGGTGTATAAATACGGTCTTTTTCACGGAGACCTGCATCCAGGAAACATCTTAA
TAACAAAGGAAGGAAAAATATCCTATATAGATTTTGGCATTGTAGGGTATCTGGACAAATCTTCTCGTGAAGTTTTGATA
GAGCTTTTTAAGGCATTTGCAGAAAATGATACAGAAGAAGTAATTGAAATTCTCTCAGATATAGGGGCTATAAGGGCTGA
TACCAATTTAAGAAATTTAAAGGCTGACCTCGGGAGAATAATAAACTACTTTTACACTACTCCTCTTAAGAATATAAATG
TAAATGATTCTATGAGAAGGATTATGGGGGTTGTGTACAAGTACAAGCTCATGCTGCCTCCAGGTTTTACACTTTTACTG
AAGGCTTTGGCTACTGTAGAAGGGGTAGGGAGAGACTTAGACCCTGATTTTAGCATATCGGATGTGGCAAGAGATTTTGT
GAAAGAAATGTATCTAAAGAAAATAGATGTAAAAGAGGTCATCAAGGAAAATTATAAAGACCTTCATAAAACTTTAATTA
TACTAAGAAAATTTCCTTTAAGGCTTCAGAGCATAATGACAAAACTTATAAAGGATGACATAAAAGTCAGAATAAACATT
GATGAGAGCGAGAGCTTGCGATATGACCTCAATGTGATGATAAACAAAGTGATTGTGAGCATAATAGCTTCAGCTTTGAT
CGTCGGGTCTTCTCTGGTTTTGACTTACGGCGGTGGTTACAAAATTTTTGGTTACAATGCTATAGGATTTTTCGGATATG
TAATTGCTACCATGCTGAGTTTGTGGGTGTTTTACAGGATATTCATAGTAGAGAGGAAGAAAAAATAG

Upstream 100 bases:

>100_bases
GGCGGCTAAAGCTTAAAAAGGCTTATTACGAAATATGATAGCAGGATGACTCTTTTTTAAAAAAGAGCTCGTGCTGCTAT
ATTTTTATTGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GTCTTTCAGGTGAGATAGATGGATAAAATTTATAGATGGGTCGTAAGAGAAAGGGATTTAAAGAAGATAGAGGAATTAAA
GGTAAAGTACCATTTGGATG

Product: protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MRIPLFLRNREIYKRYRDILKILTKNGFGFIVDILSRGGRVPFYLLRGHDVMEIGERIRNTLEELGPTFIKLGQLISTRA
DLIPHDILIELSKLQDEVAPEEFESIKKVLESELGGNIEEFFSYFEEKPLASASIGQVYRARTKEGKDVVVKVQRPEVDK
KIHADVVILKNIARILNERIVDSPVDFVEIVEELTDSLLNELDYTQEGNNADRFRENFKNQDYIYIPEVYWDYTTKRVLT
MEYIDGISVKNKEILREKGYDLKRIARNGAWSIFLQVYKYGLFHGDLHPGNILITKEGKISYIDFGIVGYLDKSSREVLI
ELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRIINYFYTTPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLL
KALATVEGVGRDLDPDFSISDVARDFVKEMYLKKIDVKEVIKENYKDLHKTLIILRKFPLRLQSIMTKLIKDDIKVRINI
DESESLRYDLNVMINKVIVSIIASALIVGSSLVLTYGGGYKIFGYNAIGFFGYVIATMLSLWVFYRIFIVERKKK

Sequences:

>Translated_555_residues
MRIPLFLRNREIYKRYRDILKILTKNGFGFIVDILSRGGRVPFYLLRGHDVMEIGERIRNTLEELGPTFIKLGQLISTRA
DLIPHDILIELSKLQDEVAPEEFESIKKVLESELGGNIEEFFSYFEEKPLASASIGQVYRARTKEGKDVVVKVQRPEVDK
KIHADVVILKNIARILNERIVDSPVDFVEIVEELTDSLLNELDYTQEGNNADRFRENFKNQDYIYIPEVYWDYTTKRVLT
MEYIDGISVKNKEILREKGYDLKRIARNGAWSIFLQVYKYGLFHGDLHPGNILITKEGKISYIDFGIVGYLDKSSREVLI
ELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRIINYFYTTPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLL
KALATVEGVGRDLDPDFSISDVARDFVKEMYLKKIDVKEVIKENYKDLHKTLIILRKFPLRLQSIMTKLIKDDIKVRINI
DESESLRYDLNVMINKVIVSIIASALIVGSSLVLTYGGGYKIFGYNAIGFFGYVIATMLSLWVFYRIFIVERKKK
>Mature_555_residues
MRIPLFLRNREIYKRYRDILKILTKNGFGFIVDILSRGGRVPFYLLRGHDVMEIGERIRNTLEELGPTFIKLGQLISTRA
DLIPHDILIELSKLQDEVAPEEFESIKKVLESELGGNIEEFFSYFEEKPLASASIGQVYRARTKEGKDVVVKVQRPEVDK
KIHADVVILKNIARILNERIVDSPVDFVEIVEELTDSLLNELDYTQEGNNADRFRENFKNQDYIYIPEVYWDYTTKRVLT
MEYIDGISVKNKEILREKGYDLKRIARNGAWSIFLQVYKYGLFHGDLHPGNILITKEGKISYIDFGIVGYLDKSSREVLI
ELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRIINYFYTTPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLL
KALATVEGVGRDLDPDFSISDVARDFVKEMYLKKIDVKEVIKENYKDLHKTLIILRKFPLRLQSIMTKLIKDDIKVRINI
DESESLRYDLNVMINKVIVSIIASALIVGSSLVLTYGGGYKIFGYNAIGFFGYVIATMLSLWVFYRIFIVERKKK

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=281, Percent_Identity=28.8256227758007, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI41393593, Length=264, Percent_Identity=28.4090909090909, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=27.5985663082437, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI34147522, Length=287, Percent_Identity=28.9198606271777, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI32261307, Length=315, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI27363457, Length=351, Percent_Identity=25.0712250712251, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI217416386, Length=302, Percent_Identity=25.8278145695364, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI2367309, Length=407, Percent_Identity=36.1179361179361, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17559152, Length=282, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32565180, Length=361, Percent_Identity=25.207756232687, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17555620, Length=478, Percent_Identity=23.2217573221757, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=24.2494226327945, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323282, Length=248, Percent_Identity=30.241935483871, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=254, Percent_Identity=26.7716535433071, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24662575, Length=279, Percent_Identity=31.1827956989247, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI22024280, Length=228, Percent_Identity=32.8947368421053, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI18859849, Length=359, Percent_Identity=23.9554317548747, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 64150; Mature: 64150

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50011 PROTEIN_KINASE_DOM ; PS50290 PI3_4_KINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPLFLRNREIYKRYRDILKILTKNGFGFIVDILSRGGRVPFYLLRGHDVMEIGERIRN
CCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
TLEELGPTFIKLGQLISTRADLIPHDILIELSKLQDEVAPEEFESIKKVLESELGGNIEE
HHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
FFSYFEEKPLASASIGQVYRARTKEGKDVVVKVQRPEVDKKIHADVVILKNIARILNERI
HHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
VDSPVDFVEIVEELTDSLLNELDYTQEGNNADRFRENFKNQDYIYIPEVYWDYTTKRVLT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEECHHHHCCHHHHEEE
MEYIDGISVKNKEILREKGYDLKRIARNGAWSIFLQVYKYGLFHGDLHPGNILITKEGKI
HHHHCCCCCCHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCE
SYIDFGIVGYLDKSSREVLIELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRI
EEEEEHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
INYFYTTPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLLKALATVEGVGRDLDPDFSIS
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
DVARDFVKEMYLKKIDVKEVIKENYKDLHKTLIILRKFPLRLQSIMTKLIKDDIKVRINI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DESESLRYDLNVMINKVIVSIIASALIVGSSLVLTYGGGYKIFGYNAIGFFGYVIATMLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECHHHHHHHHHHHHHHH
LWVFYRIFIVERKKK
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIPLFLRNREIYKRYRDILKILTKNGFGFIVDILSRGGRVPFYLLRGHDVMEIGERIRN
CCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
TLEELGPTFIKLGQLISTRADLIPHDILIELSKLQDEVAPEEFESIKKVLESELGGNIEE
HHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
FFSYFEEKPLASASIGQVYRARTKEGKDVVVKVQRPEVDKKIHADVVILKNIARILNERI
HHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
VDSPVDFVEIVEELTDSLLNELDYTQEGNNADRFRENFKNQDYIYIPEVYWDYTTKRVLT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEECHHHHCCHHHHEEE
MEYIDGISVKNKEILREKGYDLKRIARNGAWSIFLQVYKYGLFHGDLHPGNILITKEGKI
HHHHCCCCCCHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCE
SYIDFGIVGYLDKSSREVLIELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRI
EEEEEHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
INYFYTTPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLLKALATVEGVGRDLDPDFSIS
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
DVARDFVKEMYLKKIDVKEVIKENYKDLHKTLIILRKFPLRLQSIMTKLIKDDIKVRINI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DESESLRYDLNVMINKVIVSIIASALIVGSSLVLTYGGGYKIFGYNAIGFFGYVIATMLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECHHHHHHHHHHHHHHH
LWVFYRIFIVERKKK
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]