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The map label for this gene is GcvP

Identifier: 20806814

GI number: 20806814

Start: 308588

End: 310045

Strand: Reverse

Name: GcvP

Synonym: TTE0293

Alternate gene names: 20806814

Gene position: 310045-308588 (Counterclockwise)

Preceding gene: 20806815

Following gene: 20806805

Centisome position: 11.53

GC content: 42.87

Gene sequence:

>1458_bases
ATGTTAAAAGAGTACAACAGCCTCATATTTGAACTTTCAAAAGAGGGAAAAAAGGCTTATACTCTTCCACCCCTTGATGT
GGAAGAAAAGCCTTTAGAAGATATGCTCCCTAAGGAAATGCTCAGAGAAAAAGAAGTGGATTTACCCGAAGTGAGCGAAG
TTGACGTAATAAGGCATTACACTCTTCTATCCCAGAAAAACTATGGTGTAGATATCGGATTTTACCCATTAGGCTCCTGT
ACTATGAAATACAATCCCAAGATTAATGAAGACATGGCTTCTCTTCCCGGCTTTACAGAACTTCACCCGTATCAGCCGGA
AGAAACCGTGCAAGGCGCATTAAAGCTCATGTACGAGCTAGAAAAGGCTCTTTGCGAAATCACAGGTATGGATAGATTTT
CACTGCATCCTGCAGCAGGAGCCCACGGCGAACTCACAGGTTTGATGATAATAAAAGCATATCACGAGCACAGGAATGAT
AAAAAGCGCAAAAAAATAATAGTACCAGATTCTGCTCACGGTACAAATCCAGCCAGTGCAGCAGTTGCTGGCTTTGATGT
GATTGAAATAAAGTCAAATAAAGAAGGGGCCATAGACCTAGAAGCATTAAAAGCGGTTTTAAATGATGAAGTAGCTGGCC
TCATGCTCACAAACCCAAGCACGCTAGGCCTCTTTGAGGAAAACATTGTGGAAATAGCAAGACTCGTGCATGAAGCAGGC
GGACTCCTTTATTACGATGGTGCTAACCTAAATGCAATAATGGGAATAAGCCGTCCTGGAGATATGGGATTTGACGTAGT
GCATCTAAACCTCCATAAAACTTTCTCAACTCCTCATGGAGGTGGCGGTCCTGGTTCCGGCCCTGTAGGAGTCAAAAAAG
AATTGGCAGATTTCTTACCTGTCCCAACTGTAGAAGAAAAAGATGGCAGATACTTCCTCGACTACGATAGACCACTTTCA
ATAGGAAAAGTGAGAAGCTTCTACGGCAACTTCAATGTGATGATAAAGGCATACTCTTACATCCTCACAATGGGAGCTGA
GGGATTAAAGAGGGCAAGTGAACTGGCAGTATTAAATGCCAATTACTTAAAAGAAAAACTAAAAGGGTATTACAAAGTGG
CAGTAGATAAGACTTGCATGCACGAATTTGTACTGGCAGGACTCGCCGAAAAATCAGGTGATGTGAGGACACTCGATGTG
GCAAAAAGGCTCATAGACTACGGCTTCCATCCGCCAACCATATACTTCCCTCTGATCGTGGAAGAAGCTCTCATGATAGA
GCCTACAGAGACAGAAACTAAAGAAACGCTGGACGCTTTCGCAGAAACGCTTATAAAAATAGCTAAAGAGGCAAAAGAAA
ATCCAGAGCTTTTGAAAGAGGCTCCTCACAACACTCCTGTAAGAAGGCTTGATGAAGTGCTGGCTGCTAGAAATCCTGTC
ATCAGGTGGACAAAATAA

Upstream 100 bases:

>100_bases
GATTACGAAAAGTACAAAAATGTCATGTTGCTTGCATTTACTGAAAAGAGGACAAAAGAAGAAATTGATAGGTTAAAATC
TCTCCTGGAGGTGATGTAGG

Downstream 100 bases:

>100_bases
AGGAGGACCATCGAGAGAAGCTGGGGGATATAAAAAAGCGGGGTTTTTGCCCCCGCTTTTTATCTTCCTCTGCTTCTAGT
TGCCACATCGAATATCACAG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLKEYNSLIFELSKEGKKAYTLPPLDVEEKPLEDMLPKEMLREKEVDLPEVSEVDVIRHYTLLSQKNYGVDIGFYPLGSC
TMKYNPKINEDMASLPGFTELHPYQPEETVQGALKLMYELEKALCEITGMDRFSLHPAAGAHGELTGLMIIKAYHEHRND
KKRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNDEVAGLMLTNPSTLGLFEENIVEIARLVHEAG
GLLYYDGANLNAIMGISRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPTVEEKDGRYFLDYDRPLS
IGKVRSFYGNFNVMIKAYSYILTMGAEGLKRASELAVLNANYLKEKLKGYYKVAVDKTCMHEFVLAGLAEKSGDVRTLDV
AKRLIDYGFHPPTIYFPLIVEEALMIEPTETETKETLDAFAETLIKIAKEAKENPELLKEAPHNTPVRRLDEVLAARNPV
IRWTK

Sequences:

>Translated_485_residues
MLKEYNSLIFELSKEGKKAYTLPPLDVEEKPLEDMLPKEMLREKEVDLPEVSEVDVIRHYTLLSQKNYGVDIGFYPLGSC
TMKYNPKINEDMASLPGFTELHPYQPEETVQGALKLMYELEKALCEITGMDRFSLHPAAGAHGELTGLMIIKAYHEHRND
KKRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNDEVAGLMLTNPSTLGLFEENIVEIARLVHEAG
GLLYYDGANLNAIMGISRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPTVEEKDGRYFLDYDRPLS
IGKVRSFYGNFNVMIKAYSYILTMGAEGLKRASELAVLNANYLKEKLKGYYKVAVDKTCMHEFVLAGLAEKSGDVRTLDV
AKRLIDYGFHPPTIYFPLIVEEALMIEPTETETKETLDAFAETLIKIAKEAKENPELLKEAPHNTPVRRLDEVLAARNPV
IRWTK
>Mature_485_residues
MLKEYNSLIFELSKEGKKAYTLPPLDVEEKPLEDMLPKEMLREKEVDLPEVSEVDVIRHYTLLSQKNYGVDIGFYPLGSC
TMKYNPKINEDMASLPGFTELHPYQPEETVQGALKLMYELEKALCEITGMDRFSLHPAAGAHGELTGLMIIKAYHEHRND
KKRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNDEVAGLMLTNPSTLGLFEENIVEIARLVHEAG
GLLYYDGANLNAIMGISRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPTVEEKDGRYFLDYDRPLS
IGKVRSFYGNFNVMIKAYSYILTMGAEGLKRASELAVLNANYLKEKLKGYYKVAVDKTCMHEFVLAGLAEKSGDVRTLDV
AKRLIDYGFHPPTIYFPLIVEEALMIEPTETETKETLDAFAETLIKIAKEAKENPELLKEAPHNTPVRRLDEVLAARNPV
IRWTK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=42.5581395348837, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1789269, Length=447, Percent_Identity=42.2818791946309, Blast_Score=300, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17535605, Length=427, Percent_Identity=43.3255269320843, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI32564013, Length=385, Percent_Identity=44.4155844155844, Blast_Score=286, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323843, Length=473, Percent_Identity=41.4376321353066, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24645648, Length=433, Percent_Identity=45.0346420323326, Blast_Score=319, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_THETN (Q8RCW2)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621985.1
- ProteinModelPortal:   Q8RCW2
- GeneID:   996270
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0293
- NMPDR:   fig|273068.3.peg.1221
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   TTEN273068:TTE0293-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 53939; Mature: 53939

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEYNSLIFELSKEGKKAYTLPPLDVEEKPLEDMLPKEMLREKEVDLPEVSEVDVIRHY
CCCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLLSQKNYGVDIGFYPLGSCTMKYNPKINEDMASLPGFTELHPYQPEETVQGALKLMYEL
HHHCCCCCCEEEEEEECCCEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EKALCEITGMDRFSLHPAAGAHGELTGLMIIKAYHEHRNDKKRKKIIVPDSAHGTNPASA
HHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHH
AVAGFDVIEIKSNKEGAIDLEALKAVLNDEVAGLMLTNPSTLGLFEENIVEIARLVHEAG
HHCCCEEEEEECCCCCCEEHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
GLLYYDGANLNAIMGISRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLP
CEEEECCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
VPTVEEKDGRYFLDYDRPLSIGKVRSFYGNFNVMIKAYSYILTMGAEGLKRASELAVLNA
CCCCCCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHEEECH
NYLKEKLKGYYKVAVDKTCMHEFVLAGLAEKSGDVRTLDVAKRLIDYGFHPPTIYFPLIV
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCEEEHHHHH
EEALMIEPTETETKETLDAFAETLIKIAKEAKENPELLKEAPHNTPVRRLDEVLAARNPV
HHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCC
IRWTK
EEECC
>Mature Secondary Structure
MLKEYNSLIFELSKEGKKAYTLPPLDVEEKPLEDMLPKEMLREKEVDLPEVSEVDVIRHY
CCCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLLSQKNYGVDIGFYPLGSCTMKYNPKINEDMASLPGFTELHPYQPEETVQGALKLMYEL
HHHCCCCCCEEEEEEECCCEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EKALCEITGMDRFSLHPAAGAHGELTGLMIIKAYHEHRNDKKRKKIIVPDSAHGTNPASA
HHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHH
AVAGFDVIEIKSNKEGAIDLEALKAVLNDEVAGLMLTNPSTLGLFEENIVEIARLVHEAG
HHCCCEEEEEECCCCCCEEHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
GLLYYDGANLNAIMGISRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLP
CEEEECCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
VPTVEEKDGRYFLDYDRPLSIGKVRSFYGNFNVMIKAYSYILTMGAEGLKRASELAVLNA
CCCCCCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHEEECH
NYLKEKLKGYYKVAVDKTCMHEFVLAGLAEKSGDVRTLDVAKRLIDYGFHPPTIYFPLIV
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCEEEHHHHH
EEALMIEPTETETKETLDAFAETLIKIAKEAKENPELLKEAPHNTPVRRLDEVLAARNPV
HHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCC
IRWTK
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336