Click here to switch to the map view.

The map label for this gene is GcvP2

Identifier: 20806815

GI number: 20806815

Start: 310047

End: 311396

Strand: Reverse

Name: GcvP2

Synonym: TTE0294

Alternate gene names: 20806815

Gene position: 311396-310047 (Counterclockwise)

Preceding gene: 20806816

Following gene: 20806814

Centisome position: 11.58

GC content: 40.74

Gene sequence:

>1350_bases
GTGATAGTTATGTTTCCGTATCTCCCCATCTCCTCCGAAGATGAAAAGGAAATGCTAAAAACCATAGGAAAAAACTCTAT
TGAAGAATTATTTGAAGTCATCCCAAAAGAGGTTAGGCTAAATCGCCCCTTAAATTTGGGAAAACCCATGTCAGAGCTGG
AGGTTAGAAAGCGCTTAGGAAGTTATGCAGATGAGAATAAAAATTTAAGCCAGCTTGTGAGCTTTTTAGGCGCAGGAGTG
TATGACCACTACATCCCTTCTGTTGTAAAACACATAATCTCAAGGTCAGAATTCTACACGGCTTACACCCCATACCAGCC
AGAAATAAGCCAGGGAACACTTCAAGCCATTTTTGAATACCAGACGATGATAACAAACCTCACGGGAATGGAAGTCACCA
ACGCTTCCATGTACGATGGAGCAAGCGCCTGTGCAGAGGCTGCAATGATGGCCTGTGACGCTACAAAAAGGAAATCTATA
ATAGTGTCAAAGACTGTAAATCCAGAGACAAGAAAGGTTTTAAAAACCTATATGCATTTTAAAGAAGTGGAAGTAGTAGA
AATAGAAGATGCGGATGGAGTAACTGACATTGAAAAATTAAAAGAAGTGATTGGCCCAAACACCGCAGCAGTCATAGTAC
AGTACCCCAACTTCTTTGGGATAATTGAAAACTTGCAGGAGATTGAAAAAATAACCCACGAACAAAAGGCCATGCTCATC
ACCTATGTACATCCAATACCTCTGGGAATTTTAAAATCACCTGGAGAAATCGGTGCAGACATAGCAGTAGGAGACGGTCA
ATCCCTTGGAAATGGACTCCATTACGGAGGACCGTACTTGGGATTTCTGGCAACTACTCAGAAGCTTCTTCGCAGAATGC
CTGGAAGAATAGTAGGTCAGACAAAAGATGTAGACGGGAAAAGAGGATTTGTCCTCACCCTACAAGCAAGAGAACAGCAT
ATAAGAAGGGAGAAGGCAACTTCTAACATATGCTCTAACCATTCTCTAAATGCTTTAACTGCTGCAGTATATCTCGCTAC
AATAGGCAAAAAAGGGATTAAGGAAGTAGCTTACCAGTGCTTGCAAAAAGCTCATTATGCTTATACAGTGCTCACTGAGT
CAGGCAAGTATAAACCAGCTTTTAACAAACCTTTCTTCATGGAATTTGCTCTTAAAACAGACAAAGATGTAGCCGAAATA
AACAAAAAGCTTTTAGAAGAAGGGATACTGGGCGGTTACGACCTCCAGAGAGATTACGAAAAGTACAAAAATGTCATGTT
GCTTGCATTTACTGAAAAGAGGACAAAAGAAGAAATTGATAGGTTAAAATCTCTCCTGGAGGTGATGTAG

Upstream 100 bases:

>100_bases
ACCCATATGGAAGCTGGATGGTGATAGCAGAGCTTAAAGACAAATCTCAGTTAGATAAACTAATGAAGGCCGATGAGTAC
AGAAAATTCTTAGAGGAGGA

Downstream 100 bases:

>100_bases
GATGTTAAAAGAGTACAACAGCCTCATATTTGAACTTTCAAAAGAGGGAAAAAAGGCTTATACTCTTCCACCCCTTGATG
TGGAAGAAAAGCCTTTAGAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIVMFPYLPISSEDEKEMLKTIGKNSIEELFEVIPKEVRLNRPLNLGKPMSELEVRKRLGSYADENKNLSQLVSFLGAGV
YDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITNLTGMEVTNASMYDGASACAEAAMMACDATKRKSI
IVSKTVNPETRKVLKTYMHFKEVEVVEIEDADGVTDIEKLKEVIGPNTAAVIVQYPNFFGIIENLQEIEKITHEQKAMLI
TYVHPIPLGILKSPGEIGADIAVGDGQSLGNGLHYGGPYLGFLATTQKLLRRMPGRIVGQTKDVDGKRGFVLTLQAREQH
IRREKATSNICSNHSLNALTAAVYLATIGKKGIKEVAYQCLQKAHYAYTVLTESGKYKPAFNKPFFMEFALKTDKDVAEI
NKKLLEEGILGGYDLQRDYEKYKNVMLLAFTEKRTKEEIDRLKSLLEVM

Sequences:

>Translated_449_residues
MIVMFPYLPISSEDEKEMLKTIGKNSIEELFEVIPKEVRLNRPLNLGKPMSELEVRKRLGSYADENKNLSQLVSFLGAGV
YDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITNLTGMEVTNASMYDGASACAEAAMMACDATKRKSI
IVSKTVNPETRKVLKTYMHFKEVEVVEIEDADGVTDIEKLKEVIGPNTAAVIVQYPNFFGIIENLQEIEKITHEQKAMLI
TYVHPIPLGILKSPGEIGADIAVGDGQSLGNGLHYGGPYLGFLATTQKLLRRMPGRIVGQTKDVDGKRGFVLTLQAREQH
IRREKATSNICSNHSLNALTAAVYLATIGKKGIKEVAYQCLQKAHYAYTVLTESGKYKPAFNKPFFMEFALKTDKDVAEI
NKKLLEEGILGGYDLQRDYEKYKNVMLLAFTEKRTKEEIDRLKSLLEVM
>Mature_449_residues
MIVMFPYLPISSEDEKEMLKTIGKNSIEELFEVIPKEVRLNRPLNLGKPMSELEVRKRLGSYADENKNLSQLVSFLGAGV
YDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITNLTGMEVTNASMYDGASACAEAAMMACDATKRKSI
IVSKTVNPETRKVLKTYMHFKEVEVVEIEDADGVTDIEKLKEVIGPNTAAVIVQYPNFFGIIENLQEIEKITHEQKAMLI
TYVHPIPLGILKSPGEIGADIAVGDGQSLGNGLHYGGPYLGFLATTQKLLRRMPGRIVGQTKDVDGKRGFVLTLQAREQH
IRREKATSNICSNHSLNALTAAVYLATIGKKGIKEVAYQCLQKAHYAYTVLTESGKYKPAFNKPFFMEFALKTDKDVAEI
NKKLLEEGILGGYDLQRDYEKYKNVMLLAFTEKRTKEEIDRLKSLLEVM

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=414, Percent_Identity=35.024154589372, Blast_Score=252, Evalue=4e-67,
Organism=Escherichia coli, GI1789269, Length=402, Percent_Identity=32.5870646766169, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17535605, Length=402, Percent_Identity=36.318407960199, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323843, Length=453, Percent_Identity=32.2295805739514, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24645648, Length=414, Percent_Identity=36.9565217391304, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_THETN (Q8RCW1)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621986.1
- ProteinModelPortal:   Q8RCW1
- SMR:   Q8RCW1
- GeneID:   997934
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0294
- NMPDR:   fig|273068.3.peg.44
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   TTEN273068:TTE0294-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 50422; Mature: 50422

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVMFPYLPISSEDEKEMLKTIGKNSIEELFEVIPKEVRLNRPLNLGKPMSELEVRKRLG
CEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHC
SYADENKNLSQLVSFLGAGVYDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEY
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCHHHHHHHHHH
QTMITNLTGMEVTNASMYDGASACAEAAMMACDATKRKSIIVSKTVNPETRKVLKTYMHF
HHHHHCCCCCEECCCHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHH
KEVEVVEIEDADGVTDIEKLKEVIGPNTAAVIVQYPNFFGIIENLQEIEKITHEQKAMLI
HCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEE
TYVHPIPLGILKSPGEIGADIAVGDGQSLGNGLHYGGPYLGFLATTQKLLRRMPGRIVGQ
EEECCCCHHHCCCCCCCCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECC
TKDVDGKRGFVLTLQAREQHIRREKATSNICSNHSLNALTAAVYLATIGKKGIKEVAYQC
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQKAHYAYTVLTESGKYKPAFNKPFFMEFALKTDKDVAEINKKLLEEGILGGYDLQRDYE
HHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KYKNVMLLAFTEKRTKEEIDRLKSLLEVM
HHCCEEEEEECCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIVMFPYLPISSEDEKEMLKTIGKNSIEELFEVIPKEVRLNRPLNLGKPMSELEVRKRLG
CEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHC
SYADENKNLSQLVSFLGAGVYDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEY
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCHHHHHHHHHH
QTMITNLTGMEVTNASMYDGASACAEAAMMACDATKRKSIIVSKTVNPETRKVLKTYMHF
HHHHHCCCCCEECCCHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHH
KEVEVVEIEDADGVTDIEKLKEVIGPNTAAVIVQYPNFFGIIENLQEIEKITHEQKAMLI
HCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEE
TYVHPIPLGILKSPGEIGADIAVGDGQSLGNGLHYGGPYLGFLATTQKLLRRMPGRIVGQ
EEECCCCHHHCCCCCCCCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECC
TKDVDGKRGFVLTLQAREQHIRREKATSNICSNHSLNALTAAVYLATIGKKGIKEVAYQC
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQKAHYAYTVLTESGKYKPAFNKPFFMEFALKTDKDVAEINKKLLEEGILGGYDLQRDYE
HHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KYKNVMLLAFTEKRTKEEIDRLKSLLEVM
HHCCEEEEEECCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336