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The map label for this gene is hppA

Identifier: 20806805

GI number: 20806805

Start: 295775

End: 297910

Strand: Reverse

Name: hppA

Synonym: TTE0284

Alternate gene names: 20806805

Gene position: 297910-295775 (Counterclockwise)

Preceding gene: 20806814

Following gene: 20806804

Centisome position: 11.08

GC content: 44.76

Gene sequence:

>2136_bases
TTGGGTGCCTATCTTACACTAATTTACGGAGTTATAGTTATTGCAGCCCTTGTGATAATTGGTTTGATTAAATTTATATT
CGCTCAGGATAAAGGCAATGAAAAGATGCAGCAGATCTCCGACGCAATCAAAGAAGGAGCAATGGCTTTCCTAAACAGGC
AATATAAGACAATAGCTTCTCTAGCTTTAATAGTAGCAGTAATAATCGTAGTGGCTAACTACTACGGGCATCTGTCTGAA
GGAAGTAGCCAAGCACTTAGCTTTGCACTGCATGTTGGTTTTGCCTTTATCACTGGAGCGTTTTGTTCCGCCTTGTCCGG
CTATATCGGAATGTATATGGCGGTAAATTCGAATATAAGGGCTGCAGCTGGTGCAAGGTCAGGTCTTAACAGAGCTCTTC
AAATTGCCTTAAAGGGAGGAGCTGTGACAGGTCTTGCAGTTACAGCTTTGTCTTTATTTGGAGTTGCTACCTTATTTTTG
GCATATGGCGGTCTGTCAGGACAGGATGAGCTCATAAAAGAAGCTCCTTCTCTCATTGTCGGCTTTGGGTTTGGAGCTTC
ATTTGTAGCTTTGTTTGCCCAGCTGGGCGGTGGTATATATACAAAGGCTGCCGACGTGGGAGCTGACCTCGTAGGAAAAG
TAGAAGCAGGAATTCCTGAAGATGACCCCAGAAACCCTGCAGTCATAGCCGACCTCGTGGGAGACAACGTAGGAGACTGC
GCAGGAAGAGGTGCAGACCTTTTTGAATCCACCGCCGCTGAAAACATCGGTGCAATGATATTGGGAGTTGGACTTTACCC
AATCTTCGGGTGGAAAGGAATTTTATTCCCACTGGTAGCCCGTGCAATAGGTATAATTGCCTCTATAATAGGCATATTCT
TTGTAAACACAAAAGACGAATCAAAAGACCCAATGATAGCTTTAAACAAGGGTTACTTTGTAACAACTGTAGTAAACTTA
ATAGCCCTCTTCTTTGCAGTAAAAGTGATGCTTTCAGGGCATTTGCCTGACGGACGCCCTGTCAATTACTTGCTTCTTTA
CGGAGCAGTAGTGACAGGTGTCATCTTAAGCTACATTTTCGTCTTCCTCACAGACTACTACACTTCTGTCAACAAACGCC
CTGTTCAAGAAATCGCCAAAGCTTCTACAACAGGTGCAGCCACAAACATCATAACCGGTACATCTGTGGGCATGGAATCG
ACAGCTCTACCTGTCATATTCATATCAGCAGCAATATACATAGCCTACAAGCTCGGAGAAATGGCAATACCTCACATAGG
AACAGCAGGGCTTTACGGCACAGCTATTGCTACAATGGGAATGCTGTCTACAACTGCATATATACTAGCCATGGACACGT
TTGGTCCAATCACTGACAATGCAGGCGGAATCACTGAAATGTCCGGAGCCCCTGAAGAGATAAGAAGGGTTACAGACAGG
TTAGATGCCTGCGGAAACACGACTAAAGCCTTGACAAAAGGATACGCAATTGGCTCTGCGGCTTTGGCTACTTTCTTGCT
TTTCTCTGCTTATCTTGACGAAGTAAAGAAAATACTCGGCAAGCCAATAGACTCATGGTTCCCAGTAGACATAGGAAAGC
CAGAAGTCTTCATAGGAGCATTCATAGGGGCGATGATCGTGTATCTATTCAGCTCTACCGCCATAAGGGCTGTAGGAAAA
GCCGCACAGTATGTAATCCTCGAAGTGAGAAGGCAGTTCAGAGAAATACCTGGTATCATGGAAGGAACAGCAAAACCAGA
CTATGCAAGAGCAGTAGACATCGTAACAAAAGGTGCTCTAAAAGAAATGGTAATACCGGGTCTCATAGTTGTTGTCACTC
CAATACTTGTCGGTGTAATTTTAGGCAAAGAGGCGGCTGCAGCCTTCTTGATGATTGGCACAATTTCCGGTGTAATTCTC
GCCCTTTACCTCAATAACGGCGGAGGAGCATGGGATAACGCCAAAAAGTTTATAGAACTAGGTAATTATGGCGGCAAAGG
TTCAGACGCTCACAAAGCCAGCGTTGTAGGAGACACTGTAGGAGACCCCTTCAAAGACACAGCTGGTCCATCTCTGCACG
TTTTGATAAAACTCATAAGCACGATAACACTGGTGTTTGTAGCCTTGTTCAGATAA

Upstream 100 bases:

>100_bases
TTCTTTCCGTTCATTTTGAAAATAGTTGAAGGAATTTTTAAAAGTTTGTCGAAATAGTAATGAGTAGCGATAAAAACAAC
AAAGAAAGGGAGGATAAAAG

Downstream 100 bases:

>100_bases
AAATTTTGTAAAGGAAGTGGTCAAATGGGATATAAAGAAGTAACACCAAAAAGGCGCCTCATGGGGAGGTTTCCCCATGG
GAGCGACCTCCTTCAAGAAA

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MGAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIASLALIVAVIIVVANYYGHLSE
GSSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIRAAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFL
AYGGLSGQDELIKEAPSLIVGFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDC
AGRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDESKDPMIALNKGYFVTTVVNL
IALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIFVFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMES
TALPVIFISAAIYIAYKLGEMAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDR
LDACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGAFIGAMIVYLFSSTAIRAVGK
AAQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGALKEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVIL
ALYLNNGGGAWDNAKKFIELGNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR

Sequences:

>Translated_711_residues
MGAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIASLALIVAVIIVVANYYGHLSE
GSSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIRAAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFL
AYGGLSGQDELIKEAPSLIVGFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDC
AGRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDESKDPMIALNKGYFVTTVVNL
IALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIFVFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMES
TALPVIFISAAIYIAYKLGEMAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDR
LDACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGAFIGAMIVYLFSSTAIRAVGK
AAQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGALKEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVIL
ALYLNNGGGAWDNAKKFIELGNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR
>Mature_710_residues
GAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIASLALIVAVIIVVANYYGHLSEG
SSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIRAAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFLA
YGGLSGQDELIKEAPSLIVGFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCA
GRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDESKDPMIALNKGYFVTTVVNLI
ALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIFVFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMEST
ALPVIFISAAIYIAYKLGEMAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDRL
DACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGAFIGAMIVYLFSSTAIRAVGKA
AQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGALKEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVILA
LYLNNGGGAWDNAKKFIELGNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_THETN (Q8RCX1)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621976.1
- GeneID:   997931
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0284
- NMPDR:   fig|273068.3.peg.1212
- HOGENOM:   HBG593668
- OMA:   AENIGAM
- ProtClustDB:   PRK00733
- BioCyc:   TTEN273068:TTE0284-MONOMER
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 74382; Mature: 74251

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xc7fa26c)-; HASH(0xc284ae8)-; HASH(0xc656090)-; HASH(0xc71c3d4)-; HASH(0xc0c95f8)-; HASH(0xca37130)-; HASH(0xca2abec)-; HASH(0xc0d03b4)-; HASH(0xc0f54d4)-; HASH(0xca12324)-; HASH(0xca2ceb4)-; HASH(0xc872cd4)-; HASH(0xb157714)-; HASH(0xb440304)-; HASH(0xb24ceb0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALIVAVIIVVANYYGHLSEGSSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
AAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFLAYGGLSGQDELIKEAPSLIV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEE
GFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDC
ECCCHHHHHHHHHHHCCCCEEHHHHHCHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCHH
AGRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SKDPMIALNKGYFVTTVVNLIALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIF
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMESTALPVIFISAAIYIAYKLGE
HHHHHHHHHCCCCHHHHHHHCCCCCCHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
MAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
FIGAMIVYLFSSTAIRAVGKAAQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHH
KEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVILALYLNNGGGAWDNAKKFIEL
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
GNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure 
GAYLTLIYGVIVIAALVIIGLIKFIFAQDKGNEKMQQISDAIKEGAMAFLNRQYKTIAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALIVAVIIVVANYYGHLSEGSSQALSFALHVGFAFITGAFCSALSGYIGMYMAVNSNIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
AAAGARSGLNRALQIALKGGAVTGLAVTALSLFGVATLFLAYGGLSGQDELIKEAPSLIV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEE
GFGFGASFVALFAQLGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDC
ECCCHHHHHHHHHHHCCCCEEHHHHHCHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCHH
AGRGADLFESTAAENIGAMILGVGLYPIFGWKGILFPLVARAIGIIASIIGIFFVNTKDE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SKDPMIALNKGYFVTTVVNLIALFFAVKVMLSGHLPDGRPVNYLLLYGAVVTGVILSYIF
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VFLTDYYTSVNKRPVQEIAKASTTGAATNIITGTSVGMESTALPVIFISAAIYIAYKLGE
HHHHHHHHHCCCCHHHHHHHCCCCCCHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
MAIPHIGTAGLYGTAIATMGMLSTTAYILAMDTFGPITDNAGGITEMSGAPEEIRRVTDR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDACGNTTKALTKGYAIGSAALATFLLFSAYLDEVKKILGKPIDSWFPVDIGKPEVFIGA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
FIGAMIVYLFSSTAIRAVGKAAQYVILEVRRQFREIPGIMEGTAKPDYARAVDIVTKGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHH
KEMVIPGLIVVVTPILVGVILGKEAAAAFLMIGTISGVILALYLNNGGGAWDNAKKFIEL
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
GNYGGKGSDAHKASVVGDTVGDPFKDTAGPSLHVLIKLISTITLVFVALFR
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336